10.3389/fpsyg.2012.00132

Vollständiger Abstract

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<h4>Objective</h4>The ageing population poses emerging challenges to HIV prevention, particularly in regions with high proportions of older adults. We conducted a cross-sectional study of 513 newly diagnosed HIV-infected individuals in Shaodong City, Hunan Province, China, between 2021 and 2025, with a focus on individuals aged ≥60 years.<h4>Methods</h4>HIV-1 pol sequences were amplified, sequenced, and analyzed for subtype distribution and transmitted drug resistance (TDR). Molecular transmission networks were constructed using a 0.5% genetic distance threshold, and clusters were classified as large (≥10 nodes), medium (5-9 nodes), or small (<5 nodes).<h4>Results</h4>CRF85_BC was the predominant subtype (32.55%), and a total of 37 transmission clusters were identified, with the two largest clusters comprising 99 and 19 nodes, respectively. High-risk nodes, defined as those with a transmission network score (TNS) ≥ 0.75 and degree ≥4, were primarily older male farmers engaged in heterosexual commercial sex. The overall TDR prevalence was 10.53%, with NNRTI resistance predominating, and K103N being the most frequent mutation.<h4>Conclusion</h4>Our findings indicate that HIV transmission among older adults exhibits substantial clustering, largely driven by commercial sexual activity, and highlight the importance of molecular network analysis for identifying high-risk individuals and guiding targeted prevention interventions. Continuous surveillance of TDR within active clusters is critical for optimizing antiretroviral therapy strategies and mitigating onward transmission.

Abstract: PubMed · Datensatz