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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

MRI radiomics-based predictive modeling for risk stratification and prognostication in oral tongue carcinoma

Nivedita Chakrabarty, Swapnil U. Rane, Umesh Sherkhane, Sourabh More, Nitin Shetty, Sarbani Ghosh Laskar, Arjun Singh, Vanita Noronha, Kumar Prabhash, Pankaj Chaturvedi

Introduction This study aims to predict recurrence-free survival (RFS) and overall survival (OS), to stratify risk using radiomics, radiology semantic, clinical, and pathology models—individually and in combination—derived from pre-treatment magnetic resonance imaging (MRI), post-operative histopathology, age, and adjuvant therapy details in oral tongue squamous cell carcinoma (OTSCC), and to correlate National Comprehensive Cancer Network (NCCN) low + intermediate- and high-risk groups with the risk stratification …

03.09.2026journal-article

Frontiers in Neurology

Interpretable machine learning–based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke

Yuanfang Zhou, Xiaoxia Li, Guokuan Feng, Chuanhang Lin, Bao Liao

Background Despite high recanalization rates after endovascular treatment (EVT) for acute ischemic stroke due to large vessel occlusion (AIS-LVO), 15%−20% of patients still die within 90 days. Existing prognostic models predominantly target functional disability rather than mortality, and rarely incorporate calibration, clinical utility, or interpretability. We aimed to develop and internally validate interpretable machine learning (ML) models for dynamic post-EVT in-hospital prediction of 90-day all-cause mortalit …

03.09.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Use of subconjunctival cyclosporine implants for treatment of feline eosinophilic keratoconjunctivitis: a case report

Lynn Willems, Jordan Kay Roberts

Case summary A 5-year-old neutered male domestic shorthair cat was presented for evaluation of chronic bilateral eosinophilic keratoconjunctivitis (EK). The patient had a history of recurrent corneal plaques and conjunctivitis that were initially managed with systemic and topical immunosuppressive therapy. Long-term disease control was limited by poor tolerance of topical ophthalmic medications, resulting in inconsistent treatment and repeated disease recurrence affecting both eyes. Over several years the cat was t …

03.09.2026journal-article

Monaldi Archives for Chest Disease

Treatment outcomes and factors associated with unfavorable outcomes among drug-resistant tuberculosis patients treated with a bedaquiline-based oral regimen

Oki Nugraha Putra, Julaeha Julaeha, Nurhayati Nurhayati, Telly Purnamasari, Nurul Damayanti, Dewi Ramdani, Ahmad Erlan, Paisal Paisal, Rini Sasanti Handayani, Nur Indah

The treatment success rate for drug-resistant tuberculosis (DR-TB) in Indonesia remains below the national target. Identifying factors associated with unfavorable treatment outcomes is essential to inform more targeted interventions. This retrospective study analyzed medical records of patients with DR-TB who received treatment at Surabaya Haji Hospital between 2020 and 2024. Demographic, clinical, behavioral, and treatment-related variables were evaluated in relation to unfavorable treatment outcomes, defined as a …

03.09.2026journal-article

Cancer Drug Resistance

Resistance to third-generation EGFR TKIs - what can be expected from the fourth-generation?

Wolfram C. M. Dempke, Klaus Fenchel, Loretta Sullivan, Martin Reck

Tyrosine kinase inhibitors (TKIs) have significantly changed the treatment of non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations, and osimertinib is now established as first-line therapy for NSCLCs. Combination therapies (e.g., osimertininb plus chemotherapy; lazertinib plus amivantamab) have been shown to improve median progression-free survival (mPFS) and median overall survival (mOS) relative to monotherapy. However, due to several resistance mechanisms, patients expe …

03.09.2026journal-article

Discover Oncology

Identification of FN1 and TIMP1 as macrophage-associated programmed cell death-related prognostic markers in glioblastoma via integrated bulk and single-cell RNA sequencing

Feng Li, Caifeng Wang, Zhesen Tian, Chunmei Liu, Yufeng Zhang, Jiankai Yang, Xiaojing Chang

Abstract Background Glioblastoma (GBM) is the most common primary intracranial malignancy in adults, characterized by poor survival and high mortality. Emerging evidence suggests that macrophage-associated programmed cell death (MacPCD) plays a critical role in GBM pathogenesis. However, the underlying mechanisms remain poorly understood. This study aimed to identify MacPCD-related prognostic genes in GBM and explore their functional roles. Methods Transcriptomic data from the GSE68848 dataset were integrated with …

03.09.2026journal-article

Frontiers in Oncology

A deep transfer learning radiomics nomogram using chest CT for differentiating anterior mediastinal cysts from low-grade thymomas

Li Zhao, Dengwang Zhao, Tong Zhou, Xueqing Sui, Pei Nie, Chongfeng Duan

Objectives The objective of this study was to develop a nomogram by integrating clinical features, radiomics predictive results, and deep transfer learning (DTL) predictive results to differentiate between anterior mediastinal cysts (AMCs) and low-grade thymomas. Methods The training set included 149 cases of AMCs and low-grade thymomas, whereas the test set included 49 cases of AMCs and low-grade thymomas. Contrast-enhanced chest CT images were used for analysis. A deep transfer learning radiomics (DTLR) nomogram …

03.09.2026journal-article

Frontiers in Oncology

Surgical resection with postoperative stereotactic radiosurgery versus stereotactic radiosurgery alone for large (>3 cm) multiple brain metastases: a propensity score-matched analysis

Xufei Guo, Kuanyu Wang, Shiqi Shi, Li’ao Wang, Yutong Zhao, Dan Xiao, Wang Jia, Shibin Sun, Deling Li

Purpose While surgery plus stereotactic radiosurgery (SRS) is established for solitary brain metastases, its role in multiple brain metastases (MBM) remains unclear. This study compared survival in MBM patients undergoing resection of the largest tumor plus postoperative SRS versus SRS alone. Methods This retrospective study included adults with 2–4 MBM, a dominant lesion >3 cm, and Karnofsky Performance Status ≥70. We compared patients undergoing resection of the dominant lesion plus SRS against those receiving …

03.09.2026journal-article

Frontiers in Oncology

Ultrasound radiomics for preoperative evaluation of Ki-67 proliferation index in papillary thyroid carcinoma

Hui Shi, Jiayi Qiu, YuLu Wu, Ying Zhang, HengQi Zhang, YunYun Liu, YiTong Li, JiaHui Ni, ChongKe Zhao, HuiXiong Xu, LiPing Sun, LeHang Guo, YiFeng Zhang

Purpose To explore the predictive value of radiomics features, ultrasound (US), and gene mutation status based on interpretable random forest (RF) models for predicting high Ki-67 expression in papillary thyroid carcinoma (PTC). Methods This retrospective analysis included 627 patients with surgically confirmed PTC who underwent testing for BRAF V600E and TERT promoter mutations, as well as immunohistochemical assessment of Ki-67 expression from December 2015 to June 2023. The eligible patients were randomly divide …

03.09.2026journal-article

Frontiers in Endocrinology

The circadian–melatonin axis in breast cancer metastasis: molecular mechanisms, organ-specific metastatic niches, and therapeutic opportunities

Ching-Hsiang Wang, Kian-Hwee Chong, Ching-Feng Cheng, Yao-Jen Chang, Kuo-Wang Tsai

Breast cancer metastasis remains the leading cause of disease-related mortality despite major advances in systemic therapy. Increasing evidence indicates that the circadian–melatonin axis may influence metastatic progression by coordinating endocrine signaling, metabolism, immune responses, and tumor cell plasticity. In this review, we summarize current epidemiological, mechanistic, and translational evidence linking circadian disruption and melatonin to breast cancer metastasis. We discuss how core circadian clock …

03.09.2026journal-article

Journal of Clinical Medicine

The Association of SARIFA with Poor Prognosis and Aggressive Tumor Phenotypes in Cancers: A Meta-Analysis

Jiaqi Lao, Guangwei Tian, Lin Guan

Background: SARIFA (Stroma Areactive Invasion Front Areas) is an emerging histopathological biomarker defined by direct tumor–adipocyte contact at the invasive front. Preliminary studies suggest its association with poor prognosis, but evidence remains fragmented across cancer types. This meta-analysis aims to systematically evaluate the prognostic value of SARIFA for overall survival (OS) and its correlation with aggressive tumor phenotypes. Methods: Following PRISMA guidelines, we searched PubMed, Embase, Web of …

03.09.2026journal-article

Ege Tıp Dergisi

Preoperative halp score in gastric cancer patients undergoing upfront gastrectomy: Clinicopathological associations and survival outcomes

Erkan Güler, Melih Taşkın

Aim: This study aimed to evaluate the association of the preoperative hemoglobin–albumin–lymphocyte–platelet (HALP) score with clinicopathological characteristics and overall survival in gastric cancer patients undergoing primary curative-intent gastrectomy.Materials and Methods: This retrospective single-center study included patients who underwent gastrectomy for histologically confirmed gastric adenocarcinoma between January 2010 and December 2025. Of 149 initially evaluated patients, 12 who received neoadjuvant …

03.09.2026journal-article

Journal of Neuro and Oncology Research

Autoimmune-Associated Lymphocytic Central Nervous System (CNS) Vasculitis Presenting as a Tumefactive Cerebral Infarct Mimicking Multicentric Glioma

Pankaj Patil, Shelja Jha, Sujata Prabhu, Akash Prabhu, Arshiet Dhamnaskar, Santosh Prabhu

Purpose: Central nervous system vasculitis may rarely present as a tumor-like lesion with enhancement, edema, mass effect and multifocality, closely mimicking glioma. We report an uncommon case of autoimmune-associated lymphocytic CNS vasculitis presenting as a tumefactive cerebral infarct radiologically mimicking multicentric glioma. Methodology: Clinical history, neurological examination, preoperative imaging, operative findings, histopathology, immunohistochemistry, postoperative course and blood-based autoimmun …

03.09.2026journal-article

Journal of Cancer Survivorship

Survivorship care for melanoma patients: a scoping review

Madlen Hörold, Sasha Schutkowski, Karl-Philipp Drewitz, Sebastian Haferkamp, Jochen Schmitt, Friedegund Meier, Maike Bergmann, Benjamin Küster, Marlon Pape, Christian Apfelbacher

Abstract Purpose Despite significant advances in melanoma treatment, many survivors continue to experience long-term effects of disease and therapy. Various survivorship care programs have been developed in recent years, but these differ in terms of their scope, content, and delivery. The aim of this scoping review was to summarize existing literature on melanoma survivorship care. Methods The search strategy was developed using the PCC (Population, Concept, Context) framework for scoping reviews. We conducted syst …

03.09.2026journal-article

Acta Neurochirurgica

Risk stratification and treatment outcomes after surgical treatment of 0unruptured intracranial aneurysms: a single-center retrospective review

Jessica Y Jung, Alex Kostynskyy, Ronit Agid, Pascal Mosimann, Timo Krings, Hugo Andrade Barazarte, Michael Tymianski, Ivan Radovanovic

Abstract Purpose Management of unruptured intracranial aneurysms (UIAs) requires weighing rupture risk against treatment risk. As endovascular techniques have evolved, microsurgical intervention has become increasingly concentrated at high-volume centers and reserved for complex cases, potentially representing a higher-risk endeavor than reflected in earlier series. A contemporary evaluation of patient and aneurysm-related features associated with surgical risk and postoperative outcomes is needed. Methods We condu …

03.09.2026journal-article

Healthcare

The Correlation of Psychological Symptoms, Quality of Life and Resilience in Patients with Recurrent Non-Melanoma Skin Cancer

Goran Šimić, Tomislav Sušac, Josip Lesko, Ana Dugandžić Šimić, Vedran Markotić, Dragan Babić

Recurrent non-melanoma skin cancer (NMSC) may be accompanied by cosmetic, functional, and emotional consequences. Aims: To examine associations among psychological symptoms, quality of life, resilience, and religiosity and to compare psychological outcomes between patients treated once and patients with recurrent facial NMSC. Methods: This cross-sectional study included 160 patients after surgery for facial NMSC (63 treated once and 97 with recurrent disease). Data were collected with a sociodemographic questionnai …

03.09.2026journal-article

Frontiers in Surgery

Posterior minimally invasive percutaneous short-segment fixation combined with mini-open anterior L5 corpectomy for metastatic tumor: a case report and literature review

Talgat Kerimbayev, Meirzhan Oshayev, Murat Arlanbekov, Aizhan Baltabay, Serik Akshulakov

Background Metastatic tumors of the lumbar spine are a common complication of advanced malignancies. They often present with severe pain, neurological deficits, and spinal instability. Surgical removal of L5 vertebral body metastases is challenging due to the complex anatomy and biomechanical characteristics of the lumbosacral junction. Corpectomy using a combined approach is a common surgical strategy for achieving pain relief, adequate tumor resection, spinal cord and root decompression, and spinal stabilization. …

03.09.2026journal-article

Frontiers in Surgery

Adult Wilms tumor revealed after radical nephrectomy for a renal mass initially suspected to be clear-cell renal cell carcinoma: a case report

Kunxiang Wang, Jin Long, Cheng Pan, Yaowen Zhang, Peng Ren, Xiaojun Wan

Introduction Nephroblastoma is the most common malignant renal neoplasm in children but remains exceptionally rare in adults. Compared with pediatric cases, adult Wilms tumor (AWT) often presents greater diagnostic challenges and is associated with larger tumor volumes and more advanced disease at diagnosis, contributing to poorer prognoses. Consequently, adults with Wilms tumor have significantly worse outcomes than pediatric patients. Because of the limited number of reported cases, no standardized management alg …

03.09.2026journal-article

Frontiers in Immunology

T-cell redirecting therapies in lung cancer - a comprehensive analysis of clinical trials

Jiahe Zhao, Ayrton Bangolo, Lili Zhang, Martin Gutierrez, Miguel Gonzalez-Velez

Lung cancer remains the leading cause of cancer-related mortality worldwide, and despite the transformative impact of immune checkpoint inhibitors (ICIs), primary and acquired resistance, limited efficacy in immune-cold tumors such as extensive-stage small cell lung cancer (ES-SCLC), and the absence of durable responses in a substantial proportion of patients define the unmet need that T cell-redirected therapies aim to address. These strategies engage, engineer, and deliver cytotoxic T cells against tumor cells in …

03.09.2026journal-article

Frontiers in Pharmacology

Exposure–response relationship of sintilimab in advanced gastric cancer: insights from time-dependent pharmacokinetics and biomarker integration for precision immunotherapy

Jingyi Zhou, Jingzhi Wang, Lin Liu

Background Immune checkpoint inhibitors (ICIs), particularly programmed cell death protein-1 (PD-1) antibodies, exhibit substantial interpatient variability in both efficacy and immune-related adverse events (irAEs). Conventional exposure-response (E-R) paradigms are often insufficient to capture these dynamics, limiting their utility for individualized immunotherapy. Objective To critically re-evaluate the E-R relationship of Sintilimab in advanced gastric cancer (AGC) by integrating pharmacokinetics (PK), host- a …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

Cancer Research

CDState Resolves Malignant Cell Heterogeneity from Bulk Tumor RNA Sequencing Data

Agnieszka Kraft, Josephine Yates, Florian Barkmann, Valentina Boeva

Abstract Intratumor transcriptional heterogeneity (ITTH), defined as the coexistence of diverse cell states within a single tumor, complicates cancer treatment and contributes to variable therapeutic responses. Although single-cell RNA sequencing (scRNA-seq) can resolve this complexity, its cost and technical demands limit large-scale use. Bulk RNA-seq provides a scalable alternative but requires computational methods to deconvolve bulk transcriptomes into distinct cell states. Existing supervised approaches rely o …

03.09.2026journal-article

BMC Anesthesiology

Comparative influence of opioid-free versus opioid-containing anesthetic techniques upon Th1/Th2 balance during laparoscopic colorectal cancer procedures: a randomized controlled trial

Li Hong, Yunyan Wang, Zhi Cheng, Hengfei Luan, Zhibin Zhao

Abstract Background Surgical resection is central to colorectal cancer management, but surgery and anesthesia can induce perioperative immunosuppression. Opioids, a mainstay of perioperative analgesia, may impair cellular immunity, including disruption of Th1/Th2 immune equilibrium. This randomized controlled trial evaluated whether opioid-free anesthesia (OFA) better preserves perioperative immune function than opioid-based anesthesia. Methods Sixty patients scheduled for elective laparoscopic colorectal cancer re …

03.09.2026journal-article

Frontiers in Surgery

Case Report: Management of tibial fracture nonunion: a case study of treatment failure and lessons learned

Chaoshuai Wang, Chen Wang

Concept of “mechanical–biological balance” is fundamental to successful fracture healing; disruption of either component can lead to healing failure. Fractures of the middle and distal tibia are commonly encountered in clinical practice, particularly when associated with comminution. Managing fracture nonunion requires a comprehensive assessment of infection status, skeletal alignment, bone defect, implant stability, and host biological characteristics. This case report aims to explore the etiological factors of ti …