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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

ACS Applied Materials & Interfaces

A Chloroplast-Inspired Theranostic Nanoplatform for Self-Sustaining Oxygen-Elevating Photodynamic Therapy and Glutathione-Triggered Carbon-Centered Radical Synergistic Therapy

Jitong Gong, Yu Liu, Qingkun Yang, Ruohao Zhang, Yukai Cheng, Jing Feng, Hongjie Zhang

Abstract Achieving precise drug delivery to the tumor site can minimize systemic side effects caused by off-target effects. As a therapy that depends on oxygen content, photodynamic therapy (PDT) is significantly constrained by the hypoxic nature of the tumor microenvironment (TME). Compared with the limited efficacy of single PDT, the combination of multiple treatment modalities can achieve synergistic enhancement and superior therapeutic outcomes. Since carbon radical therapy does not rely on oxygen as a reactive …

21.08.2026journal-article

Multidiscipline Modeling in Materials and Structures

Integrated optimization of machining accuracy and occupational exposure in ECDM of CFRP composite

Manpreet Singh, Kumel K. Nagori, Jasgurpreet Singh Chohan, V. Sandeep, Pardeep Singh Bains, Ripendeep Singh, Lamia Abu El Maati, Mohd Ijaz

Purpose The electrochemical discharge machining (ECDM) is extensively employed for micro-machining of non-conductive and composite materials; however, the generation of hazardous fumes during the process raises concerns regarding machining environment and operator safety. This study aims to investigate machining quality and fume exposure during ECDM of carbon fiber reinforced polymer composites. Design/methodology/approach Experiments were designed using a central composite design with process parameters varied wit …

21.08.2026journal-article

Journal of Marital and Family Therapy

Portraying Mixed‐Agenda Couples: Insights From Large‐Scale Data Sets

Yike Tang, Shayne R. Anderson, Lee N. Johnson, Steven M. Harris, Anita Kateregga

ABSTRACT This study investigates “mixed‐agenda” couples characterized by significant discrepancies in commitment and therapy goals, using both clinical and non‐clinical data sets. While theoretical frameworks suggest these couples present unique challenges for treatment planning and therapy outcomes, empirical data on their prevalence have remained limited. We analyzed data from the National Couples' Health and Time Study (NCHAT) and the Marriage and Family Therapy Practice Research Network (MFT‐PRN) to identify gr …

21.08.2026journal-article

BMC Neurology

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Tristan Kölsche, Ramona Hagler, Niklas Huntemann, Lars Masanneck, Marc Müller, Bela Jesaja Kutsojannis, Joshua M. Boeckers, Patricia Kirschner, Karin Schulze-Bosse, Orhan Aktas, Sven G. Meuth, Tobias Ruck, Marc Pawlitzki

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 levels have been hypothesized to predict disease activity and long-term outcomes in multiple sclerosis (MS). However, the prognostic value of serum IL-6 in OCR-treated patients remains unclear. Therefore, the objective of this study was to evalu …

21.08.2026journal-article

Hemşirelik Bilimi Dergisi

Su Jok Therapy: A Bibliometric Analysis

Derya Şimşekli, Candan Doğan, Hatice Yağcı Karamanlı

Objective: This study was carried out using a bibliometric analysis method to examine the position and development process of Su Jok Therapy in the scientific literature, addressing the current lack of bibliometric studies in this field and guiding future clinical and experimental research.Methods: The analysis was conducted by examining 25 studies searched with the keyword ‘su jok’ in the Scopus database using the VOSviewer programme. Results: According to the results obtained, the majority of studies on Su Jok Th …

21.08.2026journal-article

Bioengineering

Functional Vascularization in Tumor Organoid and Tumor-on-Chip Models: Evidence Requirements for Attributing Therapy-Resistance Mechanisms

Yafang Li, Yiyi Yang, Lina Zhao, Zihao Bian, Zongjiu Zhang

Vascularized tumor organoid and tumor-on-chip models are increasingly used to examine treatment response, yet a weak therapeutic effect does not by itself identify the failed transport or biological step. Reduced efficacy may result from inadequate delivery, altered endothelial transport or signaling, stromal protection, impaired immune access or function, tumor-intrinsic resistance, or several processes acting together. A structured literature search and narrative synthesis were combined with a focused qualitative …

21.08.2026journal-article

Precision Radiation Oncology

Effects of proton therapy on the tumor immune system and clinical implications: A review

Rundong Liu, Mei Tao, Min Fu, Yingjia Hu, Zhen Tao, Guangyuan Hu

Abstract Proton therapy, an emerging radiation therapy technique, has gained significant attention owing to its unique physical properties and biological effects. This review aims to explore the impact of proton therapy on the tumor immune system and of its combination with other therapies. This review outlines the fundamental principles and oncological applications of proton therapy, followed by an analysis of its impact on the immune system—encompassing draining lymph nodes, peripheral blood immune cells, tumor c …

21.08.2026journal-article

Quarterly Journal of Experimental Psychology

EXPRESS: Occupational Stereotyping – Individual Differences in Susceptibility and in Response to Training

Eimear Finnegan, Alan Garnham, Jane Oakhill

In previous studies (Finnegan, 2014; Finnegan et al., 2015a, 2015b, 2023) we investigated effects of training on the reduction of occupational stereotypes indicated by responses to the question of whether two words (e.g., uncle/builder or aunt/builder) could refer to the same person. In each study we also collected individual difference measures of sexism, sexist language, sex typing and fear of negative evaluation. Considering the individual studies, the relations between the individual difference measures and mea …

21.08.2026journal-article

Children

From FGFR3 Hyperactivation to Disease-Modifying Therapy in Pediatric Achondroplasia: Molecular Mechanisms, Clinical Evidence, and Emerging Treatments

Rebecca Cristiana Șerban, Andreea Mitut-Veliscu, Alexandra Dumitra, Liana Marica, Cristina Popescu, Andrei Costache, Șerban Teona, Anca-Lelia Riza, Rodica Dirnu, Renata-Maria Varut, Ioana Streață

Background/Objectives: Achondroplasia is the most common genetic skeletal dysplasia associated with disproportionate short stature and is primarily caused by gain-of-function variants in the fibroblast growth factor receptor 3 (FGFR3) gene. Constitutive FGFR3 activation disrupts growth plate homeostasis and endochondral ossification through complex alterations in chondrocyte proliferation, differentiation, hypertrophy, extracellular matrix organization, and intracellular signaling. The increasing understanding of t …

21.08.2026journal-article

The Cerebellum

Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours

Rida Ahmed, Natalie Boll-Avetisyan, Jonathan Kjaer Grønbaek, Ditte Boeg Thomsen, Annet Kingma, Karin Persson, René Mathiasen, Christine Dahl, Andrea Carai, Bianca Andreozzi, Angela Mastronuzzi, Barry Pizer, Colin Thorbinson, Kristian Aquilina, Eelco Hoving, Marianne Juhler, Roel Jonkers, Vânia de Aguiar

Abstract Preoperative speech deficits in children with posterior fossa tumours (PFTs) may be linked to postoperative speech impairment (POSI), a hallmark of posterior fossa syndrome, yet this relationship remains underexplored. POSI is characterized by mutism or markedly reduced speech that resolves within weeks to months but often leaves persistent motor-speech deficits. Most existing literature has focused on postoperative outcomes, with limited attention to preoperative speech function. We therefore systematical …

21.08.2026journal-article

Scientia Generalis

ATUAÇÃO DA FISIOTERAPIA NAS DESORDENS DO EQUILÍBRIO NA ESCLEROSE MÚLTIPLA: Uma revisão sistemática

Denise Marins Barbosa, Fernando Leonardo Diniz Souza, Eduardo Paul Chacur, Wemerson Pereira dos Santos, Raphael Cezar Carvalho Maritns, Fredston Gonçalves Coimbra

A esclerose múltipla (EM) é uma doença crônica e inflamatória do Sistema Nervoso Central, que atinge a substância branca provocando lesões e destruição da mielina, oligodendrócitos e axônios. A EM representa grande impacto na qualidade de vida de uma pessoa, sendo relevante o seu conhecimento, comprometimento e abordagens fisioterapêuticas. Objetivo: Analisar e descrever as intervenções fisioterapêuticas nas desordens do equilíbrio de pacientes com EM. Metodologia: Trata-se de uma revisão sistemática da literatura, …

21.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Non-surgical periodontal therapy and systemic inflammatory biomarkers in patients with periodontitis and carotid plaque burden: a pilot study

Ana Maria Hofer, Andrei Picos, Alexandra Dădârlat-Pop, Raluca Tomoaia, Horia Rosianu, Ilyés Tamás, Monica Popa

Introduction Systemic inflammation is a key contributor to the pathophysiology of carotid plaque burden (CpB). Increasing evidence supports a link between periodontitis and systemic conditions, including endothelial dysfunction, and CpB. This study aimed to explore inflammatory mediators involved in cardiovascular disease that may represent shared mechanistic pathways between periodontitis and carotid plaque burden, and to determine whether non-surgical periodontal therapy modulates systemic inflammatory activity. …

21.08.2026journal-article

European Journal of Ophthalmology

Gene therapy clinical trials for inherited eye diseases: The pediatric perspective

Athanasia Sandali, Anna Nikolaidou, Theodora Gianni, Zacharenia Tsoukala, Ioannis Tsinopoulos, Lampros Lamprogiannis

Gene therapy is an increasingly useful treatment option, especially in children, where most inherited diseases manifest. This review provides a literature synthesis of current gene therapy treatments in pediatric ophthalmology. Our search encompassed the ClinicalTrials.gov database. Sixteen clinical trials with published results reporting gene therapy for genetic ocular diseases in children (under 18 years) were included. Diseases under investigation for gene therapy in children included Leber's Congenital Amaurosi …

21.08.2026journal-article

Journal of Occupational Medicine and Toxicology

Heart rate variability as a strain parameter in maritime settings: a scoping review of methodological approaches to data collection and analysis in field studies on the high seas

Daniel Vasylenko, Lorenz Scheit, Chiara Reck, Dorothee Dengler, Volker Harth, Marcus Oldenburg

Abstract Background Seafarers are exposed to unique occupational stressors that place sustained demands on the autonomic nervous system. Heart rate variability (HRV) represents a promising non-invasive tool for assessing mental and physical strain in maritime settings. However, its methodological application in real field conditions remains poorly characterized, and existing HRV guidelines do not specifically address the methodological challenges of maritime field studies. Methods A scoping review was conducted fol …

21.08.2026journal-article

Philology. Theory & Practice

The “video game chat” speech hypergenre from a communicative perspective (based on data from the Russian-language chat of the video game Dota 2)

Leonid Aleksandrovich Sushkov

This article focuses on describing the structure of the “video game chat” hypergenre, drawing on data from the Russian-language chat of the video game Dota 2. The study examines the specifics of this communicative phenomenon at the intersection of natural written discourse and computer-mediated communication. The objective of this research is to substantiate a three-level hierarchical model of the “video game chat” hypergenre, which integrates genres with distinct text generation mechanisms based on the holistic so …

21.08.2026journal-article

Inflammatory Bowel Diseases

Clinical and endoscopic features of checkpoint inhibitor–induced colitis and their association with selective immunosuppressive therapy use

Myrthe R Naber, Mick J M van Eijs, Jildou S Huitema, Jacco J de Haan, Karijn P M Suijkerbuijk, Marijn C Visschedijk, Fiona D M van Schaik

Abstract Background and Aims Immune checkpoint–inhibitor (ICI) colitis is a common adverse event that is primarily treated with corticosteroids but may require selective immunosuppressive therapy (SIT). Although endoscopic features have been associated with SIT use, it remains unclear whether these associations differ by ICI type. Methods We conducted a 2-center retrospective cohort study and included patients with histologically confirmed ICI colitis. Endoscopic images were reviewed by gastroenterologists speciali …

21.08.2026journal-article

Scholarly Journal of Science and Technology Research and Development

Evaluation of Thermal Comfort Strategies in Rehabilitation and Wellness Centres

Atunbi Olusola Adeola, Abdulrazaq Kunle Ayinla

Thermal comfort is a critical component of rehabilitation and wellness-centre design because physically active users generate substantial metabolic heat and may be vulnerable to heat stress. This study evaluated thermal comfort strategies in selected rehabilitation, wellness, and gymnasium facilities in Ibadan, Nigeria, with the aim of informing the design of the Adewole Rasheed Ladoja Gymnasium. A mixed-method approach combined questionnaire survey, field observation, architectural documentation and case-study ass …

21.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Goal Setting During Telerehabilitation in Japan: Qualitative Study of Occupational Therapists’ and Physical Therapists’ Experiences Using Reflexive Thematic Analysis

Yuho Okita, Kounosuke Tomori, Minoru Okita

Abstract Background Telerehabilitation expanded rapidly during the COVID-19 pandemic and is increasingly used alongside, or as an alternative to, in-person rehabilitation. Goal setting is a core component of client-centered rehabilitation; however, how therapists conduct goal setting remotely remains poorly understood, particularly in East Asian contexts. To our knowledge, no qualitative study has specifically examined remote goal setting in telerehabilitation in Japan, where remote delivery was not yet routine whe …

21.08.2026journal-article

Medicine

Very early versus early exercise rehabilitation after intracerebral hemorrhage

Taiqiang Kan, Lining Ding, Siqi Wang, Tong Li, Yunfei Li, Zhongqin He, Chun Shi, Chenbang Ma, Zhuang Li, Bensi Zhang

Background: The optimal timing of rehabilitation initiation after intracerebral hemorrhage (ICH) remains uncertain. This systematic review and meta-analysis compared the efficacy and safety of very early versus early exercise rehabilitation after ICH. Methods: Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Science and Technology Journal Database/VIP Database, Wanfang, PubMed, Embase, the Cochrane Library, Web of Science, ClinicalTrials.gov, and the Chinese Clinical Trial Re …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Occupational disease risks in natural resource-based industries among a large cohort of workers in Ontario, Canada

Taryn Thompson, Katie Goggins, Paul A Demers, Katherine J Jardine, Meg Parker, Jeavana Sritharan

Background Natural resource-based industries are critical to many economies. Although workers in these industries face several hazardous exposures, the industry-specific risks of occupational diseases remain underexplored. Objective This study aimed to identify high-risk occupational diseases among workers in Ontario's natural resource-based industries. Methods Workers were identified in the Occupational Disease Surveillance System (ODSS), a system linking workers’ compensation data (1983–2019) to health records. C …

21.08.2026journal-article

Healthcare

Comparison and Agreement of Criteria for Classifying Improvement in Walking Ability During Inpatient Rehabilitation After Spinal Cord Injury

Urška Puh, Tea Čuk, Bojan Čeru, Gaj Vidmar

Background/Objectives: To evaluate classification of improvement and agreement of walking-ability improvement criteria derived from outcome measures of walking capacity and performance among inpatients with spinal cord injury (SCI). Methods: Retrospective analysis of admission and discharge data from adults with SCI in the single-centre database from years 2020 to 2023: Six-minute Walk Test (6MWT), Ten-metre Walk Test (10MWT), Walking Index for Spinal Cord Injury; selected items of Spinal Cord Independence Measure …

21.08.2026journal-article

The Oncologist

IUC26661-86 Real-world outcomes in patients with Metastatic Hormone-Sensitive Prostate Cancer treated with androgen deprivation therapy and Apalutamide - A single centre study

K Marchon, S Brown, K Swaminathan, S Adeyemi, G Kapur

Abstract Background Apalutamide, in combination with androgen deprivation therapy (ADT), is used to treat patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, real-world evidence describing its effectiveness and tolerability remains limited. This study aimed to assess outcomes in mHSPC patients treated with apalutamide at a single centre. The primary objective was to evaluate treatment-related adverse events. Secondary objectives include overall survival, prostate-specific antigen (PSA) and …

21.08.2026journal-article

Aesthetic Plastic Surgery

Pilot Study of Combined Tranexamic Acid Therapy in Breast Reduction – Intravenous and Local Infiltration

Margarida Silva, Pedro Machado, António Sousa Barros, António Costa-Ferreira

Abstract Background Tranexamic acid (TXA) reduces perioperative blood loss in several surgical fields; however, its role in breast reduction surgery remains unclear. This study aimed to evaluate the effect of combined TXA therapy (intravenous and local infiltration) on postoperative outcomes of patients who underwent modified Liacyr Ribeiro breast reduction. Methods We conducted a controlled, non-randomized pilot study of patients who underwent bilateral reduction mammoplasty by the same surgeon. The intervention g …

21.08.2026journal-article

Nature Communications

CD11b agonist GB1275 potentiates oncolytic bacterial therapy against pancreatic cancer in mouse tumor models

Bin Zhang, Meng Guan, Xiao-Ting Xie, Jia-Hua Zou, Kai Cheng, Yuan-Di Zhao, Bo Liu, Jin-Xuan Fan, Qiu-Ran Xu

Abstract Oncolytic bacteria are microorganisms with cytotoxic activity capable of lysing cancer cells while simultaneously activating both innate and adaptive immune responses to exert anti-tumor effects. However, the innate immune activation targeting oncolytic bacteria within the tumor microenvironment (TME) is a limiting factor. Here we find that the CD11b-targeting agonist GB1275 can modulate bacteria-immune interaction and inhibit the infiltration of CD11b⁺ innate immune cells such as neutrophils and macrophag …