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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Endovascular Therapy

Endovascular Aspiration Thrombectomy of the Superior Mesenteric Artery for Treatment of Acute Mesenteric Ischemia: Results From the ENDO-SMA2MI Registry

Mario D’Oria, Sandro Lepidi, Paolo Spath, Mauro Gargiulo, Ciro Ferrer, Gioele Simonte, Stefano Gennai, Francesco Giurazza, Anna Maria Ierardi, Diego Visconti, Reinhold Perkmann, Raffaello Bellosta, Nicolò De Manzini, Cristiano Calvagna, Alan Biloslavo

Background/Objective. Acute mesenteric ischaemia (AMI) is a multidisciplinary emergency, requiring the involvement of different medical specialties for successful management. Endovascular aspiration thrombectomy (EAT) has entered the field leading to the possibility of treating acute arterial occlusions with a minimally invasive approach. The aim of the study was to provide contemporary data on results after use of EAT in AMI patients. Methods. The study was a retrospective, observational, multicentre study conduct …

28.08.2026journal-article

International Journal of Cancer

Estimation of Subtype‐Specific Tumour Growth Rate Distributions and Interval Cancer Proportions in Breast Cancer Using Biology‐Inspired Natural History Models

Letizia Orsini, Yuqi Zhang, Kamila Czene, Keith Humphreys

ABSTRACT Breast cancer progression varies across molecular subtypes, influencing detection rates and prognosis. Differences in the proportion of interval cancers (PIC)—cancers detected symptomatically between scheduled screening rounds—have been observed across subtypes, likely reflecting heterogeneity in tumour growth dynamics. We applied a continuous‐growth natural history model to a cohort of 7818 breast cancer patients diagnosed between 2007 and 2020 in Sweden. Using subtype‐specific estimates, we quantified th …

28.08.2026journal-article

Diagnostics

Stratified Analysis of Patients Within the PSA Gray Zone (4–10 ng/mL) and Its Clinical Application Value: Development of a Predictive Model for Clinically Significant Prostate Cancer Using Quantitative Indicators of PSA, ADC, and Relative T2 Value

Pan Hao, Tong Zhu, Ruiqiang Xin, Xiaoyong Lv

Objective: Patients with prostate-specific antigen (PSA) levels in the 4–10 ng/mL gray zone present a diagnostic challenge, as PSA alone cannot reliably distinguish clinically significant prostate cancer (csPCa) from benign conditions or indolent disease, potentially leading to unnecessary biopsies or missed clinically significant disease. This study aimed to develop a risk prediction model for csPCa in this population using clinical indicators and magnetic resonance imaging (MRI) quantitative data, and to evaluate …

28.08.2026journal-article

Medicina

Clinical and Dermoscopic Determinants of Surgical Decision-Making in Skin Cancer Screening: A Retrospective Analysis

Adrian Chwojnicki, Sebastian Makuch, Hanna Adamska, Michalina Świetlicka, Maja Hrynczyszyn, Inga Buława, Paulina Piesch, Jacek Polański, Wojciech Tański

Background and Objectives: Deciding which pigmented or non-pigmented skin lesions require surgical excision, as opposed to continued observation, is a common challenge in everyday dermatologic practice. Although dermoscopy is well established as a tool that improves melanoma detection accuracy compared with naked-eye examination, real-world evidence on how demographic profile, patient history, and dermoscopic impression jointly influence the surgical decision remains limited. This study examined the clinical and de …

28.08.2026journal-article

World Journal of Gastroenterology

Endoscopic follow-up in colorectal cancer: Comparisons and critical issues across different guidelines

Sara Cherri, Daniele Salvi, Edoardo Pezzuto, Elisa Tabbone, Alberto Zaniboni, Paola Cesaro

Endoscopic surveillance plays a fundamental role in the long-term management of patients treated for colorectal cancer. Despite significant advances in surgical techniques, systemic therapies, and molecular diagnostics, recurrence and metachronous neoplasia remain clinically relevant challenges, particularly within the first three years following curative-intent treatment. This review summarizes current evidence and major guideline recommendations on endoscopic follow-up after colorectal resection, endoscopic remov …

28.08.2026journal-article

Frontiers in Oncology

Clonal evolution in gastrointestinal cancers: multi-omics insights into tumor heterogeneity, microenvironmental selection, and translational biomarkers

Wenyi Fan, Chunhong Zheng

Clonal evolution in hepatocellular carcinoma (HCC), esophageal squamous cell carcinoma (ESCC), and gastric cancer (GC) reflects the interaction of genetic diversification, cell-state plasticity, and tissue-specific selection. Multi-region and single-cell DNA sequencing resolve truncal and subclonal lineages, whereas single-cell and spatial transcriptomics, proteomics, and serial liquid biopsy characterize cellular states, ecological niches, and temporal dynamics. The three cancers differ in dissemination timing, do …

28.08.2026journal-article

Arthritis & Rheumatology

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

Antonio Tonutti, Francesca Motta, Liala Moschetti, Cosimo Bruni, Carina Mihai, Claudia Iannone, Maria Rosa Pellico, Stefano Stano, Stefano Erba, Claudia Barison, Eleonora Pazzi, Andrea Benini, Beatrice Moccaldi, Kurszán Jász Dávid, Ágnes Ágoston‐Szabó, Beatrice Gabrielli, Francesca Nava, Dóra Tari, Francesca Romana Di Ciommo, Yuri Sasaki, Gonçalo Boleto, Radim Bečvář, Alejandro Brigante, Britta Maurer, Massimiliano Limonta, Rahma A. Elziaty, Fabiola Atzeni, Lilian Maria López Núñez, Roberta Foti, Francesco Benvenuti, Brigitte Granel, Elena Rezus, Leila Caillault, Sophie Blaise, Cristiana Sieiro Santos, Fabio Cacciapaglia, Roberto Giacomelli, Rossella De Angelis, Serena Guiducci, Duygu Temiz Karadag

Background Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti‐RNA polymerase III (POLR3)‐positive disease, needing further exploration. Methods We performed a nested case‐control study within EUSTAR: cases were SSc patients developing cancer at any timepoint; controls were cancer‐free SSc matched for age and disease duration. Malignancies were classified as synchronous to SSc onset (±3 years), subsequent …

28.08.2026journal-article

Frontiers in Oncology

Integrating intratumoral and peritumoral radiomics with deep transfer learning from multiparametric MRI for preoperative prediction of HER2 status in breast cancer: a multicenter study

Saisai Zhang, Jing Rong, Tiantian Liu, Xiujuan Yin, Shuqin Xue, Likang Yin, Lei Liu, Yang Ji, Xijun Gong, Xiao Wang

Purpose To develop and validate a combined model integrating intratumoral and peritumoral radiomics features, deep transfer learning features from multiparametric MRI (DCE-MRI, T2WI, and DWI), and clinical indicators, and to evaluate its diagnostic performance and clinical utility for preoperative prediction of HER2 expression status in breast cancer. Methods We collected data from 411 breast cancer patients from three centers retrospectively (training set: 212; internal validation set: 91; external test sets: 50 a …

28.08.2026journal-article

Angewandte Chemie International Edition

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim

ABSTRACT Light‐driven photoredox catalysis can shift intracellular NADH/NAD + balance by oxidizing NADH, but intracellular NADH pools are dynamically replenished through enzyme‐coupled redox metabolism. We show that ALDH‐mediated restoration of NADH/NAD + balance can buffer photoredox‐induced NADH depletion, providing a design rationale for coupling enzyme inhibition with photoredox catalysis. To counteract this redox‐buffering process, we introduce an enzymatic–photocatalytic strategy, termed E–PC, that integrates …

28.08.2026journal-article

ACS ES&T Engineering

Exogenous Folate Supplementation Weakens Cross-Feeding and Enriches Marine Anammox Bacteria in Marine Wastewater Treatment

Hui Lv, Weichuan Kong, Yuhui Fang, Xiaocui Wang, Jin Li

Abstract Cross-feeding, defined as the exchange of metabolites within the microbiome, plays a critical role in the promotion of bacterial activity and growth. Marine anammox bacteria (MAB) possess natural advantages for the treatment of marine wastewater (MW). Herein, the folate-mediated cross-feeding mechanism in MAB-based microbiome was first elucidated under salt stress. The total nitrogen removal rate notably reached 5.2 kg/(m3·d) at the optimal exogenous folate concentration (1.1 mg/L). The stoichiometric rati …

28.08.2026journal-article

Clinical Cancer Research

Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study

Jennifer Y. Sheng, Marianna L. Zahurak, Faith Too, Amanda Montanari, Jennifer Trost, Mengyang Lu, Young Lee, Sheetal Parida, Amanda L. Blackford, Dipali Sharma, Marci Laudenslager, Claire Snyder, Janelle W. Coughlin, Vered Stearns

Abstract Purpose: Behavioral weight loss (BWL) interventions consisting of remote coaching and self-monitoring have limited effectiveness in breast cancer survivors. We conducted a single-arm phase II study evaluating the addition of Contrave for <5% weight loss (%WL) after 2 months of BWL. Patients and Methods: Women with prior stage 0 to III breast cancer and a body mass index ≥27 kg/m2 were eligible and initiated BWL. We collected weight, patient-reported outcomes, and labs at baseline, 2 months, and 6 months. A …

28.08.2026journal-article

Journal of Mechanics in Medicine and Biology

ENHANCING RADIOTHERAPY SAFETY IN HEAD AND NECK CANCER TREATMENT: A HYBRID DOUBLE-LAYERED ORTHODONTIC MOUTH GUARD

YOJANA SHARMA, AYUSH AWASTHI, MOHIT PANT, PARNIKA SHRIVASTAVA

Radiotherapy is a widely used method in the treatment of head-and-neck cancers; however, irradiation of surrounding oral structures often results in clinical complications such as dental caries, oral mucositis, osteoradionecrosis, dysphagia, dysgeusia, xerostomia and trismus. To address such issues, a patient-specific hybrid double-layer orthodontic mouthguard has been proposed to simultaneously enhance the radiation shielding and biomechanical comfort in treatments. The customized device integrates radiation-shiel …

28.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Raman and surface-enhanced Raman spectroscopy for intraoperative cancer diagnostics: sentinel lymph node biopsy, biomarkers and translational challenges

Jiaqi Feng, Chunyan Li, Xiaowei Jiang, Lizhi Zhou, Yifei Jiang, Binge Deng

Sentinel lymph node biopsy (SLNB) serves as the gold standard for staging regional lymph node metastasis of solid tumors, which is crucial for guiding clinical treatment decisions and evaluating prognosis. Conventional intraoperative detection methods for SLN, such as frozen section and touch imprint cytology, have limitations including low sensitivity for micrometastasis, long detection time, and high subjectivity. Raman spectroscopy (RS), as a label-free, non-destructive optical molecular imaging technology, can …

28.08.2026journal-article

Breast Cancer Research

MDM2 inhibition restores p53 function to overcome dual endocrine and CDK4/6 inhibitor resistance in ER+ breast cancer

Leila Eshraghi, Fiona H. Zhou, Sarah Alexandrou, Chan Jae Lee, Chau Lam Miu, Aliza Yong, Ashleigh Wilkinson, Denise Attwater, Man Ting Siu, Kristine Fernandez, Heloisa H. Milioli, Andrew Parker, Davendra Segara, C. Elizabeth Caldon, Neil Portman, Elgene Lim

Abstract Background Approximately 70% of breast cancers are estrogen receptor (ER)-positive, with endocrine therapy (ET) forming the treatment backbone. ET plus CDK4/6 inhibitors is standard-of-care for advanced and high-risk early-stage ER+ breast cancer. Despite improved outcomes, resistance and progression remain major challenges. p53 is wild type in most ER+ cancers and is suppressed by its negative regulator MDM2. We previously showed that MDM2 inhibition is effective in ET-resistant ER+ models, however its ef …

28.08.2026journal-article

Oncology Reviews

Clinical value of combined SHOX2 and RASSF1A methylation in lung cancer diagnosis across tissue and liquid biopsy samples: a systematic review and meta-analysis

Ting Wang, Jianguo Zhang, Jiayang Wang, Xiaoqun Dong, Qiushi Lin, Leiming Guo, Bo Zhang, Yue Cao, Yining Zhai, Mathhew Hadfield, Khan Hina, Abbas E. Abbas, Hong Ge, Liang Cheng, Hang Xing, Yifei Liu

Lung cancer remains the leading cause of cancer-related mortality worldwide, with poor prognosis in advanced stage diseases. Although early diagnosis has the potential to improve patient outcomes, current diagnostic methods remain suboptimal, highlighting the need for accurate molecular biomarkers. We systematically reviewed 49 studies to evaluate the diagnostic performance of SHOX2 methylation, RASSF1A methylation, and their combined panel for lung cancer detection. The combined SHOX2/RASSF1A methylation panel dem …

28.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Enhanced Brain Tumor Classification Using Capsule Networks with Hybrid Activation Function

Mamta Sharma, Sunita Beniwal

Detection of life-threatening disease at an early stage is crucial for improving patient survival rates. The advancement in diagnostic technology has made disease identification faster and more accurate. Brain tumors are very critical and require prompt and precise detection for treatment. Deep learning algorithms can aid medical experts in diagnosis and treatment. Capsule Networks, a Deep Learning technique, have shown significant potential in medical diagnosis. The performance of capsule networks is driven mainly …

28.08.2026journal-article

World Journal of Gastroenterology

Helicobacter pylori promotes gastric cancer progression by upregulating EPS8L3 to inhibit ferroptosis

Meng-Di Ma, Wan-Jing Chen, Ke-Xun Yu, Hui-Zhen Wang, Yong-Xiang Li

BACKGROUND Gastric cancer (GC) represents one of the most prevalent malignancies globally and is ranked as the fourth leading cause of cancer-related mortality. Helicobacter pylori (H. pylori ) infection is a major risk factor for GC, however, the molecular mechanisms by which H. pylori promotes gastric carcinogenesis remain unclear. AIM To investigate how H. pylori promotes GC development by activating specific signaling pathways. METHODS Transcriptome sequencing identified epidermal growth factor receptor kinase …

28.08.2026journal-article

Frontiers in Pharmacology

Digital twin technology for HIV patient virtual modeling: a novel approach to treatment optimization

Yuan Zhang, Tingting Li, Jie Chen, Huanhuan Ba, Jiajia Li, Jinling Yin, Kangxiao Ma, Huanqing Liu, Juan Jin

Background Human immunodeficiency virus (HIV) infection remains a global health challenge, necessitating personalized treatment strategies to optimize patient outcomes. Digital twin technology—synchronized with real-world entities—offers a pathway to precision medicine in HIV care. Methods We analyzed 5,436 HIV patients (2016–2024) with demographic, immunologic, and antiretroviral therapy (ART) information. Core algorithms comprised gradient boosting and random forest ensembles; deep architectures (LSTM and Transfo …

28.08.2026journal-article

Frontiers in Cell and Developmental Biology

Single-cell transcriptomics deciphers cancer-associated fibroblast heterogeneity and immune regulatory mechanisms in the bladder cancer tumor microenvironment

Yandong He, Wenlong Lu, Guanqun Ju, Lin Chen

Background Bladder cancer (BLCA) is a common malignancy, with muscle-invasive bladder cancer (MIBC) associated with a 5-year survival rate below 50%. Cancer-associated fibroblasts (CAFs) are heterogeneous stromal components of the tumor microenvironment (TME) that contribute to tumor progression, therapy resistance, and immune evasion. However, the molecular basis of CAF diversity and immune regulation in BLCA remains incompletely understood. Methods We analyzed single-cell transcriptomic data from GEO dataset GSE1 …

28.08.2026journal-article

Medicine

Treatment of elderly patients with advanced (M1) gallbladder cancer – Aggressive or conservative?

Bin He, Ti Zhou, Penghua Weng, Haibin Lan

The optimal treatment strategy for elderly patients with distant metastatic gallbladder cancer (GBC, M1) remains controversial. We extracted data from the Surveillance, Epidemiology, and End Results (SEER) database for 528 elderly patients (aged ≥ 60 years) diagnosed with M1 GBC between 2000 and 2020. Patients were stratified by age (60–69, 70–79, ≥80 years) and treatment received: no surgery or chemotherapy (Group N), surgery alone (Group S), chemotherapy alone (Group C), or surgery combined with chemotherapy (Gro …

28.08.2026journal-article

Medicine

Traditional Chinese medicine treatment in a patient with severe COVID-19

Ming Zhong, Shiqi Sun, Fengjun Zhang, Wei Zhang

Rationale: Elderly patients with severe COVID-19 frequently develop chronic critical illness marked by prolonged ventilation, multidrug-resistant infections, enteral-nutrition (EN) intolerance, and persistent inflammation–immunosuppression–catabolism syndrome, making liberation from the ventilator and recovery difficult. Integrative Chinese and Western medicine (ICWM) is hypothesized to modulate immunity and the gut–lung axis and to stabilize frail physiology during long ICU courses. Patient concerns: An 87-year-ol …

28.08.2026journal-article

Clinical Cancer Research

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bushu Xu, Qiuzhong Pan, Ruiqing Peng, Desheng Weng, Jingjing Zhao, Xizhi Wen, Qiyan Cai, Wei Li, Hongcheng Hu, Ruihua Xu

Abstract Purpose: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase I results evaluating multiantigen stimulated cell therapy I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). Patients and Methods: Thirty-one patients with disease control after chemotherapy received MASCT-I alone (n = 17) or with ifosfamide (n = 14). The primary endpoint was safety. Secondary …

28.08.2026journal-article

Cancer Prevention Research

Barriers to Diagnostic Colonoscopy After a Positive Stool-Based Screening Test: A Scoping Review

Manali Patel, Paul Gerardo. Yeh, Thomas F. Imperiale, Victoria L. Champion, David R. Lairson

Abstract Non-invasive stool-based colorectal cancer (CRC) screening (e.g., fecal immunochemical test [FIT], guaiac fecal occult blood test [gFOBT], multitarget stool DNA [mt-sDNA]) reduces CRC mortality only when a positive result is followed by timely diagnostic colonoscopy. We synthesized barriers and facilitators to completing diagnostic colonoscopy after a positive stool-based screening test. Guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), …

28.08.2026journal-article

International Journal of Urology

Real‐World Outcomes of Olaparib in Japanese Patients With BRCA ‐Mutated Metastatic Castration‐Resistant Prostate Cancer: Exploratory Analysis of BRCA2 Loss and Microsatellite Instability Status

Takuhisa Nukaya, Taku Naiki, Hiromitsu Watanabe, Keita Nakane, Teruo Inamoto, Takahiro Yasui, Takuya Koie, Kiyoshi Takahara

ABSTRACT Objectives Metastatic castration‐resistant prostate cancer has a poor prognosis. Although olaparib has demonstrated efficacy in patients with BRCA1/2 mutations, real‐world data in Japanese patients remain limited. We aimed to evaluate the efficacy and safety of olaparib in patients with BRCA‐mutated metastatic castration‐resistant prostate cancer and explore the association of BRCA2 loss and microsatellite instability status with treatment outcomes. Methods We conducted a multicenter retrospective study of …