JAVMA News

Vollständiger Abstract

Worum geht es in dieser Arbeit?

<h4>Objective</h4>To summarize owner-reported recurrence of clinical signs consistent with thoracolumbar intervertebral disk herniation in dogs treated by intradiskal injection of chondroitinase ABC (ChABC) and to compare recurrence rate versus routine surgical management.<h4>Methods</h4>This pragmatic retrospective, time-matched cohort comparison study included 2 groups of dogs that recovered independent locomotion (> 50 unsupported steps) following treatment between October 2022 and March 2025 for acute nonambulatory paraparesis or paraplegia, assumed or proven to be caused by intervertebral disk herniation, with (1) 1.25-U ChABC injections into 4 consecutive intervertebral disks targeted on the basis of neurologic examination or (2) routine decompressive surgery following cross-sectional imaging. Recurrent clinical signs were reported retrospectively to investigators.<h4>Results</h4>The study population consisted of 47 ChABC-treated dogs and 79 surgical cases with similar demographics. Fenestration number in the surgery group was variable (7 dogs had 0 fenestrations, 32 dogs had 1, 17 dogs had 2, 20 dogs had 3, and 3 dogs had an unknown number). Recurrence occurred in 24 of 79 surgical dogs (30%) compared to 6 of 47 ChABC-treated dogs (13%). Univariable Poisson regression demonstrated a significantly lower recurrence rate in the ChABC group (incidence rate ratio [IRR], 0.38; 95% CI, 0.17 to 0.87) and in older dogs (IRR, 0.81; 95% CI, 0.70 to 0.93). The optimized multivariable model included both these variables and suggested that ChABC injections were associated with an adjusted recurrence incidence rate reduction of approximately 70%.<h4>Conclusions</h4>Multidisk injection of ChABC was associated with a reduced rate of owner-reported recurrence of clinical signs suggestive of intervertebral disk herniation compared to surgery.<h4>Clinical relevance</h4>Intradiskal injection of ChABC may be an effective prophylactic against intervertebral disk herniation.

Abstract: PubMed · Datensatz