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Weight trajectories in virally suppressed people with HIV compared to matched people without HIV, and predictors of weight gain: a 3-year cohort study from the US TRIO Healthcare Network

Graeme Moyle, Janna Radtchenko, Joshua Gruber, Megan Dunbar, Cal Cohen, Neia Prata Menezes, Isobel McEwen, Paul Sax, Grace McComsey, Karam Mounzer, Moti Ramgopal, Steven Santiago, Paul Benson, Monica Mercon, Richard Elion

JAIDS Journal of Acquired Immune Deficiency Syndromes · 2026

Vollständiger Abstract

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Background: Weight gain in people with HIV (PWH) has generated concern regarding metabolic consequences of antiretroviral therapy (ART). It is unclear whether weight gain differs between virally suppressed (VS) PWH and people without HIV (PWoH) when accounting for key characteristics, or which clinical and demographic factors drive weight gain in VS PWH. Methods: This retrospective observational cohort study utilized electronic records from 12 US federally qualified health centers (January 2015-August 2023). Part A employed multi-stage propensity score matching (4:1 ratio) to compare 3-year weight trajectories adjusting for demographics, comorbidities, and medications. Part B used classification and regression trees (CART), logistic regression to identify predictors of weight gain (≥10% gain with BMI shift or baseline obesity) vs minimal gain (>0% to

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Autor:innen
Graeme Moyle, Janna Radtchenko, Joshua Gruber, Megan Dunbar, Cal Cohen, Neia Prata Menezes, Isobel McEwen, Paul Sax, Grace McComsey, Karam Mounzer, Moti Ramgopal, Steven Santiago, Paul Benson, Monica Mercon, Richard Elion
Quelle
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publikation
2026-01-01
Band / Ausgabe
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ISSN / ISBN
1525-4135, 1944-7884
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Graeme Moyle, Janna Radtchenko, Joshua Gruber, Megan Dunbar, Cal Cohen, Neia Prata Menezes, Isobel McEwen, Paul Sax, Grace McComsey, Karam Mounzer, Moti Ramgopal, Steven Santiago, Paul Benson, Monica Mercon, Richard Elion (2026). Weight trajectories in virally suppressed people with HIV compared to matched people without HIV, and predictors of weight gain: a 3-year cohort study from the US TRIO Healthcare Network. JAIDS Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/qai.0000000000003932
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