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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

International Journal For Multidisciplinary Research

Occupational De Quervain’s Tenosynovitis in a Physiotherapy Intern: A Case Report of Repetitive Manual Therapy and Ergonomic Modification

Lav Sarle

Abstract Background De Quervain’s tenosynovitis (DQT) is an overuse condition affecting the abductor pollicis longus (APL) and extensor pollicis brevis (EPB) tendons in the first dorsal compartment of the wrist. De Quervain’s tenosynovitis is commonly caused by repeated thumb and wrist movements. Physiotherapists performing soft tissue manual therapy such as myofascial release (MFR) and ultrasound treatment are at risk of developing this work-related musculoskeletal disorder. Objective To report a case of occupatio …

21.08.2026journal-article

Medicine

Prognostic factors and outcomes associated with postmastectomy radiation therapy following neoadjuvant chemotherapy and mastectomy for breast cancer

Hye Jin Kang, Myungsoo Kim, Yoo-Kang Kwak, So Jung Lee

The indications for postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) remain controversial. We aimed to identify prognostic factors and investigate subgroups in which PMRT could improve treatment outcomes. This study included 178 patients with clinical stage II–III breast cancer who underwent mastectomy after NAC between May 2006 and December 2022. PMRT was administered to 149 (83.7%) patients. The median follow-up period was 64 months. The response to NAC, molecular subtype, and patholog …

21.08.2026journal-article

Indonesian Journal of Global Health Research

The Effect of Coloring Play Therapy on Anxiety Levels in Children During Hospitalization

Aisyah Nurul Fadhillah, Irdawati Irdawati

Hospitalization can be an anxiety-inducing experience for preschoolers due to the unfamiliar environment and frightening medical procedures. One intervention that can help reduce anxiety is coloring. This study aims to determine the effectiveness of coloring play therapy on children's anxiety levels during hospitalization. The method used is a case study, with a pediatric nursing care approach, applying Evidence-Based Nursing. The research subjects were taken using a purposive sampling method and the results obtain …

21.08.2026journal-article

Journal of Humanities and Social Sciences Research

The Effect of a Rehabilitation Program Accompanied by the Smart TECAR Device in Restoring Muscular Strength and Range of Motion after Complete Achilles Tendon Rupture Repair in Athletes

Ali Salim Khazal Al-Qurashi

The significance of this research lies in designing a rehabilitation program for surgical cases following Achilles tendon rupture in athletes, given the tendon's importance in movement and body support. The Achilles tendon is one of the major tendons that functions as a recoil spring against the ground reaction force generated by body weight, owing to its tensile elasticity. It therefore holds great importance for athletes, and the speed of returning to sport practice represents a challenge in terms of both speed a …

21.08.2026journal-article

Frontiers in Rehabilitation Sciences

A modified hybrid hub-spoke model for assistive technology: institutional design for procurement, financing, and market-shaping

Goran Radosavljević, Aleksandra Lazevski

Introduction Access to assistive technology (AT) is often constrained by fragmented governance structures, inconsistent procurement mechanisms, and unequal regional capacities, resulting in gaps in service quality and limited equity for users. To address these systemic barriers, this paper introduces a modified hybrid hub-spoke model developed as an integrated organizational solution for optimizing AT delivery. Methods The model is grounded in comparative insights from mature AT systems (Norway, Italy) and evolving …

21.08.2026journal-article

Frontiers in Oncology

Development of a nomogram for predicting axillary pathologic complete response after neoadjuvant therapy in clinically node-positive breast cancer

Bin Li, An Yi, Tenghua Yu, Yongqiang Bao, Lihong He, Zhuoyu He, Jin Liu, Yan Liu, Chunling Jiang

Background Reliable and accessible tools for estimating axillary pathologic complete response (ax-pCR) after neoadjuvant therapy (NAT) remain limited. This study evaluated whether routinely available biomarkers measured before and after NAT provide complementary information for ax-pCR prediction. Methods We conducted a retrospective study of patients with clinically node-positive, non-metastatic breast cancer who underwent NAT followed by surgery. Clinicopathological characteristics, treatment information, serum al …

21.08.2026journal-article

BMC Urology

Association of metformin use with metabolic trajectories and disease progression in prostate cancer patients receiving androgen deprivation therapy: a target trial emulation study

Yongkai He, Liang Tang, Kun Yuan, HuiYing Liu, ZhiWei Huang, Zhen Liu, Yu Liu, Quan Yang, Bo Chen

Abstract Background Androgen deprivation therapy (ADT) is associated with substantial metabolic deterioration in patients with prostate cancer. Metformin may attenuate ADT-related metabolic complications, although its association with longitudinal metabolic trajectories and prostate cancer outcomes remains uncertain. Methods We conducted a retrospective cohort study emulating a target trial using a 90-day landmark design. Patients with prostate adenocarcinoma initiating ADT between 2015 and 2020 were classified acc …

21.08.2026journal-article

The Oncologist

IUC26678-94 Impact of Metastatic Patterns on First-Line Therapy in mRCC: Meet-URO 33

E Peretto, S E Rebuzzi, E Verzoni, S Buti, M Di Napoli, C Lolli, M Fanelli, C Masini, P A Zucali, A Mennitto, M Sorarù, R Filippi, L Formisano, C Messina, F Maines, G Fornarini, S Chiellino, L Bonomi, D Bimbatti

Abstract Background Metastatic site is a well-recognized prognostic factor in metastatic renal cell carcinoma (mRCC). Endocrine metastases, particularly to the pancreas and thyroid, are associated with favorable outcomes, whereas bone, liver, and brain metastases are linked to poorer prognosis. However, whether these metastatic patterns influence first-line treatment selection remains unclear. Methods Meet-URO 33 is an ongoing Italian multicenter retrospective/prospective observational study including patients with …

21.08.2026journal-article

The Oncologist

IUC26666-91 Prediction of immune-related adverse events (irAEs) with hematologic markers in patients receiving first-line immune checkpoint inhibitor (ICI)-based therapy in metastatic renal cell carcinoma (mRCC)

R Winayak, X Li, N J Salgia, K Makins, V A De Goes, A Moradi, J Hsu, H Ebrahimi, A Chehrazi-Raffle, S K Pal

Abstract Background First-line therapies with combinations of ICI-ICI and ICI-tyrosine kinase inhibitor (TKI) are commonplace in mRCC. The frequency of irAEs in patients receiving first-line ICI-based therapies is high, with grade ≥ 2 (G ≥ 2) typically warranting active management. Although prognostication based on irAEs has been demonstrated, the prediction of irAE occurrence in mRCC remains a challenge. We investigated the role of baseline hematologic markers to predict G ≥ 2 irAE occurrence with first-line ICI-b …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Occupational health and safety management system, robotics, and the adjustment of labor structure

Jingjing Yang, Weiming Liang

Background Achieving a productive coexistence between robotics and human labor without compromising operational efficiency is a key challenge for enterprises. While various solutions have been suggested, Occupational health and safety management systems (OHSMS) is frequently overlooked. Objective This study investigates the impact of OHSMS on the application of industrial robots in manufacturing firms, with a particular focus on its role in balancing automation transformation and employment stability. Methods A two …

21.08.2026journal-article

Obstetric Anesthesia Digest

Treatment of Traumatic Birth Experience With Postpartum Early Eye Movement Desensitization and Reprocessing Therapy: A Randomized Clinical Trial

YMGA Hendrix, MG van Pampus, A Hofman, J Henrichs, HE van der Horst, A de Jongh

( Am J Obstet Gynecol 2025;233:654.e1–25. doi: 10.1016/j.ajog.2025.07.051) Studies show that around 10% to 20% of women view childbirth as a traumatic experience. This can happen in both medically complicated and uncomplicated deliveries and can have vast negative effects for both mother and infant. These potential effects include post-traumatic stress disorder (PTSD), troubles with mother-infant bonding, postpartum depression, childbirth fears, or lower quality of life.

21.08.2026journal-article

Frontiers in Environmental Health

Online news monitoring as a complementary sentinel tool for occupational heat-related adverse events: a six-year descriptive study in Italy (2020–2025)

Giulia Ionita, Erica Mencucci, Giulia Guerri, Alisa Barash, Letizia Fattorini, Mario Bruschi, Claudia Cosma, Alice Fanfani, Simona Verdi, Donatella Talini, Michela Bonafede, Alessandro Marinaccio, Marco Morabito, Miriam Levi

Introduction Climate change is increasing the frequency and intensity of heatwaves, with significant impacts on occupational health. Work-related heat illnesses and injuries are often underestimated by traditional surveillance systems. This study aimed to assess the use of national and local daily newspapers as a sentinel surveillance tool for monitoring occupational adverse events associated with heat stress in Italy. Methods Online news articles published between May and September from 2020 to 2025 were analyzed …

21.08.2026journal-article

Applied Sciences

Speech Signal Preprocessing and Feature Extraction for Biomarker Identification in Acute Heart Failure: A Pilot Study

Andrzej Majkowski, Tomasz Rywik, Paweł Irzmański, Jakub Czapnik, Marcin Kołodziej, Anna Drohomirecka

This study presents a configurable speech signal preprocessing and feature-extraction workflow for identifying candidate acoustic biomarkers in acute heart failure. The workflow was evaluated in 12 patients hospitalized with acute heart failure. Short recordings of repeated vowels /a/, /i/, and /o/ were acquired shortly after admission and again before discharge following treatment and clinical stabilization. The pipeline included active-RMS normalization, automatic segmentation of repeated vowels, optional edge tr …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Ergonomic and self-care strategies for musculoskeletal health in the work-from-home era: Trends in public interest across COVID-19

Howard S. Lao, Scott Telfer

Background The COVID-19 pandemic accelerated home and hybrid work, often without time to establish ergonomic workstations. Objective This study examined whether U.S. public interest in ergonomic products and self-care strategies increased during the pandemic and whether elevated interest persisted afterward. Methods Monthly U.S. Google Trends relative search volume (RSV) was analyzed for 23 ergonomics and recovery terms from March 2018 to March 2025. Periods were defined as pre-COVID (March 2018–February 2020), dur …

21.08.2026journal-article

NeuroSci

Responsive Neurostimulation Therapy Outcomes in Two Small Bilateral Thalamic and Corticothalamic Subgroups of Patients with Drug-Resistant Epilepsy—A Single-Center Experience

Ramya Krothapally, Ghazala Perven, Divya Veerapaneni, Irina Podkorytova

Responsive neurostimulation (RNS) is a neuromodulation option for treatment of drug-resistant epilepsy (DRE). There is limited data reviewing bilateral thalamic and corticothalamic RNS therapy response. We performed a retrospective analysis of 21 patients undergoing RNS implantation with either bilateral thalamic (n = 17) or corticothalamic (n = 4) leads and ≥6 months of follow-up. Patients were classified as responders (≥50% seizure frequency reduction) vs. non-responders (

21.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Octreotide as Adjunctive Therapy for Catecholamine-Secreting Pheochromocytoma and Paraganglioma

Omayma Elshafie, Abir Bou Khalil, Bushra H Salman, Boris L Itkin, Nicholas Woodhouse, Ali S Alzahrani

Abstract Context Catecholamine-secreting pheochromocytomas and paragangliomas (PPGLs) can be difficult to stabilize before surgery or during follow-up. Somatostatin receptor expression provides a rationale for octreotide therapy, but clinical evidence is limited. Objective To evaluate biochemical, clinical, hemodynamic, metabolic, and perioperative outcomes associated with octreotide treatment in catecholamine-secreting PPGLs. Methods We retrospectively studied 27 consecutive patients with PPGLs treated with octreo …

21.08.2026journal-article

The Indonesian Journal of Occupational Safety and Health

Assessing Safety Culture Maturity at PT ABC Heavy Equipment Manufacturing

Rogo Sukmo, Indriati Paskarini, Nabilah Nur Hasanah

Introduction: Heavy equipment manufacturing is a high-risk industry that requires effective hazard management and a strong safety culture to prevent workplace accidents. This study explores the maturity level of safety culture in a heavy equipment manufacturing industry in Bekasi, Indonesia, using Fleming's five-stage safety culture maturity model, and identifies the correlation between safety culture maturity and five aspects of organizational factors. Methods: This study used a quantitative cross-sectional design …

21.08.2026journal-article

Annals of Medicine & Surgery

Radiofrequency ablation combined with systemic therapy versus systemic therapy alone for unresectable colorectal liver metastases: a systematic review and meta-analysis

Danyal Bakht, Maleeha Tahir, Fahad Saleem, Maaz Amir, Abdullah Shahid Farooq, Zarwa Rashid, Faiza Yousaf, Minahil Rasul, Mustabeen Zahra Naqvi, Iqra Shahid, Noor Ul Sabah, Muhammad Numan Awais, Muhammad Waleed, Sarah Aijaz

Background: Colorectal cancer liver metastases (CRLM) remain a major therapeutic challenge with limited curative options. Radiofrequency ablation (RFA) has emerged as a potential adjunct to systemic therapy, but its survival benefit remains uncertain. Methods: This systematic review and meta-analysis was conducted according to PRISMA guidelines. PubMed, the Cochrane Library, ScienceDirect, and Embase were searched through 16 June 2025. Data were analyzed using RevMan version 5.4. Hazard ratios (HRs) were pooled for …

21.08.2026journal-article

Experimental Oncology

DYNAMIC ANDROGEN RESPONSE INDEX AND ITS ASSOCIATION WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY FOLLOWING NEOADJUVANT ANDROGEN DEPRIVATION THERAPY

Ye. Afanasiev, S. Vozianov, R. Danylets, V. Grygorenko, O. Shulyak, M. Sosnin, I. Kholokharenko

Background. Neoadjuvant androgen deprivation therapy (NADT) before radical prostatectomy (RP) remains controversial in the management of localized and locally advanced prostate cancer. A major limitation of this strategy is the lack of biomarkers capable of identifying tumors biologically sensitive to androgen deprivation. This study aimed to evaluate the prognostic value of a dynamic androgen response index (IAR) and develop a predictive model for biochemical recurrence (BCR) after RP. Materials and Methods. The r …

21.08.2026journal-article

Revista de Pesquisa Cuidado é Fundamental Online

Factors associated with and coping strategies for occupational stress among workers in a psychiatric hospital / Fatores percebidose estratégias de enfrentamento do estresse ocupacional entre trabalhadores de um hospital psiquiátrico

Olga Maria Castro de Sousa, Jefferson Abraão Caetano Lira, Nanielle Silva Barbosa, Amanda Alves de Alencar Ribeiro, Ítalo Arão Pereira Ribeiro, Sandra Cristina Pillon, Márcia Astrês Fernandes

Objetivo: analisar as percepções de trabalhadores de um hospital psiquiátrico acerca dos fatores associados e das estratégias de enfrentamento do estresse ocupacional. Método: estudo qualitativo, exploratório-descritivo, realizado em hospital psiquiátrico público no Piauí, Brasil, com 33 trabalhadores de diferentes categorias profissionais. A coleta ocorreu por meio da plataforma Mentimeter®, após atividade educativa sobre Síndrome de Burnout. Os dados foram submetidos à Análise de Conteúdo de Bardin. Resultados: e …

21.08.2026journal-article

ACS Applied Materials & Interfaces

A Chloroplast-Inspired Theranostic Nanoplatform for Self-Sustaining Oxygen-Elevating Photodynamic Therapy and Glutathione-Triggered Carbon-Centered Radical Synergistic Therapy

Jitong Gong, Yu Liu, Qingkun Yang, Ruohao Zhang, Yukai Cheng, Jing Feng, Hongjie Zhang

Abstract Achieving precise drug delivery to the tumor site can minimize systemic side effects caused by off-target effects. As a therapy that depends on oxygen content, photodynamic therapy (PDT) is significantly constrained by the hypoxic nature of the tumor microenvironment (TME). Compared with the limited efficacy of single PDT, the combination of multiple treatment modalities can achieve synergistic enhancement and superior therapeutic outcomes. Since carbon radical therapy does not rely on oxygen as a reactive …

21.08.2026journal-article

Multidiscipline Modeling in Materials and Structures

Integrated optimization of machining accuracy and occupational exposure in ECDM of CFRP composite

Manpreet Singh, Kumel K. Nagori, Jasgurpreet Singh Chohan, V. Sandeep, Pardeep Singh Bains, Ripendeep Singh, Lamia Abu El Maati, Mohd Ijaz

Purpose The electrochemical discharge machining (ECDM) is extensively employed for micro-machining of non-conductive and composite materials; however, the generation of hazardous fumes during the process raises concerns regarding machining environment and operator safety. This study aims to investigate machining quality and fume exposure during ECDM of carbon fiber reinforced polymer composites. Design/methodology/approach Experiments were designed using a central composite design with process parameters varied wit …

21.08.2026journal-article

Journal of Marital and Family Therapy

Portraying Mixed‐Agenda Couples: Insights From Large‐Scale Data Sets

Yike Tang, Shayne R. Anderson, Lee N. Johnson, Steven M. Harris, Anita Kateregga

ABSTRACT This study investigates “mixed‐agenda” couples characterized by significant discrepancies in commitment and therapy goals, using both clinical and non‐clinical data sets. While theoretical frameworks suggest these couples present unique challenges for treatment planning and therapy outcomes, empirical data on their prevalence have remained limited. We analyzed data from the National Couples' Health and Time Study (NCHAT) and the Marriage and Family Therapy Practice Research Network (MFT‐PRN) to identify gr …

21.08.2026journal-article

BMC Neurology

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Tristan Kölsche, Ramona Hagler, Niklas Huntemann, Lars Masanneck, Marc Müller, Bela Jesaja Kutsojannis, Joshua M. Boeckers, Patricia Kirschner, Karin Schulze-Bosse, Orhan Aktas, Sven G. Meuth, Tobias Ruck, Marc Pawlitzki

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 levels have been hypothesized to predict disease activity and long-term outcomes in multiple sclerosis (MS). However, the prognostic value of serum IL-6 in OCR-treated patients remains unclear. Therefore, the objective of this study was to evalu …