Comprehensive Genomic Profiling Timeliness Beyond Laboratory Turnaround Time: A Patient‐Facing Pathway Analysis

Vollständiger Abstract

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ABSTRACT Aim We evaluated the timeliness of the patient‐facing comprehensive genomic profiling (CGP) pathway by separating laboratory and post‐laboratory intervals within an expert panel‐mediated process, using direct disclosure of results to patients as the endpoint. Methods This single‐center retrospective study included adult CGP test episodes performed under government‐funded cancer genomic medicine at a Japanese university hospital between October 2019 and November 2025. The primary outcome was patient‐centered turnaround time (TAT), defined as the interval from informed consent to direct disclosure of the CGP result to the patient. Laboratory TAT and pathway intervals were summarized descriptively, and laboratory TAT was compared across assays. Results Among 882 CGP test episodes, median laboratory TAT was 14 days (interquartile range [IQR], 12–16) among 871 evaluable episodes. Among 828 evaluable episodes, median patient‐centered TAT was 41 days (IQR 35–45). The laboratory analysis retained observed long intervals, including a maximum of 72 days; no episode was excluded solely because laboratory TAT exceeded 56 days. These findings indicate that laboratory TAT was only one component of the longer consent‐to‐disclosure pathway. Conclusion In this routine‐care CGP pathway, patient‐facing timeliness depended on the full process from consent to direct patient disclosure. Patient‐centered TAT should be monitored alongside laboratory TAT as a care–delivery measure.