Vollständiger Abstract
Worum geht es in dieser Arbeit?
Introduction: Increasing chronological age drives dynamic changes in platelet functionality, bringing unique biologic challenges to the injured older adult. While platelets play an indispensable role in injury response, the impact of age on platelet dynamics after injury remains elusive. We examine the associations of age and platelet dynamics for injured patients not on antiplatelet therapy, hypothesizing that aging is associated with decreases in platelet count and function in injured patients. Methods: We performed a secondary analysis of injured patients from a prospective observational study of coagulation and inflammation (2010-2024). Patients taking anticoagulants, antiplatelets, and/or with isolated traumatic brain injury were excluded. Univariable and multivariable associations of age and platelet count and function profiles (impedance aggregometry and viscoelastic testing) at presentation and up to seven days post-injury were analyzed. Platelet profiles, thromboembolic events, and mortality relationships were analyzed by stratifying age to
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Genna Beattie, Bellal A. Joseph, Brenda Nunez-Garcia, Suzanna Chak, Celine Chou, Isabel Arango, Seif Elmankabadi, Karl Zoghbi, Kim Bardillon, Michelle Conte, Cedric M.V. Bainton, Joseph Cuschieri, Mitchell J. Cohen, Rachael A. Callcut, Alexander T. Fields, Lucy Z. Kornblith
- Quelle
- Shock
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1540-0514, 1073-2322
- Zitationen
- 0 laut Crossref
- Referenzen
- 0 hinterlegt
Zitieren
Zitierfähiger Nachweis
Genna Beattie, Bellal A. Joseph, Brenda Nunez-Garcia, Suzanna Chak, Celine Chou, Isabel Arango, Seif Elmankabadi, Karl Zoghbi, Kim Bardillon, Michelle Conte, Cedric M.V. Bainton, Joseph Cuschieri, Mitchell J. Cohen, Rachael A. Callcut, Alexander T. Fields, Lucy Z. Kornblith (2026). Aging at the Cellular Level: An Exploratory Analysis of the Effect of Age on Platelet Dynamics in Injured Patients. Shock. https://doi.org/10.1097/shk.0000000000002934