Difference in Effectiveness Between The Use of Captopril and Amlodipine on Lowering Blood Pressure in Primary Hypertension Cases at The Piyungan Health Center

Vollständiger Abstract

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Background: Hypertension is one of the leading causes of morbidity worldwide, with sufferers estimated to reach 1.5 billion and mortality reaching 9.4 million individuals by 2025. In Indonesia, hypertension prevalence reached 34.1% (Riskesdas, 2018), with the Special Region of Yogyakarta (DIY) recording 11.01%. Captopril and amlodipine are commonly used first-line antihypertensive drugs. This study aims to determine the difference in effectiveness between captopril and amlodipine in reducing blood pressure among patients with primary hypertension. Method: This retrospective, before-after (pre-post) comparative study used secondary data from the medical records of 151 outpatients at the Piyungan Health Center (31 receiving captopril and 120 receiving amlodipine). Blood pressure was assessed before and after drug administration. Based on data normality and homogeneity testing, the Kruskal-Wallis test was used to analyze systolic blood pressure and the One-Way ANOVA test to analyze diastolic blood pressure. Results: Both tests showed significant results (p=0.000; p