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Case Report: Near-complete resolution of nail psoriasis with upadacitinib in a pediatric patient

Yulin Huang, Sijian Wen

Frontiers in Immunology · 2026

Vollständiger Abstract

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Nail psoriasis (NP) is refractory in children, causing punctate pits, onycholysis, subungual hyperkeratosis and discoloration, impairing quality of life. We report a 14-year-old boy with 4-year NP, all fingernails involved with no cutaneous lesion, and unresponsive to traditional therapy. After 20-week oral upadacitinib, all nail lesions achieved near-complete resolution with only minimal residual nail changes, and no treatment-related adverse events. This suggests that upadacitinib demonstrates favorable efficacy and safety for pediatric refractory NP, large-scale prospective clinical investigation are warranted to validate our findings.

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Publikationsdaten

Autor:innen
Yulin Huang, Sijian Wen
Quelle
Frontiers in Immunology
Publikation
2026-01-01
Band / Ausgabe
Nicht angegeben
Seiten
Nicht angegeben
ISSN / ISBN
1664-3224
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Zitierfähiger Nachweis

Yulin Huang, Sijian Wen (2026). Case Report: Near-complete resolution of nail psoriasis with upadacitinib in a pediatric patient. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2026.1941127
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