Wissenschaftliches Journal · EZB
Wiley (John Wiley & Sons)
Inhaltsverzeichnis
11.09.2026
Jing Ma, Shanshan Zhang, Xiaokang Deng, Cheng Qi, Haifeng Dong, Zhou Liu, Si Meng, Tiantian KongScaffold‐free tissue engineering aims to recapitulate native cellular organization, yet constructing structurally stable tissue architectures beyond planar geometries remains challenging. Here, we show that hydrogel lumen confinement, created through aqueous‐in‐aqueous embedded b …
05.09.2026
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona FarbehiSilk fibroin, a natural protein polymer derived from the silkworm Bombyx mori , has emerged as a versatile biomaterial in regenerative medicine. Its mechanical strength, cytocompatibility, slow biodegradability, and tunable properties have positioned silk as a promising candidate …
04.09.2026
Anton Roshchupkin, Benjamin Chacon, Gulnaz Gahramanova, Inna Chorna, Zhanna Klishchova, Anastasia Konieva, Ilya Yanko, Andrii Liutyi, Milena Yalyzhko, Ivan Baginskiy, Veronika Zahorodna, Júlio Sílvio de Sousa Bueno Filho, Erfan Rezvani Ghomi, Igor Panko, Tetiana Shapochka, Oksana Sulaieva, Oleksandr Solodovnyk, Lucia Gemma Delogu, Oleksiy Gogotsi, Laura Fusco, Sergiy Kyrylenko, Yury Gogotsi, Maksym PogorielovNiobium‐based MXenes exhibitefficient near‐infrared (NIR) absorption but remain underexplored for in vivo cancer therapy. In this study, we investigated Nb 4 C 3 T x MXene as an NIR‐II photothermal therapy (PTT) sensitizer for melanoma. Both in vitro and in vivo experiments were …
01.09.2026
Cristina Oldani, Alice Caldiroli, Federica Barzaghi, Nina Bono, Gabriele Candiani, Stefania Adele RiboldiCurrent in vitro degradation methodologies for absorbable medical devices often employ nonphysiological enzyme concentrations or bacterial proteases, limiting their predictive value for in vivo performance. Here, a framework for assessing protein‐based device degradation is devel …
27.08.2026
Xumin Huang, Liwei Liu, Jiayuan Zhu, Xinghao Hu, Changkui Fu, Yao Wang, Lining Arnold Ju, Thomas P. Davis, Andriansjah Rukmana, Shaohua Ma, Zheng Zhang, Ruirui QiaoMagnetic resonance (MR) imaging is a widely used noninvasive diagnostic technique, in which contrast‐enhanced imaging accounts for nearly half of all clinical MRI examinations. Although gadolinium‐based contrast agents are extensively employed, their potential safety concerns hav …
25.08.2026
Ao Shen, Liwen Zhang, Helen Forgham, Jiayuan Zhu, Xumin Huang, Changkui Fu, Ibrahim Javed, Thomas P. Davis, Ruirui QiaoAlzheimer's disease (AD) is a progressive neurodegenerative disorder marked by the deposition of amyloid‐beta (Aβ) plaques in the brain. Early diagnosis and effective targeted therapies remain critical challenges in managing AD. Herein, we present the design and development of no …
11.08.2026
Mohammad Mohammadi, Eva Tomaskovic‐Crook, Peter C. Innis, Jeremy M. CrookWireless piezoelectric stimulation can be used for minimally invasive and targeted neuromodulation, including augmenting neural tissue induction in vitro and regeneration in vivo. Here, we describe piezoelectric nanocomposite hydrogel (PZ‐gel)‐based neural tissues comprising algi …
31.07.2026
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling WangSmall extracellular vesicles (sEVs) are nanosized membrane‐bound particles facilitating intercellular communication in the nervous system. Although previous studies investigated sEVs released from various neural cell lines, a comprehensive comparison among various immortalized ne …
28.07.2026
Jeesu Moon, Min Seo Kim, Jae‐Seung LeeThe clinical translation of advanced nanomedicines and next‐generation wearables is frequently bottlenecked by material instability and interfacial incompatibility. Deep eutectic systems (DESs), historically categorized merely as green organic solvents and closely related to ioni …
21.07.2026
Daniel De Maria, Amy Gelmi, Peter C. Sherrell, Stefan Di Medio, Nhiem Tran, Kate FoxDental implants are a common and effective solution for tooth loss. However, achieving consistent soft tissue integration (STI) remains a significant challenge, affecting their long‐term performance. A robust soft tissue seal around implants is essential for protecting against ba …
16.07.2026 · 1 Zitationen
Nazila V. Jafari, Jennifer L. RohnAnimal models have been used to investigate urinary tract catheters, but small animals do not accurately recapitulate human bladder physiology nor support different types of catheters. Recent advances in three‐dimensional models mimicking tissue microenvironments have improved ou …
14.07.2026
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. WeiImmunotherapeutics have rapidly evolved as an advanced cancer therapeutic strategy, offering superior survival compared to conventional treatments. This strategy catalyzed both generalized and precision‐based cancer therapeutics. Nevertheless, the immunosuppressive tumor microenv …
12.07.2026
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. HerrmannDirect selective removal of disease‐etiologic factors from blood is a potentially lifesaving intervention in multiple medical conditions (including sepsis). Magnetic separation‐based blood purification represents a selective therapeutic strategy addressing limitations of conventi …
10.06.2026
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. SteinmetzIn high‐income countries, 60%–70% of oropharyngeal squamous cell carcinomas (OPSCCs) are attributable to human papillomavirus (HPV). Immunotherapy is the current second‐line treatment for advanced or metastatic cases of HPV + OPSCC; however, drug resistance, tumor heterogeneity, …
31.08.2026
10.1002/anbr.7015328.05.2026
Aaqil Rifai, Ayushi Priyam, Ahmed Rashed, Gebreselassie Addisu Tilaye, Kamal Poudel, Aaron G. Schultz, Richard J. WilliamsNanodiamonds (NDs) have garnered significant attention due to their unique potential, including displaying excellent bacterial resistance and favourable interactions with mammalian cells. Here, we show multifaceted biocompatibility of NDs both in vitro and in vivo. The NDs show e …
23.05.2026
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi GuDysfunctional endothelium with chronic inflammation represents an early stage in the development of atherosclerotic plaques. Nanomedicines capable of targeting activated endothelium and resolving inflammation have great potential for atherosclerosis treatment. In this work, we de …
05.05.2026
Kimia Tavakoli Dehaghi, Sepideh Khoee, Shima Tavakoli, Oommen P. VargheseIn this study, the fabrication of multi‐stimuli‐responsive bowl‐shaped Janus nanomotors integrating platinum nanoparticles coated with cross‐linked Fe 3 O 4 @P(BA‐co‐IA) and functionalized with polypyrrole on the surface of iron oxide nanoparticles for potential targeted drug del …
01.05.2026
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander BekeschusCold physical gas plasma generates various reactive oxygen and nitrogen species and has emerged as potential anticancer treatment. However, its effects on and into tumor tissue are poorly understood. Using three gas plasma‐treated tumor models (in ovo Panc1 pancreas carcinoma tis …
28.04.2026
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. ChristmanAcute myocardial infarction (AMI) causes cardiac tissue damage and creates a transient leaky vasculature, which is an attractive target for intravascular therapeutics. Nanomaterials have the potential to deliver therapeutics to the injured heart, yet the influence of particle siz …
24.04.2026
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo DecuzziOsteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, inflammation, and dysregulated chondrocyte metabolism. Increasing evidence suggests that epigenetic modifications, particularly alterations in DNA hydroxymethylation regulated by ten‐eleve …
21.04.2026
Shuyu Zhang, Anne E. StaplesBiomaterials, generally defined as materials that interact with biological systems, are ubiquitous in the field of biomedical engineering. Biomaterials can undergo natural aging, in which changes in material properties occur in near‐ambient or near‐physiological environments with …
02.08.2026
10.1002/anbr.7014623.04.2026 · 1 Zitationen
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐TrilloThis study investigated targeted antimicrobial delivery through enzyme‐responsive polyelectrolyte complex (PIC) nanoparticles of peptides and antimicrobials. Nanoparticles released chlorhexidine upon enzymatic activation by human leukocyte elastase ( HLE ), mimicking conditions p …
15.04.2026 · 1 Zitationen
Frank Fei, Yogambha Ramaswamy, Young Jung NoInjectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation. Despite substantial progress, clinical translation remains limited by persistent challenges, …
15.04.2026 · 1 Zitationen
Gloria Kemunto, Kristen DellingerExtracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are play an important role in intercellular communication and hold promise for drug delivery systems (DDSs). Their unique morphology and customizable attributes position EVs as innovative pl …
14.04.2026
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe LerouxReceptor‐targeting ligands can improve the specificity and cellular uptake of drugs and gene delivery systems. However, there is currently a lack of rapid, high‐throughput assays to identify ligands that efficiently induce endocytosis. To address this gap, we developed a flow cyt …
31.03.2026 · 2 Zitationen
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. AdairGene editing using CRISPR systems has gained traction for its potential to treat various diseases, but delivery remains a major challenge. We have previously reported an entirely synthetic gold nanoparticle formulation which can safely and effectively deliver multiple different C …
24.03.2026
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. DaleTendon injuries affect millions each year, yet effective repair remains limited by the tissue's avascular nature and complex mechanobiology. An anisotropic electrospun scaffold functionalized with GDF‐7‐loaded mesoporous silica nanoparticles (MSNs) is developed to address these c …
09.07.2026
10.1002/anbr.7013724.03.2026
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der LindeCold medical gas plasma promotes hemostasis through platelet activation, yet the underlying molecular and functional mechanisms remain incompletely understood. Here, we investigated gas plasma‐induced platelet activation in human whole blood using flow cytometry, transcriptomic p …
23.03.2026 · 1 Zitationen
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐EscotoPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5‐year survival rate below 13% and limited treatment options due to rapid metastasis and pronounced chemoresistance. Gemcitabine (Gem) remains a first‐line chemotherapy agent; however, its clinical …
17.03.2026
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi ChenThis review synthesises current evidence on selenium nanoparticles (SeNPs) as a therapeutic platform for wound repair. Owing to their multifunctional bioactivity, SeNPs can concurrently deliver antimicrobial, anti‐inflammatory, and proregenerative effects through diverse mechanis …
07.03.2026 · 1 Zitationen
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. HindNeutrophils are crucial players in the fight against infections. Unfortunately, dysregulated neutrophil function contributes to the pathogenesis of diseases, including cancer, fibrosis, and atherosclerosis, that leave those afflicted vulnerable to severe infections. Many of these …
22.02.2026
Mingjie Yang, Ying Zhi Cheong, Chenglong Xu, Sanje Mahasivam, Xudong Cai, Vipul Bansal, Sharath Sriram, Ganganath Perera, Madhu BhaskaranTumor necrosis factor‐ α (TNF‐ α ) has emerged as a critical biomarker for insulin resistance and diabetic complications, offering an alternative avenue for diabetes management beyond conventional glucose monitoring. Current methods for detecting TNF‐ α are constrained by their c …
01.06.2026
10.1002/anbr.7013507.03.2026
Wensheng Lin, Binbin Cui, Xuecheng He, Suo Tu, Shilei Dai, Xinran Zhang, Ivo Pang, Xiaonan Chen, Jixiang Zhu, Shiming ZhangContinuous glucose monitoring (CGM) is a commercially available biochemical sensor for diabetes management. A growing trend in this field is the transition from long needles to microneedles to reduce pain and avoid bleeding. A promising strategy for microneedle‐based CGM involves …
24.02.2026
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. KanoPancreatic ductal adenocarcinoma (PDAC) features a fibrotic tumor microenvironment that impedes drug delivery and significantly limits the successful clinical application of nanomedicines. Targeting signaling in pancreatic stellate cells (PSCs), which drive fibrosis via excessive …
24.02.2026 · 1 Zitationen
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. HarleyGlioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, with limited survival outcomes due to tumor recurrence, mainly driven by GBM cell invasion and therapy resistance. Although temozolomide (TMZ) remains the standard‐of‐care chemotherapeut …
22.02.2026 · 1 Zitationen
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni VozziCurrent surgical approaches to reconstruct functional organization of tendon/ligament‐to‐bone interface, namely enthesis, often fail, highlighting the need for bioinspired tissue engineering strategies that replicate its native complexity. This study investigates the cellular res …
22.02.2026
Sally Kortam, Zufu Lu, Iman Roohani, Ghazal Shineh, Leila Mamizadeh Janghour, Huu Nguyen Ngoc, Pooria Lesani, Behnam Akhavan, Hala ZreiqatOsteosarcoma (OS) is a primary malignant bone tumor often treated by surgical resection and systemic chemotherapy, which can cause severe side effects and nonspecific drug distribution. Localized drug delivery via bone scaffolds offers a promising alternative but faces limitation …
13.02.2026 · 1 Zitationen
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp UhlThe growing concerns regarding the immunogenicity of polyethylene glycol (PEG) have prompted the search for alternative excipients that can prolong circulation in parenteral drug delivery. Archaeal lipids, known for their structural stability and unique membrane properties, repre …
27.04.2026
10.1002/anbr.7013025.03.2026 · 2 Zitationen
Davide V. Verdolino, David M. Warde, Helen A. Thomason, Kimberly A. Mace, Sarah H. CartmellChronic wounds pose a global challenge by increasing patient morbidity and healthcare costs. Collagen‐based dressings, a key category for treating recalcitrant wounds, offer multiple advantages; however, comparative data on their benefits are sparse. A synthetic non‐bioactive con …
05.03.2026 · 1 Zitationen
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun WangEndometriosis (EM) results in pelvic adhesions and chronic inflammation, which significantly reduce embryo implantation and the clinical pregnancy rates of in vitro fertilization (IVF), affecting 190 million women worldwide. Traditional hormonal and surgical treatments alter ovar …
26.02.2026
Roberta Fabbri, Karima Jeneh Perry, Emanuela Saracino, Chiara Lazzarini, Anna Mariano, Diletta Spennato, Maria Grazia Mola, Maria Grazia Raucci, Alessandro Kovtun, Marianna Barbalinardo, Giorgia Conte, Denis Gentili, Marco Caprini, Vincenzo Palermo, Roberto Zamboni, Luigi Ambrosio, Wolfgang Losert, Andrea Candini, Grazia Paola Nicchia, Raj K. Gupta, Valentina Benfenati, Shashi P. KarnaAstrocyte ion channels, water channels, and calcium signaling play vital roles in maintaining brain homeostasis, coordinating neural network activity, supporting cognitive functions, and mediating neurovascular coupling. Disruptions in astrocyte dynamics are causally linked to gl …
19.02.2026 · 2 Zitationen
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun YangNeurologic disorders place a significant burden on both patients and society due to their high disability rate and difficulty in curing, yet traditional treatments have limitations in efficacy and obvious side effects. Neuromodulation techniques have been used in clinical practic …
16.02.2026
Cristina Oldani, Nina Bono, Alice Caldiroli, Stefania Adele Riboldi, Gabriele CandianiDespite significant advances in biomedical research, translating academic innovations into commercial medical devices (MDs) remains a formidable challenge. Many academic teams achieve promising results but lack the regulatory and strategic expertise required for successful commer …
16.02.2026
Victoria Schemenz, Maximilian Rummler, Alexander van Tol, Isabela Vitienes, Tobias Thiele, Markus A. Hartmann, Manfred Burghammer, Peter Fratzl, Richard Weinkamer, Bettina M. Willie, Wolfgang WagermaierThis article investigates the heterogeneity of bone nanostructure in 26‐week‐old C57BL/6J mice, focusing on tibial mid‐shaft cross‐sections. We aimed to investigate the relationship between calcium content, mineral nanostructure, lacuno‐canalicular network (LCN) organization, and …
04.04.2026
10.1002/anbr.7012318.02.2026 · 1 Zitationen
Jann Harberts, Malte Siegmund, Emma Wollesen, Caroline Viola, Kim Krieg, Ole Pless, Roey Elnathan, Robert Zierold, Robert H. Blick, Nicolas H. VoelckerNeuronal differentiation of human induced pluripotent stem cells (hiPSCs) is a cornerstone for advancing neuroscience research and therapeutic applications. However, conventional differentiation protocols are commonly resource‐intensive, technically complex, and overall time‐cons …
18.02.2026
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao ZhangRadiotherapy and chemotherapy are widely employed in cancer treatment but frequently induce intestinal toxicity, which significantly compromises patients’ quality of life and limits therapeutic efficacy. Polyphenols, a diverse class of natural compounds with broad biological acti …
15.02.2026 · 2 Zitationen
Louis Bourlon, Carole Fournier, Antoine Hoang, Christine Charrat, Alban Lepetitcolin, Jessica Morlieras, Fabrice Navarro, Patrice N. MarcheInfluenza vaccines targeting hemagglutinin require annual updates due to viral variability, limiting protection against pandemic strains. The conserved matrix protein 2 ectodomain (M2e) peptide offers cross‐strain immunity but suffers from low immunogenicity. Here, M2e peptides a …
26.01.2026 · 1 Zitationen
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok SonAutoimmune diseases (AIDs) affect millions of individuals worldwide, impacting ≈10% of the population, with women being more susceptible to them than men. AIDs include multiple sclerosis (MS), type 1 diabetes (T1D), and rheumatoid arthritis (RA), which arise when the immune syste …
20.01.2026 · 1 Zitationen
Dhananjay V. Deshmukh, Emilie Vuille‐dit‐Bille, Saumitra Joshi, Nicola Gerber, Christine Fux, Annina Eichenberger, Epifania Bono, Markus Rimann, Sarah Heub, Daniel Migliozzi, Stephanie Boder‐Pasche, Gilles Weder, Jurg Dual, Mark W. TibbittMicrotissues (such as organoids or spheroids) are useful to model healthy or diseased human tissues and organs, with application in drug testing, tissue engineering, and personalized medicine. To characterize their morphology and phenotype, microtissues are often monitored using …
16.01.2026 · 1 Zitationen
Jintao Yang, Jie Chen, Yunmiao Ma, Qingwei Zhou, Yu Kong, Yingxiang Chen, Junjie Chi, Haihua HuAcne vulgaris is a prevalent chronic inflammatory skin disease, for which topical pharmacotherapy remains challenging due to the skin barrier and complex pathological mechanisms. In recent years, micro/nanocarrier‐based dermal delivery systems have emerged as novel strategies to …
16.01.2026
Shaza Karaman, Mei ElGindi, Jeremy TeoTertiary lymphoid structures (TLSs) are inducible, ectopic aggregates that mirror the architecture and immunological functions of secondary lymphoid organs, arising in nonlymphoid tissues during chronic inflammation, infection, autoimmunity, and cancer. Their ability to orchestra …
04.01.2026
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver LielegMicroRNAs (miRNAs) are critical regulators of gene expression, and their dysregulated expression has been implicated in the context of various diseases. Despite their therapeutic potential, the physicochemical instability and off‐target effects of miRNA‐targeting therapeutics pos …
03.03.2026
10.1002/anbr.7011603.03.2026
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang21.01.2026 · 2 Zitationen
Xiaozhuo Wu, Bingyun Li, Malcolm XingThe concept of utilizing micro/nanorobot (MNR) for drug delivery in vivo was raised decades ago, and numerous prototypes have been created ever since. Other than the application of delivering drugs, nanorobots are also widely researched for noninvasive surgery, cell stimulation, …
