Vollständiger Abstract
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Abstract REM Sleep Behaviour Disorder (RBD) is a hallmark of the prodromal phase of α-synucleinopathies. We aimed to describe the prevalence of probable RBD and to assess its associations with demographics, cognition, and location in a large sample of older adults in Luxembourg, as a first step toward identifying individuals with RBD symptoms for future prodromal-marker assessment. In 2021, residents of Luxembourg aged 55–75 were invited to complete an online survey including the RBD Screening Questionnaire (RBDSQ); with a threshold of ≥ 7 defining screen-positive probable RBD (sppRBD). Screen-positive participants underwent a telephone interview, and those confirmed were categorised as telephone-assessed probable RBD (pRBD). Bayesian spatial mapping assessed the geographical distribution of pRBD, and logistic regression identified determinants of sppRBD and pRBD. Among 15,915 participants (54% male; median age 62 [IQR 58–67]), 12.4% had sppRBD. The telephone interview confirmed only 34.8% of these as pRBD, yielding a projected prevalence of 4.3%. Self-reported cognitive impairment, male sex, and Portuguese as questionnaire language were associated with pRBD, which showed heterogeneous geographical distribution. Online questionnaires may yield false positives, potentially reflecting e-health literacy issues; therefore, a confirmation step is essential. This analysis identifies individuals with RBD symptoms warranting further prodromal-marker assessment, a candidate group for, rather than a validated instance of, an at-risk-for-α-synucleinopathy cohort.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Gloria A. Aguayo, Eduardo Rosales Jubal, Gilles Van Cutsem, Anna Schritz, Olena Tsurkalenko, Tainá M. Marques, Deborah McIntyre, Clarissa P. C. Gomes, Rajesh Rawal, Soumyabrata Ghosh, Kirsten Roomp, Claire Pauly, Magali Perquin, Lukas Pavelka, Venkata Satagopam, Michel Vaillant, Rejko Krüger, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Muhammad Ali, Wim Ammerlann, Giuseppe Arena, Rudi Balling, Michele Bassis, Roxane Batutu, Katy Beaumont, Regina Becker, Camille Bellora, Guy Berchem, Daniela Berg, Alexandre Bisdorff, Ibrahim Boussaad, David Bouvier, Kathrin Brockmann, Jessica Calmes, Lorieza Castillo, Gessica Contesotto, Nancy De Bremaeker, Nico Diederich
- Quelle
- Scientific Reports
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 2045-2322
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Zitierfähiger Nachweis
Gloria A. Aguayo, Eduardo Rosales Jubal, Gilles Van Cutsem, Anna Schritz, Olena Tsurkalenko, Tainá M. Marques, Deborah McIntyre, Clarissa P. C. Gomes, Rajesh Rawal, Soumyabrata Ghosh, Kirsten Roomp, Claire Pauly, Magali Perquin, Lukas Pavelka, Venkata Satagopam, Michel Vaillant, Rejko Krüger, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Muhammad Ali, Wim Ammerlann, Giuseppe Arena, Rudi Balling, Michele Bassis, Roxane Batutu, Katy Beaumont, Regina Becker, Camille Bellora, Guy Berchem, Daniela Berg, Alexandre Bisdorff, Ibrahim Boussaad, David Bouvier, Kathrin Brockmann, Jessica Calmes, Lorieza Castillo, Gessica Contesotto, Nancy De Bremaeker, Nico Diederich (2026). Screening Luxembourg's older general population for probable REM sleep behaviour disorder with a nationwide online survey. Scientific Reports. https://doi.org/10.1038/s41598-026-67511-z
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