Vollständiger Abstract
Worum geht es in dieser Arbeit?
This study identifies endothelial hypoxia-inducible factor-1α (HIF-1α) as a critical determinant of neonatal lung response to hyperoxia. Using an inducible endothelial-specific Hif-1α knockout model, we demonstrate that loss of endothelial Hif-1α exacerbates hyperoxia-induced impairments in pulmonary vascular development and alveolarization, key pathological features of bronchopulmonary dysplasia.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Han-Pi Chang, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Krithika Lingappan
- Quelle
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1040-0605, 1522-1504
- Zitationen
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Zitierfähiger Nachweis
Han-Pi Chang, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Krithika Lingappan (2026). The role of endothelial HIF-1 α in vascular and alveolar development in a neonatal murine model of bronchopulmonary dysplasia. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00073.2026