Mental disorders in uncomplicated pregnancy: a systematic review

Vollständiger Abstract

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Objective. This systematic review aims to provide a thorough analysis of existing Russian scientific literature regarding mental disorders in uncomplicated pregnancies. It focuses on the prevalence, clinical features, risk factors, and their impact on perinatal outcomes. Material and methods. Following the PRISMA-ScR protocol, a systematic review was performed. A comprehensive search was conducted in the eLibrary, Russian State Library, National Electronic Library, and PubMed databases utilizing relevant keywords. Only original Russian empirical studies published before 2026 were included. Of 345 publications identified, 55 met the established criteria after duplicates were removed and compliance assessed. Results. The sample sizes of the selected studies varied from 50 to 1340 participants. Notably, only 9 studies (16%) strictly excluded cases of complicated pregnancies, whereas 2 studies included women with pre-existing mental disorders. Longitudinal psychometric studies were scarce, with only 2 publications fitting this description. A continuous clinical and psychopathological assessment revealed a prevalence rate of 26.9% for nosologically verified mental disorders in uncomplicated pregnancies. The most prevalent disorders identified were neurotic, stress-related, somatoform disorders, personality disorders, and affective disorders. Furthermore, psychometric screening indicated that the prevalence of clinically significant anxiety symptoms in pregnant women reached 65.8%, while depressive symptoms were noted in 54%. Key risk factors identified include a history of psychiatric and obstetric disorders, insufficient partner support, younger maternal age, advanced reproductive age, and adverse social conditions. Conclusions. The occurrence of mental disorders during uncomplicated pregnancies represents a significant yet inadequately researched issue In Russia. The existing evidence predominantly depends on psychometric data, revealing a significant lack of clinical and psychopathological research. The frequent exclusion of women with a history of mental disorders from study samples contributes to an underrepresentation of chronic mental health pathologies. To address this gap, longitudinal clinical studies and the establishment of interdisciplinary guidelines for early diagnosis are needed.