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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Frontiers in Public Health

Openness influences emotion recognition in middle-aged and older adults through hippocampal volume and fluid intelligence: a serial mediation model

Yan Wang, Libin Song, Pang Jin, Bo Zhou

Background Openness to experience is positively associated with emotion recognition ability in middle-aged and older adults, yet the underlying neurocognitive mechanisms remain unclear. Methods Using a serial mediation model, the present study examined the neurocognitive pathways through which openness to experience influences emotion recognition accuracy and processing speed via hippocampal volume and fluid intelligence in 912 middle-aged and older adults aged 36–100 years, with age, sex, intracranial volume, and …

13.08.2026journal-article

Journal of Applied Physics

The effect of aging and charge variability on the detonation performance of a conventional plastic-bonded high explosive

Carlos Chiquete, Eric K. Anderson, Scott I. Jackson

Plastic-bonded explosives (PBXs) are pressed composites of energetic crystals (>90 wt. %), polymeric binder, and an internal porosity structure (1–2 vol. %). The binder ensures material stability, while porosity promotes more reliable reaction initiation. These microstructural features critically influence the bulk mechanical and detonation performance properties of the high explosive (HE), yet the connection between microstructure and bulk behavior remains incompletely understood, complicating both manufacture and …

13.08.2026journal-article

Frontiers in Microbiology

High-fructose diet–induced gut dysbiosis as a mechanistic driver of chronic inflammation and accelerated biological aging: a comprehensive review

Xin-zhu Xu, Mo-si Dong, Jian-yu Dai, Qing-yan Wang, Xuan-chi Dong, Ying Jin

High-fructose diet (HFD) has emerged as a critical dietary risk factor for metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This review delineates the molecular mechanisms underlying the pathological cascade linking high-fructose intake, gut dysbiosis, chronic inflammation, and accelerated aging. At the metabolic level, excess fructose is rapidly phosphorylated by ketohexokinase (KHK), depleting intracellular ATP while driving overproduction of uric acid and reactive oxygen …

13.08.2026journal-article

International Journal of Innovative Science and Research Technology

Prediction of Geriatric Patients Readmission Using XGBoost

Aisha Al- Mustapha, Prema Kirubakaran, Ridwan Koladapo, Kosiso Precious Nwajiobi

Hospital readmission among geriatric patients is a critical indicator of healthcare quality, imposing significant burdens on both patients and healthcare systems. This study proposes an Extreme Gradient Boosting (XGBoost)-based predictive framework for identifying 30-day hospital readmission risk in patients aged 65 years and above.

13.08.2026journal-article

Revista Confluencia

Nivel de conocimiento y percepción de sexualidad saludable en personas mayores autovalentes: Estudio descriptivo en Chillán, Chile

Giselle Pérez Salgado, Cristina Pérez Salgado, Carla Sandoval Astudillo, Fernanda Sepúlveda Aravena, Melanie Vásquez Molina, Patricia Rojas Salinas, Guillermina Mora Bustamante

Introduction: The concerns of age-related changes, leaving aside some factors associated with health, this study aims to the level of knowledge about healthy sexuality in self-reliant seniors attending the More Self-sufficient Senior program at four Family Health Centers in the City of Chillán, 2024. Methodology: A quantitative, observational descriptive study was conducted. The population consists of 779 elderly persons over 60 years enrolled in the program. A non-probabilistic sample is calculated for convenience …

13.08.2026journal-article

PLANTS, PEOPLE, PLANET

Within‐tree spatial heterogeneity of sap flow velocities and wood properties and its effect on the uncertainty of tree level sap flux estimates

Stefan Seeger, Markus Weiler, Martin Maier

Societal Impact Statement As forests are important for biodiversity and recreation and provide vital resources globally, it is essential that their health can be accurately monitored, for example, by using sap flow probes to measure tree water uptake. We investigated whether sap flow measurements might differ at various locations within the same tree due to variation in wood properties. We found high variability in sap flow measurements across one tree, meaning that accurate measurements might require a large numbe …

13.08.2026journal-article

Formosan Journal of Musculoskeletal Disorders

Perioperative Implant-associated Fractures in Geriatric Pertrochanteric Fixation: Incidence, Risk Factors, and the Influence of Proximal Femoral Geometry

Jiun-Jen Yang, Chih-Yang Lai, Ping-Jui Tsai, Chang-Heng Liu, Yi-Hsun Yu

Abstract Background: Perioperative implant-associated fractures (PIAFs) are defined as new cortical or structural disruptions occurring during nail insertion and represent an under-recognized complication associated with cephalomedullary nailing in geriatric pertrochanteric fractures. Objectives: This study aimed to evaluate the incidence, associated factors, and radiographic characteristics of PIAFs in a consecutive cohort. Materials and Methods: A retrospective review was conducted on 258 patients aged ≥60 years …

13.08.2026journal-article

Clinics and Practice

Calcaneal Insufficiency Fracture: An Underrecognized Cause of Atraumatic Heel Pain in Older Adults

Koji Nozaka, Naohisa Miyakoshi

Background/Objectives: Calcaneal insufficiency fractures may be overlooked in older adults presenting with atraumatic heel-region pain because early radiographic findings can be absent or inconclusive. Evidence regarding how often these fractures are identified in routine outpatient practice remains limited. This study aimed to describe the observed frequency, diagnostic pathway, clinical characteristics, treatment, and documented clinical course of calcaneal insufficiency fractures in an orthopaedic outpatient coh …

13.08.2026journal-article

Sexes

Transcendent Lobbying: Jewish Prayer for Trans People as Resilience, Embodiment, and Sacred Alignment

Elazar Ben-Lulu

In recent years, scholarship has increasingly explored the intersections of theology, liturgy, and transgender identities. At the same time, transgender individuals continue to encounter resistance, exclusion, and stigmatization within many religious settings, where gender diversity is frequently framed as incompatible with established theological norms. Against this backdrop, this study examines the emergence of contemporary non-Orthodox Jewish prayers written by and for transgender and non-binary individuals. Dra …

13.08.2026journal-article

Advanced Electromagnetics

Analysis of Cost Control and Quality Improvement Paths for Geriatric Elderly Care Services under Long-term Care Insurance

Q. Yuan, Y. W. Long, W. Y. Xie

Efficient management of large-scale service systems requires robust information integration, intelligent resource allocation, and data-driven decision support. This study proposes a cost-control and quality-optimization framework based on multimodal data fusion, efficiency evaluation, and simulation-driven decision analysis. Heterogeneous information from administrative records, clinical indicators, caregiver surveys, and policy datasets is integrated through a unified data-processing architecture to support compre …

13.08.2026journal-article

BMC Pulmonary Medicine

Age-related effects of comprehensive in-patient physiotherapy after lung cancer surgery across age groups: an ambispective observational cohort study in middle-aged and older patients

Ayse Sena Manzak Dursun, Betul Cinar, Fuat Gökdemir, Omer Soysal, Alis Kostanoğlu

Abstract Background Postoperative recovery after lung cancer surgery may be influenced by age, comorbidity burden, and perioperative rehabilitation strategies. However, evidence regarding the age-related effects of structured early inpatient physiotherapy programs remains limited. This study aimed to evaluate the age-related effects of a comprehensive in patient physiotherapy (CIPT) program on hospital length of stay (LoS), clinical parameters, symptom-related outcomes, and inflammatory biomarkers in patients under …

13.08.2026journal-article

npj Aging

Interpretable epigenetic clock links aging pathways and disease-specific methylation profiles

Rajarshi Mandal, Ning Xie, Gil Alterovitz

Abstract We developed an interpretable blood-based epigenetic clock to estimate DNA methylation age and identify disease-specific DNA methylation alterations. Using 8233 Illumina methylomes from healthy controls and nine age-associated diseases, we used ridge selection to retain 4855 CpG sites and benchmarked 20 regression architectures with Bayesian hyperparameter optimization. Tree-based boosting models performed best, and a weighted ensemble achieved a mean absolute error of 2.54 years on held-out test data, out …

13.08.2026journal-article

Cells

Potential Roles of Cellular Senescence and Inflammaging in Prostate Cancer: Aging Microenvironment, Immune Remodeling, and Therapeutic Implications

Qiuyang Zhang, Keyi Shen, Sen Liu

Prostate cancer is common in older men, yet mechanisms linking aging to tumor progression remain incompletely defined. Beyond genetic alterations, aging reshapes the prostate microenvironment through cellular senescence, chronic low-grade inflammation, immune dysfunction, stromal remodeling, metabolic stress, and impaired tissue repair, collectively promoting inflammaging. This persistent inflammatory state may create a permissive niche for tumor initiation, progression, immune evasion, and treatment resistance. Se …

13.08.2026journal-article

Frontiers in Aging

Age-related differences in BMD response during three years of denosumab treatment

Koji Ishikawa, Tomoyuki Asada, William Richardson, Choiselle Marius, Mahoko Ishikawa, Tuyet Nguyen, Philip Varnadore, Soji Tani, Peter Passias, Benjamin Aaron Alman

Introduction Denosumab increases bone mineral density and reduces fracture risk in patients with osteoporosis. However, whether BMD response to denosumab differs by age, particularly during longer term treatment, remains unclear. This study investigated the association between baseline age and BMD gain during 3 years of denosumab treatment in patients with osteoporosis. Methods This retrospective study included patients with osteoporosis who were treated with denosumab. DXA-based BMD and bone turnover markers were …

13.08.2026journal-article

European Journal of Sport Science

Effects of Fast Rhythmic Auditory Pacing on the Exercise Intensity of a Cognitive–Motor Training in Older Adults

Mingyi Ye, Vilma Gómez, Sean Mullen, Jeffer E. Sasaki, Rodrigo Vitório, Gustavo Christofoletti, Emerson Sebastião

ABSTRACT This study examined the objective and perceived exercise intensity and movement volume during an acute session of a cognitive‐motor training, namely, square‐stepping exercise (SSE), in older adults under two pacing conditions and three step‐pattern complexities. Thirty older adults (73.6 ± 7.4 years) completed SSE under normal pace (Normal) and externally paced (Paced; 150% of normal walking speed) conditions in randomized order. For each condition, participants performed three different step patterns for …

13.08.2026journal-article

Neuropsychopharmacology

The effect of theta-gamma coupling on response to cognitive remediation combined with transcranial direct current stimulation in older adults at high risk for dementia: a PACt-MD secondary analysis

Heather Brooks, Mina Mirjalili, Clement Ma, Daniel M. Blumberger, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Sanjeev Kumar, Krista Lanctôt, Linda Mah, Benoit Mulsant, Bruce G. Pollock, Nicole Schoer, Reza Zomorrodi, Tarek K. Rajji

Abstract The PACt-MD study demonstrated that combined cognitive remediation (CR) and transcranial direct current stimulation (tDCS) slows global cognitive decline in individuals with mild cognitive impairment (MCI) or remitted major depressive disorder (rMDD) over a median follow-up of four years. Prefrontal theta-gamma coupling (TGC), measured via electroencephalography (EEG), is a marker of prefrontal cortical function and may index cognitive compensation, the mechanism thought to underlie CR+tDCS effects. This s …

13.08.2026journal-article

Transactions of the Royal Society of Tropical Medicine and Hygiene

Molecular detection of pulmonary tuberculosis and Candida albicans co-infection in people living with HIV/AIDS in Nigeria

Fatima Muhammad Sani, Ahmad Adamu Yarma, Lawal Garba, Shuaibu Isa, Muhammad Tukur Adamu, Taofiq Abdullahi Umar, Salawaudeen Adamu, Idris Nasir Abdullahi

Abstract Objectives Concurrent pulmonary tuberculosis (PTB) and antifungal-resistant candidiasis pose significant clinical and public challenges in resource-limited settings. This study determined the prevalence of PTB and antifungal-resistant Candida albicans co-infection among people living with HIV/AIDS (PLWHA) in Gombe State, Nigeria. Methods Sputum samples from 348 PLWHA were processed and tested for Mycobacterium tuberculosis using GeneXpert equipment. Moreover, C. albicans was isolated and identified using C …

13.08.2026journal-article

Nursing Reports

Healthcare Access for Older Indigenous Women in Latin America: A Scoping Review of Barriers, Facilitators, and Knowledge Gaps

Francisco Javier Arroyo-Cruz, Karina Isabel Casco-Gallardo, Edith Araceli Cano-Estrada, Benjamín López-Nolasco, Abigahid Vianey Morales-Ortiz, Claudia Atala Trejo-García, José Antonio Guerrero-Solano

Background: Over recent decades, Latin America has undergone significant population aging, accompanied by persistent inequalities that adversely affect healthcare access, particularly among Indigenous populations. This scoping review aimed to map and synthesize the available evidence on healthcare access for older Indigenous women in the region, identifying relevant dimensions, barriers, facilitators, and existing knowledge gaps. Methods: A systematic search was performed in scientific databases and gray literature …

13.08.2026journal-article

Journal of Electrochemical Energy Conversion and Storage

Electrode Architecture Effects on Lithium-Ion Battery Aging: A Pseudo-Two-Dimensional Modeling Approach

Irene Giusti, Marella De Santis, Federico Poli, Luca Piancastelli, Alfredo Liverani

Abstract This study investigates the electrochemical performance and aging behavior of lithium-ion batteries (LIBs), focusing on the architectural effects of electrode and separator geometries alongside active material particle sizes. A pseudo-two-dimensional (P2D) model is employed to simulate lithium intercalation, solid diffusion, and coupled thermal behavior across a full-factorial design space. Despite its one-dimensional formulation, the model provides an optimal balance between computational efficiency and c …

13.08.2026journal-article

Journal of Functional Morphology and Kinesiology

Efficacy and Cost-Effective Treatment of Isometric Resistance Training for Blood Pressure Control: A Narrative Review in Healthy Individuals and People with Cardiovascular Diseases

Matteo Vitarelli, Domenico Mario Giamundo, Alberto Grossi, Giuseppe Caminiti, Gabriele Morganti, Francesca Strassoldo di Villanova, Bruno Ruscello, Elvira Padua, Maurizio Volterrani, Valentina Morsella, Marco Alfonso Perrone, Vincenzo Manzi, Gennaro De Rosa, Lorenzo Loffredo, Enrico Maggio

Isometric resistance training (IRT) has emerged as a promising non-pharmacological intervention for blood pressure (BP) management. Although current hypertension guidelines primarily recommend aerobic and dynamic resistance exercise, growing evidence indicates that IRT is an effective, feasible, and time-efficient alternative. This narrative review summarizes the current evidence on the efficacy, physiological mechanisms, and clinical applications of IRT. We reviewed randomized controlled trials, systematic reviews …

13.08.2026journal-article

Journal of Clinical Medicine

Comparative Analysis of the ASA-PS Score and Clinical Frailty Scale in Predicting Postoperative Intensive Care Unit Requirement in Geriatric Hip Fracture Surgery: A Retrospective Evaluation

Dilek Kalaycı, Tuğba Aşkın

Background/Objectives: Identifying geriatric hip fracture patients who will require postoperative intensive care unit (ICU) admission remains a clinical challenge. The American Society of Anesthesiologists Physical Status (ASA-PS) classification and the Clinical Frailty Scale (CFS) are both used in preoperative risk stratification, yet their comparative utility for this purpose has not been well characterized. Methods: This single-center, retrospectively designed study included 243 patients aged 65 years or older w …

13.08.2026journal-article

Innovation in Aging

An assessment of data and code sharing in research funded by the Nathan Shock Centers, 2017-2022: A meta-research study

Colby J Vorland, Simon Chung, Aidan S Kramer, John R Hultquist, David B Allison, Andrew W Brown

Abstract Background and Objectives Data and code sharing facilitate reproducibility, trust, and efficient reuse of research resources. Growing recognition of their importance among researchers, journals, and funders led the Nathan Shock Centers (NSC) Coordinating Center to propose documenting and supporting data and code sharing in aging research. As a baseline, we characterized data and code sharing practices in NSC-funded research. Research Design and Methods We surveyed articles citing NSC grants published 2017- …

13.08.2026journal-article

Metals

Effect of Aging Time on Tensile Properties of 7075 Aluminum Alloy

Yong Wang, Sawei Qiu, Tuo Ye, Qinghang Cui, Jiajun Han, Pengcheng Guo

A solid solution treatment (SST) followed by single-stage aging (0–30 h, 140 °C) was performed on 7075 aluminum alloy specimens with longitudinal axes oriented at 0°, 45° and 90° to the rolling direction. The mechanical properties and microstructure were analyzed by tensile testing, optical microscope (OM), electron backscatter diffraction (EBSD), scanning electron microscope (SEM) and transmission electron microscope (TEM). The results show that the average tensile strengths of the as-received 7075 aluminum alloy …

13.08.2026journal-article

JAMA Network Open

Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics

Sinthujah Vigneswaran, Inge M. W. Verberk, Lynn Boonkamp, Lisanne in ‘t Veld, Marleen J. A. Koel-Simmelink, Daniel Antwi-Berko, Luuk van Unen, Rebecca Rousset, Thomas Claessen, Marissa D. Zwan, Rik Ossenkoppele, David Wilson, Afina W. Lemstra, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Majon Muller, Francesco Mattace-Raso, Janne M. Papma, Harro Seelaar, Charlotte E. Teunissen, Argonde C. van Harten

Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181], glial fibrillary acidic protein [GFAP], and neurofilament light chain [NfL]) during multidisciplinary diagnostic meetings is associated with syndrome diagnosis, suspected etiology, and clinician confidence …