Wissenschaftliches Journal · EZB
Wiley (John Wiley & Sons)
Inhaltsverzeichnis
05.09.2026
Evandro Fei Fang, Hilde Nilsen, Morten Scheibye‐Knudsen, Vilhelm A. Bohr, Lin KangABSTRACT Understanding the molecular mechanisms of aging guides the development of prevention, intervention, and treatment strategies to reduce the incidence of common age‐associated diseases. Over the past decades, the proposed key features (hallmarks) of aging cells have direct …
02.09.2026
Qi Pan, Lixin GuoABSTRACT Obesity in older adults has become a prominent public health issue. Owing to age‐related physiological changes and multimorbidity, obesity in this population is associated with complex clinical manifestations and markedly increased difficulty in management. Based on this …
02.09.2026
Christiano Barbosa da Silva, Isiyara Taverna Pimenta, Rosane Harter Griep, Arlinda Barbosa Moreno, Isabela Judith Martins Bensenor, Sandhi Maria Barreto, Maria Inês Schmidt, Anissa Daliry, Maria de Jesus Mendes da FonsecaABSTRACT Objectives Hair cortisol has been increasingly used as an important biomarker of chronic stress, as it reflects prolonged systemic exposure to cortisol over time. Such exposure has been associated with alterations in body composition; however, the associations with sarco …
02.09.2026
Shun‐yu Yao, Miao‐qiao Du, Lan‐xin Lin, Xu‐hui Kang, Dai‐yi Jiang, Yong PengABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative disorders globally and have long been classified as clinically and pathologically distinct syndromes. AD is defined by amyloid‐β (Aβ) plaques and tau‐positive neurofibrilla …
24.08.2026
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang ChenABSTRACT Aortic dissection (AD) is a life‐threatening vascular disorder characterized by separation of the layers of the aortic wall, primarily triggered by an intimal tear or an intramural hemorrhage. Age is a well‐recognized and critical risk factor for AD. Epidemiological evid …
20.08.2026
Ali Vahedi, Maria Eriksdotter, Hege Ihle‐Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar FureABSTRACT Objectives Older persons are often referred to emergency departments due to acute functional decline, that is, reduced activities of daily living occurring in the days before hospitalization, frequently driven by acute medical conditions. We aimed to describe frailty in …
20.08.2026
Xiaoming Wang, Cuntai ZhangABSTRACT Dysregulation of the renin‐angiotensin‐aldosterone system (RAAS) constitutes a pivotal factor in the onset and progression of various geriatric diseases, including cardiovascular diseases, diabetes, and chronic kidney disease (CKD), all closely linked to adverse cardiore …
19.08.2026
Yinan Wu, Chang Li, Shangxin Liu, Huiping Chen, Yongyi Chen, Xinyu Chen, Yumei Wang, Yuan Qin, Zhong Yi, Pengjun Zhang, Biyan Jiang, Jianye Wang, Bei LaiABSTRACT China's demographic landscape is undergoing a dramatic transformation. With over 297 million people aged 60 and above—comprising 21.1% of the total population—the nation faces unprecedented challenges in providing adequate end‐of‐life care for its elderly citizens. It is …
13.08.2026
Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics SocietyABSTRACT Chronic respiratory diseases pose a serious threat to the health of the population due to their high incidence, high disability rate, and poor prognosis. It is necessary to improve the prevention and treatment status of chronic respiratory diseases. Vaccination against i …
13.08.2026
Lu Wei, Yao Ma, Xueqi Chen, Xinran Ni, Yu Zhang, Bei Zhu, Qun Zhang, Weihong ZhaoABSTRACT Objectives Kidney function declines with aging, leading to a high prevalence of age‐related disease. Concurrently, the increasing prevalence of overweight and obesity may influence age‐related kidney changes. This study aims to clarify the relationship between body mass …
12.08.2026
Daiping Li, Chao Gao, Xiaoli Huang, Ling Kang, Birong Dong, Jirong Yue, the Specialized Committee for Geriatric Medicine of the STARABSTRACT Objectives This study aims to evaluate the Scientific, Transparent, and Applicable Rankings (STAR) of guidelines and consensus published in Chinese geriatric medicine journals in 2023. Methods The working group conducted a systematic search in eight major Chinese and Eng …
23.03.2026
Hongman Wang, Bo Xie, Can Liu, Yifan SongABSTRACT Objective This article conducted a bibliometric analysis on research of older adults' health and physical activity (PA) to enrich the academic community's comprehension and research of this field. Methods A total of 10,778 documents published from 1900 to 2023 were inclu …
11.06.2026
Yawen Zhang, Junchuan Liu, Maoyu Zhao, Yudian Qiu, Quan Ji, Nan Min, Qiang WangABSTRACT Objective To investigate the relevant factors of augmented vertebrae recollapse after percutaneous vertebral augmentation (PVA) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Method A prospective study was performed on 116 patients who were di …
15.06.2026
Francesco Salis, Maristella Belfiori, Alessandro Ferrau, Eleonora Bernardini, Emanuele Concas, Anna Maria Lugas, Antonella MandasABSTRACT Objectives Depression screening tools like the Patient Health Questionnaire‐2 (PHQ‐2) are commonly used to detect depression. However, its performance in elderly populations has been less extensively studied compared to its broader adult use. This study evaluates the PHQ …
11.06.2026
Haodong Wei, David Mockler, Giulia Cavrini, Nathan W. Hill, Daniel Kam Yin Chan, Román Romero OrtuñoABSTRACT Frailty is increasingly recognized as a central concept in aging research and clinical practice, which reflects reduced physiological reserve and heightened vulnerability to stressors. While extensively examined in Western biomedical literature, how frailty is defined an …
15.06.2026
Jianxia Ma, Jun Wang, Tianran Han, Zhifang Shao, Weiqi Zhang, Ke Wang, Qinlian Zeng, Kangwei Liu, Yuanwen Chen, Songbai Zhen, Jianfeng YaoABSTRACT Objectives To evaluate the efficacy of lactulose in the treatment of elderly constipation patients with chronic renal insufficiency and its influence on renal function. Methods They were divided into the lactulose group ( n = 30) and polyethyleneglycol (PEG) group ( n = …
27.06.2026
Yuheng Wang, Qingqing Ding, Lei Xue, Jinhua LuoABSTRACT Objectives To investigate the lymph node metastasis (LNM) pattern of esophageal squamous cell carcinoma (ESCC) and identify factors associated with LNM: Methods A retrospective study was conducted including 388 patients with ESCC who underwent curative resection at the F …
08.06.2026
Md. Abu Sayem, Md. Golam Hossain, Md. Mothashin, Md. Nurul IslamABSTRACT Objective Morbidity is a prevalent public health issue especially among the aging population worldwide. As the risks of morbidity increase with age, aging populations increasingly become a socioeconomic burden on their families. However, studies on morbidity among aging …
09.07.2026
10.1002/agm2.7009811.06.2026
Yunpeng Liu, Yiqi Liu, Zeping Jin, Jumei Huang, Yang WangABSTRACT Objectives To investigate the impact of early postoperative blood pressure variability (BPV) on 90‐day functional outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS‐LVO) undergoing mechanical thrombectomy, and to assess its interaction wit …
11.06.2026
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin LiuABSTRACT Objective To investigate the longitudinal pathological changes in the spectrum of biopsy‐proven renal diseases among elderly patients over the past 20 years at a single center in China. Methods We retrospectively enrolled patients aged ≥ 60 years who underwent renal biop …
28.06.2026
Mohammad Reza Shadmand Foumani Moghadam, Mostafa Shahraki Jazinaki, Sharif Etemadi, Kazem Eslami, Pegah Meghdadi, Parnian Pezeshki, Mohammad Amoushahi, Reyhane Bakhshipour, Majid Ghayour Mobarhan, Majid Khadem‐Rezaiyan, Reza Rezvani, Zohre HosseiniABSTRACT Objectives Sarcopenia, an age‐related muscle disease, is influenced by a variety of factors, making it essential to explore the associations of physical activity, psychological health, employment, and exercise with this condition in a healthy, well‐nourished population. …
05.06.2026
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping HeABSTRACT Sarcopenia is an age‐related skeletal muscle disorder characterized by progressive declines in muscle mass, strength, and physical function, which profoundly impair quality of life in older adults. Although current clinical guidelines propose various diagnostic approache …
28.05.2026
Yuhui Chen, Fan Feng, Sicong Wang, Qi Wang, Hua Wang, Min Chen, Tao Gong, Chunmei LiABSTRACT Objectives Frailty, a common condition in the elderly, is characterized by a decline in physiological reserves and an increased vulnerability to stressors, leading to negative health outcomes such as falls, fractures, and prolonged recovery from illness. Despite its clin …
25.05.2026
Ashkan Sadeghi, Safoura Alizade, Mohammad Faramarzi, Mostafa Rahimi, Rohit Kumar ThapaABSTRACT Objectives Sarcopenia, characterized by age‐related muscle loss, worsens in diabetes due to anabolic resistance. Ursolic acid (UA), a natural compound with anabolic and anti‐catabolic effects, may mitigate sarcopenia by enhancing anabolic pathways. This study examined th …
30.04.2026
Pei Ding, Kevin Jasas, Victoria Bray, Abhijit Pal, Rebecca MoorABSTRACT Objectives Limited data exist on real‐world treatment strategies and their impact on survival in Australian patients with NSCLC. THASSOS‐INL (NCT04808050) evaluated the treatment patterns and survival outcomes in patients with early‐stage NSCLC. Methods Australia cohort …
26.04.2026
Christina Malini Christopher, Bhuvan KC, Mark Wing Loong Cheong, Rajeev Shrestha, Sunil Shrestha, Juman Dujaili, Ali BlebilABSTRACT Background Deprescribing is a systematic approach aimed at reducing the number of medications that are no longer beneficial or appropriate. This study aims to assess the various types of deprescribing and the outcomes among older adults in primary health care. The electr …
03.05.2026
Xiyin Chen, Shaoxiang Jiang, Muqi Guo, Hao Zhang, Mouwang Zhou, Yao YaoABSTRACT Objectives Urinary incontinence (UI) significantly deteriorates the quality of life in the elderly, with a disproportionately higher burden among women. With populations aging in the USA and the UK, understanding the gender‐specific prevalence, determinants, and future c …
30.04.2026
Jiajun Liang, Yuan Xue, Yeting Lou, Hao Han, Xiaohan Zhong, Zhou Liu, Tianxu Han, Meili Wang, Wenjian Jiang, Hongjia Zhang, Haiyang Li, Yuanfei ZhaoABSTRACT Objective The clinical efficacy and early outcomes of total arch replacement with frozen elephant trunk (TAR+FET) in elderly patients presenting with acute type A aortic dissection (ATAAD) remain incompletely characterized. This study aimed to comprehensively evaluate ea …
12.05.2026
10.1002/agm2.7008523.04.2026
Minmin Chen, Xiaoqing Wu, Yanping Du, Wenjing Tang, Weijia Yu, Huilin Li, Qun ChengABSTRACT Objectives Low skeletal muscle mass is associated with adverse clinical outcomes. Due to constraints related to cost and equipment availability, direct measurement of skeletal muscle mass is often not feasible in routine practice. This study aimed to develop and validate …
30.04.2026 · 1 Zitationen
Bi Jianghan, Li Jiaojiao, Kang LinABSTRACT The Asian Sarcopenia Working Group has released its latest 2025 consensus update. This narrative review interprets key changes in the AWGS 2025 consensus including: for the first time the working group establishes a conceptual framework centered on muscle health promotio …
26.04.2026
Dipak Chandra Das, Moustaq Karim Khan Rony, Shovit Dutta, MD. Sami Al Zubair Zujbe, Tapan Bhattacharjee, Niloy Debnath, Shabbir Abdullah Maruf, Chowdhury Galib Mortuza, Farhana Rahman, Akash DasABSTRACT Older adults face increased risks of medication non‐adherence, adverse drug events, and polypharmacy due to chronic health conditions and complex drug regimens. Traditional medication management approaches often fall short in addressing these challenges. Artificial intel …
24.04.2026 · 1 Zitationen
Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne BouterABSTRACT Objectives Therefore, in the present study, the CB1 receptor (CB1R) expression in the hippocampal and cortical tissue of a clinically and neuropathologically characterized cohort of AD patients was analyzed. Methods Post‐mortem brain tissue from patients with sporadic AD …
23.04.2026
Giovanna Bubbico, Federica Tomaiuolo, Carlo Sestieri, Golnoush Akhlaghipour, Alberto Granzotto, Antonio Ferretti, Mauro Gianni Perrucci, Stefano L. Sensi, Stefano Delli PizziABSTRACT Objectives Neuroimaging studies suggest that Foreign Language Learning (FLL) influences resting‐state functional connectivity (rs‐FC) within the neocortex, but its effects on subcortical–cortical connectivity remain unclear. We hypothesize that FLL may specifically affec …
23.04.2026 · 1 Zitationen
Bingyu Huang, Zhao Peng, Lin KangABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease states. Its prevention and management represent a critical aspect of geriatric care and multi‐mor …
30.04.2026
Mengxia Gu, Qixiang Sun, Yujia Huang, Yuetian Deng, Xiaohong JiangABSTRACT Objective The research analyzed the clinical characteristics of geriatric and nongeriatric asthma cases, aiming to provide new insights into the diagnosis and management of geriatric asthma for clinicians. Methods This retrospective study analyzed data from the First Aff …
20.02.2026
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long FengABSTRACT The aging process is an inevitable and universal phenomenon characterized by a decline in function that all living organisms must undergo. The challenges posed by population aging, along with senile degeneration and cognitive disability, have emerged as pressing public h …
15.02.2026 · 1 Zitationen
Timothy Daly07.03.2026
Xinlong Ke, Qiaoxin Wei, Yijing Li, Jie Shen, Zhengli Guo, Bingqing Xu, Kaiyu Zhang, Juan Xia, Zhaoyuan Sheng, Yihui XuABSTRACT Objective This study aimed to evaluate the feasibility of the NPS for predicting sarcopenia in adults and to explore potential interventions or mechanistic links to mitigate sarcopenia risk. Methods This study included two distinct cohorts as follows: 282 patients from t …
20.02.2026
Ming Zhang, Tao Li, Dag Aarsland, Xiaozhen Lv, Jing Wang, Teng Xie, Xin Yu, Huali WangABSTRACT Objectives Given that DLB is the second most common neurodegenerative dementia and early detection is crucial, this study sought to delineate the pre‐diagnostic symptom evolution in patients from a Chinese memory clinic. Methods Prospective patients diagnosed with probab …
17.03.2026
10.1002/agm2.7007219.02.2026 · 1 Zitationen
Md. Biplob Hossain, Md. Imdadul Haque, Md. Monir Hossain Shimul, Rebeka Jesmin Sarker, Syed Nazmus Sakib, Ajahar Islam Hridoy, Kausar Ahammed Nishat, Foysal Ahmed, Mohammed Nadir Bin Ali, Hafiz T. A. Khan, Salim Khan, ABM Alauddin ChowdhuryABSTRACT Objectives This study aimed to estimate the prevalence of geriatric depression and identify its associated socio‐demographic, lifestyle, health, and psychosocial determinants among community‐dwelling older adults in Bangladesh. Methods A community‐based cross‐sectional s …
11.03.2026
National Center of Gerontology, Lung Cancer Committee of Beijing Oncology Association, Editorial Board of Chinese Journal of Geriatrics, Li Lin, Nie Xin, Wei Qian, Li Xu, Tian Yumeng, Wu Lin, Wang Jingyi, Wang Zhijie, Wang Mingzhao, Cao Baoshan, Gu Yangchun, Huang Meijuan, Yu Min, Yang Bo, Song QiABSTRACT Immune checkpoint inhibitors (ICIs) are an important treatment option for patients with advanced non‐small cell lung cancer (NSCLC). There remains significant uncertainty regarding immunotherapy regimen selection and safety management for elderly lung cancer patients, du …
10.01.2026
Amelia Ravindran, Palanisamy Sivanandy, Sajesh Kalkandi Veettil, Priya ManirajanABSTRACT Objectives The affordability of medication is a crucial factor influencing individual adherence to prescribed treatments. Fluctuating medication prices at community pharmacies can negatively affect long‐term adherence and contribute to poor health outcomes. Therefore, th …
