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Well-being differences and changes in people with somatic and psychiatric disorders or multimorbidities: modelling COVID-19 as a global natural experiment of stress vulnerability

Till J Adam, Trevor Thompson, Fabiola H Peroz, Jan P Heisig, Paul Gellert, Enrique Alonso-Perez, Lara Bister, Lau Caspar Thygesen, Philippe Conus, Roland von Känel, Soraya Seedat, Denisa Manková, Daniel Guinart, Eduard Vieta, Mark J Millan, Diego De Leo, Michael Berk, Jess Fiedorowicz, Lin Yang, Jari Tiihonen, Harald Aschauer, Monika Schlögelhofer, Jane E Hamilton, Marco Solmi, Christoph U Correll

BMJ Mental Health · 2026

Vollständiger Abstract

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Background Somatic and psychiatric illnesses and multimorbidities increase stress-vulnerability and decrease well-being. Objective We aimed to identify high-risk disorder profiles for lower well-being and well-being decline under stress, modelling COVID-19 as a natural experiment. Methods The global Collaborative Outcomes Study on Health and Functioning during Infection Times survey assessed the World Health Organization-Five Well-being Index (WHO-5) (0–100) retrospectively pre-pandemic and intra-pandemically. Mixed-effects models, controlling for demographic/pandemic-related covariates, examined coprimary outcomes: total pre-pandemic WHO-5 and pre-to-intra-pandemic change (estimating β); pre-pandemic WHO-5

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Autor:innen
Till J Adam, Trevor Thompson, Fabiola H Peroz, Jan P Heisig, Paul Gellert, Enrique Alonso-Perez, Lara Bister, Lau Caspar Thygesen, Philippe Conus, Roland von Känel, Soraya Seedat, Denisa Manková, Daniel Guinart, Eduard Vieta, Mark J Millan, Diego De Leo, Michael Berk, Jess Fiedorowicz, Lin Yang, Jari Tiihonen, Harald Aschauer, Monika Schlögelhofer, Jane E Hamilton, Marco Solmi, Christoph U Correll
Quelle
BMJ Mental Health
Publikation
2026-01-01
Band / Ausgabe
Nicht angegeben
Seiten
Nicht angegeben
ISSN / ISBN
2755-9734
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Till J Adam, Trevor Thompson, Fabiola H Peroz, Jan P Heisig, Paul Gellert, Enrique Alonso-Perez, Lara Bister, Lau Caspar Thygesen, Philippe Conus, Roland von Känel, Soraya Seedat, Denisa Manková, Daniel Guinart, Eduard Vieta, Mark J Millan, Diego De Leo, Michael Berk, Jess Fiedorowicz, Lin Yang, Jari Tiihonen, Harald Aschauer, Monika Schlögelhofer, Jane E Hamilton, Marco Solmi, Christoph U Correll (2026). Well-being differences and changes in people with somatic and psychiatric disorders or multimorbidities: modelling COVID-19 as a global natural experiment of stress vulnerability. BMJ Mental Health. https://doi.org/10.1136/bmjment-2026-302777
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