Systemic Sclerosis and Abortion: Determining Factors and Clinical Significance in a Multicenter Study

Vollständiger Abstract

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Objective The aim of this work was to identify disease-related factors associated with a history of spontaneous abortion in adult female patients with systemic sclerosis (SSc), and to further analyze the distinguishing features of SSc patients with recurrent versus single abortion episodes. Materials and Methods This multicenter case-control study was extracted from a nationwide SSc cohort of 1,080 patients. Ninety-one female adult SSc patients (8.4%) with a history of spontaneous abortion before 20 completed weeks of gestation were compared with 91 age-matched female SSc patients without a history of spontaneous abortion. Clinical characteristics, comorbidities, organ involvement, medications, and laboratory parameters were analyzed. Results Patients with spontaneous abortion had significantly longer disease duration (6.4±4.7 vs . 4.6±4.2 years; p =0.007), a higher prevalence of comorbidities (29.7% vs . 15.4%; p =0.03), more frequent telangiectasia (28.6% vs . 12.1%; p =0.009) and a higher frequency of mycophenolate mofetil use (29.7% vs . 15.4%; p =0.03) compared with patients without a history of spontaneous abortion. Recurrent spontaneous abortion occurred in 30 patients (33.0%). Compared with those with a single spontaneous abortion, patients with recurrent spontaneous abortion had significantly higher frequencies of Raynaud’s phenomenon ( p