ASSOCIATION OF VITAMIN D SUPPLEMENTATION AND ANTIDIABETIC THERAPY WITH MUSCLE STRENGTH AND FATIGUE SEVERITY IN ADULTS WITH LONG-STANDING TYPE 2 DIABETES MELLITUS

Vollständiger Abstract

Worum geht es in dieser Arbeit?

Objectives: The objectives of the study are to examine the associations of current Vitamin D supplementation and antidiabetic treatment pattern with muscle strength, physical performance, fatigue severity, and glycemic control among adults with long-standing type 2 diabetes mellitus. Methods: This hospital-based cross-sectional study included 288 adults with diabetes duration of at least 5 years. Current Vitamin D supplementation, antidiabetic regimen, serum 25-hydroxyvitamin D, glycated hemoglobin, handgrip strength, five-chair stand time, and Fatigue Severity Scale score were assessed at a single visit. Multivariable linear and logistic regression used pre-specified clinical covariates, and Holm correction was applied within predefined families of multiple comparisons. Results: Vitamin D supplement users had higher serum 25-hydroxyvitamin D concentrations than non-users (30.6±6.1 vs. 18.6±5.4 ng/mL; Holm-adjusted p