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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Surgery

Endoscopic diagnosis and treatment of colon cancer: current evidence and future directions

Huimei Gong, Hongyu Li, Zhiwen Zheng, Hanbin Zhu, Yanni Zhang

Colorectal cancer remains a major cause of cancer morbidity and mortality, while screening and advances in endoscopic imaging have increased detection of lesions that may be amenable to organ-preserving treatment. Accurate assessment of morphology, optical pattern, and invasion depth is central to selecting among endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR), and surgery. This structured narrative review synthesizes contemporary evidence and m …

01.09.2026journal-article

Clinical Spine Surgery

Radiologic Outcomes Following All-Pedicle Screw Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis Patients With Lenke Type 1 and 2 Curves

Shun Herng Tan, Chris Yin Wei Chan, Chee Kidd Chiu, Mohd Shahnaz Hassan, Mun Keong Kwan

Study design: Retrospective study. Objective: To evaluate the long-term clinical and radiologic outcomes of adolescent idiopathic scoliosis (AIS) patients with Lenke 1B, 1C, 2B, and 2C curves treated with selective thoracic fusion (STF) using an all-pedicle screw construct. Summary of Background Data: STF has been reported in the literature to achieve better perioperative outcomes, including shorter operative duration, reduced blood loss, and lower operative risks. However, complications such as coronal decompensat …

01.09.2026journal-article

Nature Medicine

Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction

Ruoyu Miao, Sungsam Gong, Ulla Sovio, Irving L. M. H. Aye, Giulia Avellino, Jacqueline Guettler, Stephanie N. Rogers, Emma Cook, Ana Toribio, Lina Bergman, Susanne Lager, Anna-Karin Wikström, IMPACT Consortium, Ylva Carlsson, Stefan R. Hansson, Peter Lindgren, Anders Larsson, Peter Conner, Alice Zancanaro, Marius Kublickas, Anna Sandström, Paul D. W. Kirk, D. Stephen Charnock-Jones, Gordon C. S. Smith

Abstract Preeclampsia and fetal growth restriction (FGR) are major causes of global morbidity and mortality. Both conditions are associated with impaired invasion of the uterus by extravillous trophoblast (EVT). We performed proteomics in maternal serum obtained at ~12 weeks of gestational age in a prospective pregnancy cohort (Pregnancy Outcome Prediction Study). Here we show that low maternal serum isthmin-2 (ISM2) was the strongest protein signal (out of 2,904) in the first trimester of pregnancy for preeclampsi …

01.09.2026journal-article

American Journal of Physiology-Lung Cellular and Molecular Physiology

Mechanical and chemical power and mortality in acute respiratory distress syndrome: an exploratory analysis of six patient cohorts

Thijs A. Lilien, Lieuwe D. J. Bos, Lukas Martin Mueller-Wirtz, Pien Swart, Siebe G. Blok, Luciano Cesar Pontes Azevedo, Giacomo Bellani, Michela Botta, Elisa Estenssoro, Eddy Fan, Juliana Carvalho Ferreira, Hendrik Helmerhorst, John G. Laffey, Ignacio Martin-Loeches, Ana Motos, Tai Pham, Óscar Peñuelas, Antonio Pesenti, Ary Serpa Neto, Emanuele Rezoagli, Antoni Torres, Anissa M. Tsonas, Frederique Paulus, Marcus J. Schultz, David M. P. van Meenen, Reinout A. Bem, for the ERICC-, LUNG SAFE-, PRoVENT-COVID-, EPICCoV-, CIBERESUCICOVID-, and SATI-COVID-19-Investigators

This observational study of a combined cohort of patients with acute respiratory distress syndrome assessed the association of the novel concept of chemical power, a surrogate marker of oxygen exposure intensity, with mortality and its relative weight in this association when compared with mechanical power. Chemical power and mechanical power were independently associated with mortality. An interaction between these powers was not observed. Future experimental studies should aim to validate and optimize this novel …

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

Primary pediatric cardiac tumors: a single-center experience from a high-volume pediatric cardiac center

Halise Zeynep Genç, Erkut Öztürk

Aim Cardiac tumors in children are rare and often asymptomatic. Nevertheless, in a subset of pediatric patients, they may lead to serious clinical conditions such as arrhythmia, outflow tract obstruction, or even death. This study aimed to evaluate the clinical characteristics, surgical management, and outcomes of pediatric patients diagnosed with cardiac tumors in a single high-volume pediatric cardiac center. Methods This retrospective study included all pediatric patients who underwent surgery for cardiac tumors …

01.09.2026journal-article

Journal of the European Society of Surgery

Clinicopathological Spectrum and Long-Term Outcomes of Appendiceal Neoplasms: A Bicentric Cohort Study

Haris Sulejmani, Blagica, Filip Vasilevski, Andrej Nikolovski

Background: Appendiceal neoplasms are rare and biologically heterogeneous, with diverse clinical presentations, pathological features, and treatment requirements. Their rarity has limited detailed real-world outcome data, particularly from smaller health-care systems. Methods: We conducted a retrospective bicentric cohort study of patients with histologically confirmed appendiceal neoplasms treated at two tertiary surgical centres in Skopje, North Macedonia, between January 2016 and May 2026. Patients with appendic …

01.09.2026journal-article

Eurasian Clinical and Analytical Medicine

Clinical outcomes and replant survival after microsurgical replantation following traumatic single-digit amputation

Mehmet Melih Asoglu, Volkan Kizilkaya, Ali Levent, Emre Mücahit Kartal

Aim Traumatic single-digit amputations may appear limited in extent, yet they can seriously impair hand function and quality of life. Factors determining survival of the replanted digit and functional recovery remain debated. We aimed to report our replantation outcomes and identify factors associated with replant survival. Methods Sixty patients who underwent microsurgical replantation for single-finger amputation between January 2020 and January 2025 were reviewed retrospectively. Patients were grouped according …

02.09.2026journal-article

Therapeutic Advances in Infectious Disease

Doravirine and islatravir for HIV-1 treatment: A systematic review and meta-analysis with GRADE assessment

Muhammad Tayyab Azam, Muhammad Hussain Azam, Muhammad Arif Khan, Muhammad Hassan Azam, Zain Ul Abideen Shahid, Shahzad Ashraf, Syeda Momina Umer, Rabeea Arshad, Hasibullah Aminpoor, Hammad Javaid

Background Two-drug antiretroviral regimens are increasingly explored to simplify HIV-1 treatment while maintaining durable viral suppression. Doravirine combined with Islatravir (DOR/ISL) represents a novel non-integrase strand transfer inhibitor (non-INSTI) regimen. However, comprehensive synthesized evidence remains limited. Objectives To systematically evaluate the efficacy and safety of fixed-dose Doravirine (100 mg) plus Islatravir (0.25 or 0.75 mg) for HIV-1 treatment in adults. Design Systematic Review and …

01.09.2026journal-article

ASEAN Journal of Rehabilitation Medicine

Cross-Cultural Adaptation and Psychometric Properties of the Thai Version of the Short-Form Urinary Quality of Life Questionnaire (SF-Qualiveen) in Individuals with Neurogenic Lower Urinary Tract Dysfunction Following Spinal Cord Injury

Pasinee Theerapap, Chayaporn Chotiyarnwong, Thanitta Thanakiatpinyo

Objectives: To develop the Thai version of the short form of the Urinary Quality of Life Questionnaire (SF-Qualiveen) and evaluate its validity and reliability in patients with neurogenic lower urinary tract dysfunction following spinal cord injury Study design: Cross-cultural adaptation and psychometric validation study Setting: Department of Rehabilitation Medicine, Faculty of Med-cine Siriraj Hospital, Mahidol University, Thailand, a tertiary care university hospital Participants: Patients with spinal cord injur …

01.09.2026journal-article

National Journal of Community Medicine

Quality of Life and Its Determinants among Patients on Vitamin K Antagonist Therapy in India: A Baseline Cross- Sectional Analysis

Janet Prameela Dsouza, Jyothi Chakrabarty, Padmakumar Ramachandran, Baby S Nayak, Elsa Sanatombi Devi, Vasudeva Guddattu, Judith Angelitta Noronha Noronha

Background: Vitamin K Antagonist (VKA) therapy has been extensively recommended for years to prevent thromboembolic disorders. The continued use of this treatment emphasizes its clinical importance across healthcare settings, particularly in resource-limited countries such as India. Chronic use of this therapy can impact patients’ QOL owing to treatment-related burden. Given that limited data are available related to the QOL of patients on VKA therapy at tertiary referral hospitals in the region, this study was und …

03.09.2026journal-article

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

Associated Determinants of Sexual Dysfunctions in Non-Specific Low Back Pain Patients in Cameroon: A Cross-Sectional Study

Womsi Tatuegan Ruslaine, Wankeu-Nya Modeste, Mekoulou Ndongo Jerson, Djeumeni Néely Ornéla, Watcho Pierre, Massoma Dieudonné Lembè

Background: Non-specific low back pain (NSLBP) is a significant factor involved in the onset of sexual dysfunctions (SDs). However, studies demonstrating the correlation between these 2 conditions are rare. This study aimed to determine the prevalence and factors associated to SDs in patients suffering from NSLBP in Cameroon. Method: A cross-sectional study was conducted among patients suffering from NSLBP in the 3 main town (Yaoundé, Douala and Bafoussam) of Cameroon. Clinical characteristics and sexual activity o …

03.09.2026journal-article

Journal of Veterinary Internal Medicine

Post-marketing safety monitoring of sodium-glucose cotransporter 2 inhibitors for diabetes in cats: a pharmacovigilance study based on the FDA ADAE database

Xiaoheng Lai, Maohua Chen, Yaping Huang, Yu Cheng

Abstract Background Bexagliflozin and velagliflozin are currently the only sodium-glucose cotransporter 2 inhibitors approved by the United States Food and Drug Administration (FDA) for treating diabetes in cats. There are limited real-world safety reports on their associated adverse events (AEs). Hypothesis/Objectives To analyze AEs associated with bexagliflozin and velagliflozin using real-world data from the FDA Animal Drug Adverse Events (ADAE) database. Animals None. Methods AE reports submitted for cats recei …

01.09.2026journal-article

The Professional Medical Journal

SOX10 immunohistochemical stain in differential diagnosis of posterior fossa tumors, a single centered study.

Ayesha Iftikhar, Sajid Mushtaq, Asif Loya, Usman Hassan, Hina Maqbool, Shaarif Bashir

Objective: To evaluate the diagnostic utility of SOX10 immunohistochemical staining in distinguishing posterior fossa tumors, particularly ependymomas and non-ependymomas. Study Design: Cross-sectional study. Setting: Department of Histopathology, Shaukat Khanam Memorial Cancer Hospital and Research Center, Lahore. Period: March 2025 to August 2025. Methods: This cross sectional study included 65 posterior fossa tumors. 33 ependymomas and 32 non-ependymomas: pilocytic astrocytoma, medulloblastoma, meningioma, diffu …

06.09.2026journal-article

Cancer Medicine

Construction and Validation of a Progression‐Free Survival Prediction Model for Newly Diagnosed Multiple Myeloma Patients With 1q21 Gain/Amplification

Yuexuan Rao, Shiyou Li, Aoyang Yu, Wenjie Yu, Zhiyuan Yao, Huanxin Zhang, Zhenyu Li

ABSTRACT Objective To investigate the clinical characteristics of newly diagnosed multiple myeloma (NDMM) patients with 1q21 gain/amplification (1q21+), construct and validate a progression‐free survival (PFS) prediction model, and explore the clinical implications of model‐based risk stratification. Methods We retrospectively analyzed 186 newly diagnosed multiple myeloma patients with 1q21+ treated between 2018 and 2024. Patients were randomly assigned at a 7:3 ratio to a training cohort ( n = 131) and an internal …

06.09.2026journal-article

Clinical Cardiology

Prospective Evaluation of Quality‐of‐Life Improvement After Dapagliflozin Initiation in a Greek Population With HFrEF: The EVOLUTION‐HF 12‐Month Results

Victoria Potoupni, Aristi Boulmpou, Spyridon Maragkoudakis, Alexandros Briasoulis, Emmanouil Foukarakis, Alexia Stavrati, Konstantinos Papadopoulos, Katerina K. Naka, Anna Kotsia, Ioannis Parissis, Antonios Ziakas, Stamatis Adamopoulos, Dimitrios Tziakas, Sotirios Patsilinakos, Melanie Konstantinidou, Periklis Davlouros, Zacharias Christogiannis, Konstantinos Tsitlakidis, Ioannis Pantelakis, Georgios Stefanakis, Marios Kolios, Ioannis Baltogiannis, Evangelos Voltyrakis, Christos Varounis, Andreas Samothrakitis, Dimitrios Krikidis, Panagiotis Tsialoukis, Zoe Paparepa, Dimitrios Gourlis, Nikolaos Papoutsidakis, Apostolos Karavidas, Christodoulos Papadopoulos

ABSTRACT Introduction Heart failure with reduced ejection fraction (HFrEF), defined by a left ventricular ejection fraction ≤ 40%, remains a major global health challenge, associated with substantial morbidity, mortality, and impaired quality of life (QoL), particularly in patients with higher NYHA class. Sodium–glucose cotransporter‐2 (SGLT2) inhibitors have emerged as a cornerstone therapy for HFrEF, significantly reducing hospitalizations and mortality regardless of glycemic status, sex, race, or comorbidities. …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Autosomal Dominant Hyper-IgE (Job) Syndrome Presenting with Recurrent Pulmonary Infections and Empyema in a Child: A Case Report

Shashank Mishra, Santosh Dey, Kamal Kishore, Amit Pandey

Hyper-IgE syndrome (HIES), also known as Job syndrome, is a rare primary immunodeficiency characterised by recurrent cutaneous and pulmonary infections, chronic eczematous dermatitis, and markedly elevated serum immunoglobulin E levels. The Autosomal Dominant (AD) form, resulting from mutations in the Signal Transducer and Activator of Transcription 3 (STAT3) gene, is the most frequently encountered variant and is associated with significant infectious morbidity, particularly involving the respiratory system. The p …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF ANATOMY RADIOLOGY AND SURGERY

Temporal Pattern and Frequency of Ileostomy-related Complications: A Prospective Observational Study

Ivneet Kaur, Rana Ranjit Singh, Arun Kumar Gupta, Prabhjot Kaur Gill

Introduction: Ileostomy is frequently performed to divert faecal flow and protect distal bowel anastomoses in both elective and emergency surgical settings. However, postoperative complications remain a significant cause of morbidity and may affect patient recovery. Aim: To evaluate the frequency and temporal pattern of complications following ileostomy during the first 12 weeks after surgery. Materials and Methods: This prospective observational study was conducted in the Department of General Surgery, Sri Guru Ra …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Anaesthetic Management of Multivalvular Surgery Complicated by Submitral Aneurysm and Pulmonary Hypertension: A Case Report

Abhigna Gummalla, Vivek Chakole, Amreesh Paul Francis

Submitral Aneurysm (SMA) is a rare cardiac condition that presents with perioperative anaesthetic complications, especially with comorbidities such as Pulmonary Hypertension (PH) and severe valvular disease. The case reported is a 21-year-old female with a medical illness history of rheumatic heart disease, severe mitral and Tricuspid Regurgitation (TR), PH, and basal SMA. She was admitted with palpitations, dyspnoea, and cough. Preoperative assessment revealed ventricular dysfunction and pulmonary disease. She was …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Clinical Spectrum and Severity of Mycoplasma pneumoniae Infection in Children From a Rural Tertiary Centre: A Case Series

Ruchika Suresh Kannake, Smita Jategaonkar, Varsha Chauhan, Manish Jain

Mycoplasma pneumoniae, a common cause of Community Acquired Pneumonia (CAP) in children is traditionally considered a mild illness. Increasing evidence suggests broader clinical spectrum with significant respiratory and extrapulmonary involvement. This case series consists of 20 hospitalised children with laboratory-confirmed M. pneumoniae infection at rural tertiary care centre. Diagnosis was confirmed using respiratory Real-time Polymerase Chain Reaction (RT-PCR) in all patients, with serology performed in four c …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

One Lung Ventilation and Erector Spinae Plane Block in a Child with Posterior Mediastinal Tumour: A Case Report

Neeta Verma, Prachi Siddharth Kamble

Tumours located in the posterior mediastinum of children present unique anaesthetic challenges because they are in proximity to large vessels and the airway, which puts the child at risk for airway compression, difficulty breathing, and loss of haemodynamic stability during surgery. This case describes the perioperative anaesthetic management of this eight-year-old girl, weighing 23 kg, with a large ganglioneuroma that extended from D1 to D7 in the posterior mediastinum. Because of the risk of airway compromise, an …

01.09.2026journal-article

Journal of Clinical Sport Psychology

Validity Evidence of the Brazilian Version of Characteristics of Resilience in Sports Teams Inventory

Mylena Aparecida Rodrigues Baransk, José Roberto Andrade do Nascimento Junior, Mauro Moreira dos Santos, Gabriel Lucas Morais Freire, Lorcan Donal Cronin, Daniel Perez Arthur, Joice Mara Facco Stefanello

This multistudy research aimed to adapt and validate the Characteristics of Resilience in Sports Teams Inventory for the Brazilian sports context. The study involved four translators, 25 athletes in the pilot study, five experts, and 1,155 athletes (581 females and 574 males) from team sports, such as basketball, soccer, futsal, American football, handball, volleyball, and beach soccer. In Study 1, all Characteristics of Resilience in Sports Teams Inventory for the Brazilian sports context items achieved coefficien …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Bone Marrow Metastasis as an Initial Manifestation of Gastric Carcinoma: A Rare Case Report

Milan Tripathy, Prita Pradhan, Ranjita Panigrahi, Shivam ., Shubham Jainwar, Bangam Rajendra Prasad Rao

Gastric adenocarcinomas, despite being a leading contributor of cancer-related mortality, presentation directly with Bone Marrow (BM) infiltration sans prior Gastrointestinal (GI) symptoms holds sparse documentation in existing literature. Though a rare phenomenon, BM studies play a pivotal role in the presentation and management of such cases. This case report describes a 36-year-old female with worsening generalised body pain accompanied by fever. Radiologic evaluation revealed multiple lytic lucencies in the ver …

01.09.2026journal-article

Physician Leadership Journal

Ethical Leadership in Healthcare: A Multilevel Framework for Physician Leaders

William Martin

Physician leaders face unprecedented ethical challenges navigating healthcare’s transformation — from artificial intelligence implementation to private equity acquisitions, from clinician burnout to organizational pressures prioritizing financial metrics over patient care. Although leadership ethics are critical to organizational culture and patient outcomes, physician-specific ethical leadership frameworks remain scarce. This article proposes a comprehensive, multilevel conceptual framework grounded in organizatio …

01.09.2026journal-article

Journal of Iranian Medical Council

Health Professionals’ Responses to Patient Gift-Giving

Shahriar Mousavinejad, Erfan Mahjoob Khaligh, Mirsaeed Attarchi, Kourosh Delpasand

Background: Healthcare professionals› acceptance of gifts poses ethical dilemmas, potentially biasing clinical decisions and eroding public trust. The aim of this study is to investigate the prevalence, motivations, and responses to gift-giving among healthcare staff. Methods: An analytical cross-sectional study was conducted at Razi Hospital, Rasht, from January to June 2024. Convenience sampling was used to recruit physicians, nurses, and residents. A valid questionnaire was used to collect data. The validity was …