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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Innovation in Aging

An assessment of data and code sharing in research funded by the Nathan Shock Centers, 2017-2022: A meta-research study

Colby J Vorland, Simon Chung, Aidan S Kramer, John R Hultquist, David B Allison, Andrew W Brown

Abstract Background and Objectives Data and code sharing facilitate reproducibility, trust, and efficient reuse of research resources. Growing recognition of their importance among researchers, journals, and funders led the Nathan Shock Centers (NSC) Coordinating Center to propose documenting and supporting data and code sharing in aging research. As a baseline, we characterized data and code sharing practices in NSC-funded research. Research Design and Methods We surveyed articles citing NSC grants published 2017- …

13.08.2026journal-article

Metals

Effect of Aging Time on Tensile Properties of 7075 Aluminum Alloy

Yong Wang, Sawei Qiu, Tuo Ye, Qinghang Cui, Jiajun Han, Pengcheng Guo

A solid solution treatment (SST) followed by single-stage aging (0–30 h, 140 °C) was performed on 7075 aluminum alloy specimens with longitudinal axes oriented at 0°, 45° and 90° to the rolling direction. The mechanical properties and microstructure were analyzed by tensile testing, optical microscope (OM), electron backscatter diffraction (EBSD), scanning electron microscope (SEM) and transmission electron microscope (TEM). The results show that the average tensile strengths of the as-received 7075 aluminum alloy …

13.08.2026journal-article

JAMA Network Open

Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics

Sinthujah Vigneswaran, Inge M. W. Verberk, Lynn Boonkamp, Lisanne in ‘t Veld, Marleen J. A. Koel-Simmelink, Daniel Antwi-Berko, Luuk van Unen, Rebecca Rousset, Thomas Claessen, Marissa D. Zwan, Rik Ossenkoppele, David Wilson, Afina W. Lemstra, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Majon Muller, Francesco Mattace-Raso, Janne M. Papma, Harro Seelaar, Charlotte E. Teunissen, Argonde C. van Harten

Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181], glial fibrillary acidic protein [GFAP], and neurofilament light chain [NfL]) during multidisciplinary diagnostic meetings is associated with syndrome diagnosis, suspected etiology, and clinician confidence …

13.08.2026journal-article

Transplant Infectious Disease

Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End‐Stage Renal Disease

Kyle M. Crawford, Jillian Catalano, Dhriti Shah, Scott Curry, Alexandra G. Mills, Yosra Alkabab, Drew Charles, Courtney E. Harris, Ruth O. Adekunle

ABSTRACT Introduction People living with HIV (PLWH) have a higher incidence of end‐stage renal disease (ESRD) than HIV‐negative individuals and are less likely to receive a kidney transplant. We described attrition and delays across the transplant care continuum for PLWH with ESRD at the Medical University of South Carolina (MUSC) and explored factors associated with waitlisting. Methods Retrospective review of electronic health records of PLWH with ESRD who received care at MUSC or were referred for kidney transpl …

13.08.2026journal-article

Frontiers in Sports and Active Living

Physical environment as a catalyst for healthy aging: servicescape, motivation, and well-being in older adult park golf

Jaepil Seo, Kisun Hwang, Joonha Shin, Seung-Hwan Woo, Young-Kyun Sim

Background/objective Active leisure activities like park golf are crucial for older adults' successful aging. Grounded in the Stimulus-Organism-Response (S-O-R) paradigm and Self-Determination Theory (SDT), this study investigated the structural relationships among perceived servicescape, facility image, satisfaction, motivation, and subjective well-being. Methods A quantitative cross-sectional design was employed. Data from 264 older adult park golf participants in South Korea were analyzed using structural equati …

13.08.2026journal-article

Frontiers in Aging Neuroscience

Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China

Simeng Cui, Yu Zhang, Qiqi Qiang, Ziyu Liu, Peijie Liu, Liangjun Dang, Jin Wang, Wenhui Lu, Kang Huo, Yu Jiang, Chen Chen, Ling Gao, Shan Wei, Junlong Feng, Suixia Cao, Suhang Shang, Qiumin Qu, Meng Zhang

Background Obesity is a modifiable risk factor for cognitive impairment; however, body mass index fails to capture fat distribution. Waist-to-hip ratio (WHR), reflecting central adiposity, may better characterize obesity-related differences in cognitive impairment. Nevertheless, whether the association between WHR and cognitive impairment varies by sex and age remains unclear. Methods This cross-sectional study included 1,792 adults aged ≥40 years from rural China. Cognitive impairment was defined using education-a …

13.08.2026journal-article

HIV Medicine

Psychosocial vulnerabilities and loss to follow‐up in people living with HIV in France

Charlène Mafuta, Sophie Grabar, Laurence Lievre, Cécile Goujard, Jean‐Paul Viard, Olivier Bouchaud, Laurence Meyer, Rémonie Seng, Sophie Abgrall

Abstract Background Migration status is consistently associated with a higher risk of loss to follow‐up (LTFU). We investigated how sex, sexual orientation and social vulnerabilities affect the association between migration status and LTFU for hospital care in people living with HIV, using data from the ANRS CO9‐COPANA cohort linked to the nationwide French hospital database on HIV (ANRS CO4‐FHDH). Methods The COPANA prospective cohort enrolled antiretroviral drug‐naïve adults newly diagnosed with HIV‐1 between 200 …

13.08.2026journal-article

Revista de Geopolítica

RECONHECIMENTO DE SABERES E COMPETÊNCIAS NO PCCTAE: ENTRE A VALORIZAÇÃO DO TRABALHO REAL E A GESTÃO ESTRATÉGICA DE PESSOAS

Fernando Carlos Braga do Nascimento

O capítulo analisa o Reconhecimento de Saberes e Competências do Plano de Carreira dos Cargos Técnico-Administrativos em Educação (RSC-PCCTAE) como mecanismo de valorização remuneratória e como fonte potencial de conhecimento para a gestão estratégica de pessoas nas Instituições Federais de Ensino. Argumenta-se que o RSC amplia as formas de acesso ao Incentivo à Qualificação ao reconhecer saberes construídos no exercício profissional, sem romper com a estrutura remuneratória referenciada pela titulação formal. A pe …

13.08.2026journal-article

Signo y seña

Evaluación de la negación en personas con afasia

Virginia Jaichenco, María Elina Sánchez, Gary Libben, Sam Alxatib, Mira Goral

This study describes the design of a cross-linguistic battery for assessing negation in People with Aphasia (PWA). The battery is available in Spanish, English, Arabic, and Hebrew, and comprises four tests that evaluate different processing aspects: Sentence-Picture Matching (SPM), Anagram Task (AT), Sentence Repetition (REP), and Say the Opposite (SAY OP). The sensitivity of the battery was tested using two Spanish-speaking people with non-fluent aphasia. The results revealed a significant difficulty gradient in b …

13.08.2026journal-article

Antioxidants

Reduced Serum PON1 Lactonase Activity Is Associated with Mild Cognitive Impairment and Mixed Dementia

Raffaella Riccetti, Alessandro Trentini, Gianmarco Mola, Gloria Brombo, Dario Francesco di Paola, Massimiliano Castellazzi, Raffaella Candeloro, Maria Cristina Manfrinato, Giovanni Zuliani, Carlo Cervellati

High-density lipoprotein (HDL)-associated paraoxonase-1 (PON1) contributes substantially to the antioxidant and anti-inflammatory functions of HDL. Impairment of these protective properties has been associated with Alzheimer’s disease (AD) and other forms of dementia, particularly those involving neurovascular dysregulation. In the present study, we investigated for the first time the potential involvement of the putative physiological lactonase activity of PON1 in serum samples from a large cohort of older adults …

13.08.2026journal-article

Spinal Cord

Impact of respiratory muscle training on sleep disordered breathing in people with tetraplegia: a sub-analysis of a randomised controlled trial

Claire L. Boswell-Ruys, R. H. Chaminda Lewis, Rachel A. McBain, Nirupama S. Wijesuriya, Danny J. Eckert, Bonsan Bonne Lee, Simon C. Gandevia, Jane E. Butler

Abstract Study design Sub-analysis of a randomised controlled trial. Objectives Respiratory muscle training (RMT) in people with tetraplegia yields marked improvements in inspiratory muscle strength. The present study investigated whether RMT also modifies sleep disordered breathing (SDB) and daytime sleepiness. Setting Independent research institute in Sydney, Australia. Methods Sixty-two adults with tetraplegia underwent six weeks of supervised RMT. The active-RMT group trained the respiratory muscles through pro …

13.08.2026journal-article

Genes

MicroRNA Signature in Plasma-Derived Extracellular Vesicles in Frontotemporal Dementia

Evelyne Minucchi, Francesca Dragoni, Rosalinda Di Gerlando, Gaia Pavanello, Matteo Cotta Ramusino, Alfredo Costa, Stella Gagliardi

Background: Frontotemporal dementia (FTD) is a neurodegenerative disease that shares numerous clinical features with other forms of dementia. In this context, non-coding RNAs, specifically microRNAs (miRNAs), represent a promising tool for differential diagnosis. Since these miRNAs can be isolated from circulating extracellular vesicles (EVs) in peripheral blood, they provide a direct insight into FTD-specific molecular processes. Consequently, while EV-contained miRNAs hold potential as disease-specific biomarkers …

13.08.2026journal-article

Frontiers in Nutrition

Timing, continuity, and energy dose of oral nutritional supplements in older coronary care unit patients: associations with prognostic nutritional index trajectory and hospitalization burden

Shengquan Wang, Yu Zhang, Yanyu Yuan, Chen Huang, Ziwei Chen

Objectives Older adults account for a disproportionate share of coronary care unit (CCU) admissions, where acute cardiovascular instability, systemic inflammation, and nutritional deterioration converge. This single-center retrospective cohort study explored whether the timing, continuity, and daily energy dose of oral nutritional supplements (ONS) carry distinct associations with nutritional recovery and hospitalization burden in older CCU patients, to generate hypotheses for prospective investigation. Methods Thi …

13.08.2026journal-article

JAMA Network Open

Blood Biomarkers of Alzheimer Disease and Rates of Global and Domain-Specific Cognitive Decline

Erika J. Laukka, Ingrid Ekström, Martina Valletta, Bengt Winblad, Claudia Fredolini, Sarah Andersson, Laura Fratiglioni, Davide Liborio Vetrano, Giulia Grande

Importance While evidence is accumulating on blood-based biomarkers of Alzheimer disease (AD) and future cognitive decline, community-based studies that include phosphorylated tau (p-tau) 217 are still scarce. Moreover, there is limited knowledge regarding associations with domain-specific cognitive decline and modifying effects of key individual characteristics. Objective To investigate associations of blood biomarkers of AD with global and domain-specific cognitive decline. Design, Setting, and Participants This …

13.08.2026journal-article

Dementia

Design and Efficacy of Localized Non-Pharmacological Cognitive Materials: A Participatory Card-Game Intervention for Older Adults With Dementia in Taiwan

Shyh-Bao Chiang, Fang-Suey Lin, Jung-Ying Hou

Non-pharmacological interventions are widely recognised as essential components of dementia care. However, many cognitive activities lack cultural relevance and are difficult to integrate into everyday care practice. Design-driven approaches that emphasise cultural localisation and feasibility may offer an alternative pathway for meaningful engagement. To address this, this study employed a qualitative, practice-based design to develop and evaluate a culturally localised cognitive card-game intervention for older a …

13.08.2026journal-article

Perceptual and Motor Skills

Handedness Influences Subjective Memory Ratings but not Objective Memory Performance in Older Adults

Annukka K. Lindell

Handedness affects cognitive processing strengths. Consistent with the predominant right hemisphere motor control of the left hand, left-handed older adults have superior immediate and delayed visuospatial memory in comparison with right-handers. Investigations of handedness effects on verbal memory in older adults are, however, scarce and the findings inconsistent. The present study thus examined whether left-handed, right-handed and ambidextrous older adults differ in their subjective and objective verbal memory …

13.08.2026journal-article

Frontiers in Medicine

Association between frailty status and delayed observation-room retention after painless gastrointestinal endoscopy in older patients

Dongxu Sun, Tingting Feng, Wudong Zhuang, Yazhao Sun, Fang Xing

Background Frailty reflects reduced physiological reserve and may be associated with slower post-anesthesia recovery in older patients. This study examined the association between frailty status and delayed observation-room retention after painless gastrointestinal endoscopy and explored its additional discriminative contribution beyond routinely collected clinical and peri-procedural variables. Methods A total of 516 older patients undergoing painless gastrointestinal endoscopy were included, and all analyses repo …

13.08.2026journal-article

Frontiers in Public Health

Interpretable machine learning for identifying co-occurring internet addiction and maladaptive cognitive emotion regulation in older adults: a cross-sectional study

Jingrui Gui, Haiyue Chen, Jiazhao Li, Junrong Wang, Yihan Wang, Ruoxi Zhang, Xinya Zhang, Huashan Chen, Xu Zhang, Jing Zhang, Wenjuan Wang

Background Internet addiction and maladaptive cognitive emotion regulation may co-occur in later life, yet evidence-based approaches for identifying this co-occurrence remain limited. This study developed and interpreted a machine learning classifier to distinguish community-dwelling older adults with versus without current co-occurrence. A cross-sectional survey was conducted among 1,471 adults aged 60 years or older in China. Candidate predictors included demographic characteristics, general well-being, family fu …

13.08.2026journal-article

Journal of Burn Care & Research

A Matched Group Comparison of the Use of Autologous Skin Cell Suspension in Geriatric Burn Patients

Megan Newsom, Joseph Lewcun, Na Bo, Zachary Brown, Prabhu Senthil-Kumar, Michael Feldman

Abstract There is an increasing population of geriatric burn patients, and burns in this population are more morbid. Autologous skin cell suspension is an adjunct to autografting, which uses an 80:1 expansion of skin cells. The purpose of this investigation was to evaluate the ability of autologous skin cell suspension to augment wound healing in burn patients 65 years or older. We performed a single-center retrospective review of geriatric burn patients who underwent surgical treatment between January 2020 and Oct …

13.08.2026journal-article

Brazilian Journal of Medical and Health Sciences

Microbiota intestinal e suas relações com a doença de Alzheimer: uma revisão sistemática

Talles Vairo Magalhães

Esta revisão sistemática explora a relação entre a microbiota intestinal (MI) e a doença de Alzheimer (DA), uma condição neurodegenerativa caracterizada pelo acúmulo de placas βamiloides, neuroinflamação e disfunção da barreira hematoencefálica (BHE), levando a um declínio cognitivo progressivo e comprometimento da memória. Evidências sugerem que alterações na MI desempenham um papel relevante na patogênese da DA, tornando sua modulação uma estratégia terapêutica promissora. Com base nas diretrizes do PRISMA, foram …

13.08.2026journal-article

Information Technology & People

Determinants of pre-interaction swift trust and long-term adoption of care robots: the role of mind attribution and perceived similarity in eldercare robotics

Mahed Maddah, Shirin Hasavari, Shadi Esnaashari, Pouyan Esmaeilzadeh

Purpose The global eldercare crisis, driven by population aging and caregiver shortages, has accelerated interest in care companion robots. However, their integration into care settings depends partly on whether older adults are willing to trust unfamiliar robotic agents. Existing research has examined robot design, functionality and cultural acceptance, but has not fully integrated mind attribution and perceived relational alignment in explaining prospective trust and adoption intentions. This study therefore appl …

13.08.2026journal-article

Working with Older People

A community anchored integrated care pathway to address alternate level of care designation for older adults

Alicia Wickens

Purpose This study aims to examine Alternate Level of Care (ALC) pressures in Ontario as a health system design issue rather than solely a hospital flow problem, and to propose a Community-Anchored Integrated Care Pathway that addresses upstream determinants contributing to delayed transitions of care for older adults living with frailty. Design/methodology/approach This conceptual paper synthesizes evidence related to five upstream determinants of ALC pressures: early frailty identification, caregiver well-being, …

13.08.2026journal-article

Rehabilitation Counseling Bulletin

An Application of Rehabilitation Counseling Theory for Understanding Coping Among People With Alopecia Areata

Garrett E Huck, Yongsu Song, Kylee Kohlhoff, Emma Montero, Annika Covington, Shaina Baxter

Theories of rehabilitation counseling have enriched our understanding of individual responses to chronic disease and disability for nearly a century. Nevertheless, despite its prevalence and profound psychosocial impact, alopecia areata (AA) remains underrecognized in rehabilitation and health literature. This research aims to investigate the role of different coping styles on relationship-related and subjective quality-of-life outcomes among individuals with AA, considering Livneh’s conceptualization of psychosoci …

13.08.2026journal-article

Journal of Hypertension

Elevated urinary angiotensinogen excretion links incidence of chronic kidney disease among community-dwelling population: The Aging Kidney Study

Shun Yoshikoshi, Keisei Kosaki, Shoya Mori, Seiji Maeda, Makoto Kuro-o, Kunihiro Yamagata

Objectives: Activation of the intrarenal renin–angiotensin system (RAS) has been implicated in chronic kidney disease (CKD) pathophysiology. Although urinary angiotensinogen (AGT) is a noninvasive surrogate marker of intrarenal RAS activity, whether urinary AGT is associated with incident CKD remains unclear. We investigated the association between urinary AGT and incident CKD in community-dwelling adults without CKD. Methods: We conducted a prospective cohort study of community-dwelling adults without CKD. Urinary …