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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Angewandte Chemie International Edition

Raising the Mayan Pyramids: Construction of Polyoxothiomolybdates via In Situ Sulfurization for Enhanced Antitumor Therapy

Zi‐Yu Xu, Dao‐Jing Yuan, Lin‐Jie Lan, Yue Zhao, Ke‐Wei Tong, Chao‐Qin Chen, Pan‐Chao Yin, Jing Du, Teng Gong, Peng Yang

ABSTRACT The advancement of atomic‐level sulfurization technology is ushering materials engineering from coarse regulation toward precise editing. As represented by polyoxothiometalates (POTMs), the available sulfurization methods remain limited and nongreen, imposing severe constraints on their structural diversity and functional applications. In this study, an in situ sulfurization approach was developed to construct the Mo‐based POTMs (POTMos) in a distinct and eco‐friendly manner. The emergence of unprecedented …

02.09.2026journal-article

Australian Occupational Therapy Journal

Developing an at‐home dementia rehabilitation intervention: An iterative qualitative codesign study

Clare Stephenson, Sophia Hadjimichael, Kasia Bail, Diane Gibson, Stephen Isbel, Michelle Bennett, Nathan M. D'Cunha

Abstract Introduction There is limited availability of community‐based rehabilitation for people with dementia. This study explored stakeholder perspectives to inform the design of an occupational therapy‐led at‐home dementia rehabilitation programme. Methods Four co‐design workshops were conducted over 6 months with 16 participants, including people with dementia, care partners and health‐care professionals. Transcribed workshop discussions underwent iterative thematic analysis to inform the final intervention com …

02.09.2026journal-article

Journal of Acute Care Physical Therapy

Physical Therapist Practice in the Emergency Department: From Innovation to an Emerging Standard of Care

Stacie Fruth, Kelsie Clark, Kevin E. Brueilly

ABSTRACT Purpose/Introduction: U.S. Emergency departments (EDs) face challenges related to patient volume, wait times, and resource utilization. Although physical therapists (PTs) are increasingly integrated into ED settings, the characteristics of this specialty practice remain widely unknown. Existing literature demonstrates that PT involvement in EDs can positively impact wait times, length of stay, imaging use, hospital admissions, and patient satisfaction. However, how PTs are currently utilized within U.S. ED …

02.09.2026journal-article

PLOS One

Technology-Assisted Rehabilitation Gym for at-home Training (TARGeT) for stroke survivors: A study protocol for evaluating feasibility, safety, usability, clinical benefit, and costs

Simone Kager, Hsiao-Ju Cheng, Christopher Wee Keong Kuah, Tengiz Samkharadze, Hao Ping Lin, Chwee Yin Ng, Tegan Kate Plunkett, Sam Lee, Niranjana Devi, Filzah Sumartono, Isaac Lu, Ananda Sidarta, Eloise Lie, Irina Hungerbuehler, Daryl Chong, Anoop Kumar Sinha, Chi Onn Tang, David Matchar, Giada Devittori, Christoph Kanzler, Asif Hussain, Bernardo Noronha, Muhammad Azhar, Gabriel Aguirre-Ollinger, Roger Gassert, Karen Sui Geok Chua, Nicole Wenderoth, Olivier Lambercy

Stroke is a leading cause of long-term disability, with more than half of survivors experiencing persistent upper limb impairments. Despite clear evidence that high-dose, repetitive, task-specific training is essential for motor recovery, many stroke survivors do not receive a sufficiently high therapy dose – particularly in the outpatient phase. Limited therapist availability, high care costs, and travel burdens remain key barriers to accessing rehabilitation training. While technology-assisted rehabilitation has …

02.09.2026journal-article

NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy

National Institute of Environmental Health Sciences (NIEHS) Worker Education and Training Program (WETP) Response to the World Trade Center (WTC) Disaster: Initial WETP Grantee Response and Preliminary Assessment of Training Needs

Donald Elisburg, John Moran

Executive Summary: The attack on the World Trade Center on September 11, 2001 and the subsequent magnitude of the destruction and loss of life at the World Trade Center Complex (WTC) created an emergency response, rescue, and recovery effort of enormous proportions. New York City, State, and many Federal disaster response organizations, in addition to thousands of volunteers and other support organizations, quickly responded, including the National Institute of Environmental Health Sciences (NIEHS)-Worker Education …

02.09.2026journal-article

International Journal of Molecular Sciences

Real-World Outcomes of Fusion-Directed Targeted Therapy in Advanced Non-Small Cell Lung Cancer Harboring Actionable Gene Fusions

Faure Delgado Leon, Suset Almuinas de Armas, Melanie Molina, Eric G. Morales, Maria Fernandez-Gomez, Luis Estuardo Raez

Actionable ALK, ROS1, RET, NTRK, and NRG1 fusions define biologically distinct subsets of advanced non-small cell lung cancer (NSCLC), yet real-world data across these rare populations remain limited. We retrospectively evaluated patients with advanced NSCLC treated at Memorial Healthcare System who received genotype-matched fusion-directed therapy; the first fusion-directed agent defined the index treatment, and survival was measured from its initiation. Progression was determined from radiographic reports and tre …

02.09.2026journal-article

Scientific Reports

Dual-modality modeling for depression detection using speech signals

Na Wang, Jing Li, Weijia Zhang, Raja Kamil, Ian Renner, Syed Abdul Rahman Al-Haddad, Normala Ibrahim, Zhen Zhao

Abstract Depression is a leading contributor to the global burden of disease and a significant barrier to both personal well-being and societal development. Yet, it remains underdiagnosed, primarily due to social stigma and limited access to clinical resources. This study proposes a dual-modality framework for automated depression detection using speech signals, capturing both what individuals say (text) and how they say it (vocal cues) from speech recordings. The method integrates contextual embeddings and acousti …

02.09.2026journal-article

Africa Journal of Nursing and Midwifery

OA unpaid#21699 Pregnant Women’s Knowledge and Awareness of Sexually Transmitted Infections in Selected Public Health Facilities in the North West Province

Simônd Croesér Steenekamp, Khumoetsile Daphney Shopo

Background: South Africa is considered to have a high prevalence of sexually transmitted infections (STIs), which continue to impose a major public health burden. Untreated STIs can lead to long-term, irreversible and potentially fatal outcomes in pregnant women. This study aimed to assess the knowledge and awareness of pregnant women in the North West Province (NWP) regarding STIs. Methods: A quantitative cross-sectional descriptive design was applied to reach the objective. Five health facilities were selected wi …

02.09.2026journal-article

Africa Journal of Nursing and Midwifery

Factors Associated with Substance Use among Nurses and Midwives in Referral Hospitals in Botswana

Gaonyadiwe Lubinda, Onalenna Tsima, Mosidi Mokotedi

Substance use among nurses and midwives is escalating globally. Nurses and midwives face numerous workplace challenges and resort to substance use to cope. The specific factors associated with substance use in this population group remain underexplored. The purpose of this study was to explore factors associated with substance use among nurses and midwives in referral hospitals. A qualitative, descriptive research design was employed. Based on saturation, a semi-structured interview guide was used to collect data f …

02.09.2026journal-article

Blood Cancer Discovery

Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP

Qingyu Luo, Karley S. Whalen, Xiaowei Wu, Amanda L. Fortune, Jacqueline S. Garcia, Kate Marinchev, Lin Zhang, Weiye Qian, Evangeline G. Raulston, Yabing Nan, Christopher A.G. Booth, Kezhi Yan, David E. Root, John G. Doench, Andrew A. Lane

Abstract Acute myeloid leukemia (AML) is prone to relapse driven by therapy-persistent residual cells. To discover specific vulnerabilities in this population, we performed genome-wide CRISPR interference screens in leukemia cells treated with multiple agents. KHSRP was the top hit, whose depletion sensitized AML cells to therapy and substantially prolonged survival in treated AML-bearing mice. Analysis of in vivo residual disease after venetoclax/azacitidine treatment identified downregulation of the vitamin C and …

02.09.2026journal-article

Africa Journal of Nursing and Midwifery

Nurses’ Perspectives on Spirituality and Spiritual Care for Critically Ill Patients in Intensive Care Units: A Systematic Review of Qualitative Studies

Nour Dhiaeyah Binti Supuan Zaki, Soh Kim Lam, Ahmad Aizuddin Bin Md Rami

Background: Nurses’ competencies in spiritual care are increasingly in demand in intensive care (ICU) units, yet their perspectives, preparedness and challenges in delivering such care remain unclear.Aim: This qualitative systematic review explores ICU nurses’ understanding and perspectives of spiritual care for critically ill patients.Method/Study Design: Following the Enhancing Transparency in Reporting the Synthesis of Qualitative Research guidelines, eligible qualitative and mixed-method studies (2016–2025) wer …

02.09.2026journal-article

Journal of Speech, Language, and Hearing Research

The Differential Impact of Sleep-Dependent Consolidation in Speech Perceptual Learning: A Systematic Review

Xinming Zhou, F. Sayako Earle

Purpose: Sleep plays a critical role in speech-sound learning. However, owing to methodological heterogeneity and inconsistent findings, the mechanisms by which sleep consolidates speech sounds are poorly understood. This review synthesizes evidence on sleep-dependent speech-sound consolidation to identify consistent behavioral patterns. Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, we searched five major databases supplemented by reference list screening …

02.09.2026journal-article

Langenbeck's Archives of Surgery

Clinical and paraclinical parameters association to complications after abdominal closure following vacuum-assisted closure therapy in secondary peritonitis: A retrospective cohort study

Ask Vang, Pooya Rajabaleyan, Sören Möller, Sardar Khalaf, Uffe Tange Holst, Pedja Cuk, Benjamin Schnack Brandt Rasmussen, Thomas Strøm, Mark Bremholm Ellebaek

Abstract Purpose To evaluate clinical and paraclinical parameters at the time of abdominal closure following vacuum-assisted closure (VAC) therapy in patients with secondary peritonitis, and to identify associations to postoperative complications. Methods This retrospective multicenter cohort study included patients with secondary peritonitis from the small intestine, colon, or rectum who underwent emergency laparotomy and VAC therapy at six hospitals in southern Denmark between 2010 and 2019. Clinical status and l …

02.09.2026journal-article

Dietetics

Mitochondria-Targeted Nutraceuticals as Metabolic Adjuncts to Physical Rehabilitation in Older Adults with Sarcopenia or Frailty: A Narrative Review

Alessio Turco, Lorenzo Lippi, Francesca Uberti, Alessandro de Sire, Marco Invernizzi

Age-related skeletal muscle wasting, clinically expressed as sarcopenia and frailty, significantly limits the efficacy of physical rehabilitation due to an underlying cellular bioenergetic decline, mitochondrial dysfunction, and chronic inflammaging. This narrative review synthesizes current physiological and clinical evidence evaluating mitochondria- targeted nutraceuticals as targeted metabolic adjuvants to physical exercise in older adults. Comprehensive literature searches were executed across PubMed, Web of Sc …

02.09.2026journal-article

ANZ Journal of Surgery

Prioritising Psychological Prehabilitation Interventions for Cancer Surgery: An International Delphi Study

Nicholas Hirst, Jesse Gates, Haryana M. Dhillon, Ilona Juraskova, Kate Alexander, Jack Reeves, Zirong Bai, Michael J. Solomon, Kate McBride, Leani Souza Máximo Pereira, Ana Paula Drummond Lage, Daniel Steffens, Global (P)rehabilitation Initiative

ABSTRACT Background Preoperative mental wellbeing is an important determinant of postoperative recovery, yet psychological care is frequently overlooked within multidisciplinary prehabilitation programmes. When included, psychological interventions are fragmented and inconsistently delivered. This study aimed to establish international multidisciplinary consensus on preferred psychological prehabilitation interventions for patients undergoing urogenital, thoracic or gastrointestinal cancer surgery, and to describe …

02.09.2026journal-article

Australian Occupational Therapy Journal

Acceptability and feasibility of the Home Support Needs Assessment in a forensic mental health service: An initial study

Aleksandra Westcott, Lorrae Mynard, Gabrielle Pitt, Susan Darzins

Abstract Introduction Identifying and addressing the support needs of forensic mental health patients in daily life occupations is critical yet complex due to the health comorbidities and environmental restrictions impacting their participation. Occupational therapists support forensic patient recovery by facilitating their performance in daily life occupations required at home and in the community. Standardised assessments of daily living are important for guiding interventions. The Home Support Needs Assessment ( …

02.09.2026journal-article

Journal of Rehabilitation Medicine

Home-based digital exercise versus hospital physiotherapy for plantar fasciitis: a propensity-score-matched retrospective cohort study with dual-perspective cost-utility evaluation

Wenbo Xu, Lufeng Yao, Haigang Wang, Chenqin Xu, Pinpin He, Yi Zhang, Jiasong Pan, Shengdi Lu, Lei Huang

Objective: To compare the clinical effectiveness and cost-effectiveness of a 12-week home-based digital exercise programme with 12-week hospital-supervised physiotherapy for plantar fasciitis in routine Chinese tertiary-hospital care. Design: Single-centre retrospective cohort study with 1:2 propensity-score matching on 13 baseline covariates. Subjects/Patients: 587 adults with a clinician-confirmed diagnosis of plantar fasciitis treated in 2022–2024 were matched. Methods: The primary outcome was first-step morning …

02.09.2026journal-article

Head & Neck

Bone‐Anchored Implant Survival in Oncologic Facial Prosthetic Rehabilitation

Oliver Blanshard, Sarah Jones, Peter M. Clarke, Jonathan M. Bernstein

ABSTRACT Background Published survival rates for bone‐anchored craniofacial implants exceed 85%, but derive largely from mixed populations. Whether these apply to head and neck oncologic surgery remains uncertain. Methods Retrospective survival analysis of implants placed for prosthetic rehabilitation following extirpative surgery at a UK center (2005–2024). Results Survival among 184 implants in 51 patients was 94%, 60% and 46% at 1, 3 and 5 years (median 4.1 years, 95% CI 3.0–6.3). 77% of patients received radiat …

02.09.2026journal-article

British Journal of Midwifery

A descriptive content analysis of TikTok videos for postnatal perineal wound care education

Sonia O'Kelly, Declan Patton, Chanel Watson

Background/Aims TikTok is a rapidly growing social media platform, with large numbers of patients accessing it instead of attending in-person consultations. This review aimed to explore the information available on TikTok regarding patient education for postnatal perineal wound care. Methods A video search using the phrase ‘postnatal perineal care’ was performed followed by a hashtag function search in November 2024. The videos were analysed by video metrics, content purpose and video content. Results The top two o …

02.09.2026journal-article

The Journal of Forensic Practice

Development and evaluation of a psychological rehabilitation programme for Thai women imprisoned for drug-related offences

Chanakida Thummanond, Tippayaporn Pavavimol, Dusida Tinmala

Purpose This study aimed to develop and evaluate Kor–Rang–Sang–Jai, a psychological training programme designed to support rehabilitation readiness among Thai female inmates convicted of drug-related offences. Design/methodology/approach The research was conducted in two phases. Phase 1 focused on programme development through documentary review, synthesis of psychological and educational foundations, activity design, and expert validation. The resulting programme, Kor–Rang–Sang–Jai, comprised 30 activities deliver …

02.09.2026journal-article

Gut Pathogens

Comparative effects of vonoprazan-based and esomeprazole-based dual therapy on Helicobacter pylori eradication and short-term gut microbiota changes

Yi Liu, Xuetian Qian, Jiayue Yao, Chunming Fei, Zhenyu Zhang, Zongdan Jiang

Abstract Objective This study aimed to compare the Helicobacter pylori (H. pylori) eradication efficacy, safety, patient compliance, and short-term effects on the gut microbiota of vonoprazan-based potassium-competitive acid blocker (P-CAB) dual therapy and esomeprazole-based proton pump inhibitor (PPI) dual therapy. Methods A total of 110 H. pylori-positive patients were enrolled and non-randomly assigned to the P-CAB group ( n = 50, vonoprazan 20 mg bid + amoxicillin 750 mg qid) or the PPI group ( n = 60, esomepr …

02.09.2026journal-article

Complications

Turning Failure into Success: Prosthetic Rehabilitation After Surgical Setback in Gingival Squamous Cell Carcinoma

Davide Meneghetti, Claudia Manera, Giampaolo Drago, Guido Bissolotti, Marny Fedrigo, Christian Bacci

Oral squamous cell carcinoma (OSCC) is a common malignancy that can develop from precancerous conditions such as oral lichen planus (OLP). This case report describes the clinical management and complication reporting of a patient with OLP who developed an exophytic lesion on the anterior maxillary gingiva, diagnosed as well-differentiated OSCC (cT1N0M0). Surgical treatment included anterior maxillectomy and reconstruction using an iliac crest bone graft housed in a customized CAD-CAM titanium mesh, covered by a fac …

02.09.2026journal-article

AIDS

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

Miłosz Parczewski, Maurizio Zazzi, Kaja Mielczak, Micha Böhm, Olaf Degen, Rolf Kaiser, Francesca Incardona, Anders Sönnerborg, Maarten A.A. van de Klundert

Objective: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (BIC). Methods: The virological outcome of first-line DTG or BIC-containing antiretroviral therapy (ART) was assessed in 261 people with HIV-1A6 (PWH-1A6) and 1042 people with HIV-1B (PWH-1B) starting treatment between January 2014 and May 20 …

02.09.2026journal-article

Radiation

Theranostics in Pancreatic Neuroendocrine Neoplasms: From Molecular Imaging to Personalized Radionuclide Therapy

Takehiro Okabayashi, Ryo Inada, Motoyasu Tabuchi, Rika Yoshimatsu, Yuji Negoro, Akihito Nishioka

Pancreatic neuroendocrine neoplasms (PanNENs) are a heterogeneous group of tumors characterized by variable biological behavior and frequent overexpression of somatostatin receptors, making them ideal candidates for theranostic approaches. Over the past two decades, advances in molecular imaging and peptide receptor radionuclide therapy (PRRT) have fundamentally transformed the diagnosis and management of advanced PanNENs, establishing nuclear medicine as a central component of precision oncology. This review provi …