Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

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Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related outcomes in the murine brain. METHODS Female mice were exposed to 32 ppm Pb or control water during gestation and lactation. Offspring were aged out to 3 weeks or 18 months. We measured Aβ in the 18‐month cortex and performed untargeted metabolomics in plasma and cortex at 3 weeks and 18 months of age. RESULTS Diffuse Aβ and Aβ‐positive cells were significantly elevated with Pb exposure. Pb‐associated metabolites were enriched for those implicated in oxidative stress, inflammation, and lipid metabolism. DISCUSSION Pb was associated with molecular and metabolic features of dementia. Important biochemical classes provide insights into possible mechanisms by which developmental Pb exposure may contribute to dementia risk.