Wissenschaftliches Journal · EZB

Alzheimer s Research & Therapy

Springer (Biomed Central Ltd.)

ISSN 1758-9193kostenlos

In EUVIMED recherchieren

Artikel gesamt2.401

Aktueller Bestand841

Jahrgänge18

Aktuellster Jahrgang2026

Inhaltsverzeichnis

2026 · 239 Beiträge

Jahrgang 2026Online First / fortlaufend17.09.2026 · 55 Beiträge

ePub

17.09.2026

Shenjia Wu, Jinsen Liang, Yanping Liu, Zhuo Wang, Yihe Wu, Xin Liang, Huayi Huang, Lilan Xin, Feiyan Xie, Tian Li, Zhichao Xu, Tao Wang, Hai-Bing Zhou, Junjian Zhang

ePub

12.09.2026

Hei Tong Pang, Kenneth Nai Kuen Fong, Tenaw Gualu Melesse, Raymond Chung, Jack Jiaqi Zhang, Hui-Chieh Ju

ePub

11.09.2026

Tobi Van den Bossche, Fahri Küçükali, Anne Sieben, Jasper Van Dongen, Sebastiaan Engelborghs, Peter P De Deyn, Rik Vandenberghe, Mathieu Vandenbulcke, Tim Van Langenhove, Olivier Deryck, Julie van der Zee, Christine Van Broeckhoven, Patrick Cras, Kristel Sleegers

ePub

11.09.2026

Maria Luisa De Paolis, Gilda Loffredo, Claudio Zaccone, Livia La Barbera, Emma Cauzzi, Irene Ferrari, Luana Saba, Ramona Marino, Annalisa Nobili, Paraskevi Krashia, Marcello D’Amelio

ePub

11.09.2026

Xiaoyun Feng, Xiaorui Li, Anlin Cai, Wanchen Liao, Jun Li, Xiong Guo, Haiquan Long, Ping Luan

ePub

10.09.2026

Noelia Fandos, María Pascual-Lucas, Leticia Sarasa, Jorge Loscos, Jose Terencio, Juan Pablo Tartari, Angela Sanabria, Oscar Sotolongo-Grau, Amanda Cano, Montserrat Alegret, Lluís Tárraga, Miren Jone Gurruchaga, Agustín Ruiz, Xavier Montalban, Mercè Boada, Marta Marquié, José Antonio Allué, the FACEHBI study group, N. Aguilera, E. Alarcón-Martín, J. A. Allué, P. Bayón-Bujan, M. Berthier, J. Blázquez-Folch, M. Buendia, S. Bullich, F. Campos, B. Calm-Salvans, F. Casales, P. Cañabate, L. Cañada, C. Cuevas, I. de Rojas, S. Diego, G. Domingues-Kolinger, J. M. Escudero, A. Espinosa, M. V. Fernández, A. Gailhajenet, P. García-González

ePub

10.09.2026

Shijun Hu, Fuxiang Li, Xi Li, Xiao-Hui Deng, Chang-Lin Lian, Dong-Xiao Lou, Hui Liang, Yumeng Li, Man Chen, Lianwan Zhou, Qing Chen, Qing-Ling Fu, Ting Wu, Tao Liu

ePub

09.09.2026

Junwon Park, Sunghwan Kim, Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Suhyung Kim, Hyun Kook Lim

ePub

09.09.2026

Takayuki Asano, Setsuo Kinoshita, Asako Yasuda, Eisuke Inoue, Masahiro Shigeta

Abstract Background Dementia affects more than 55 million people worldwide, and mild cognitive impairment (MCI) represents a critical window for early intervention. However, current neuropsychological assessments require specialist expertise and extended administration time, limi …

ePub

07.09.2026

Chiara Giuseppina Bonomi, Guido Greco, Caterina Motta, Diego Centonze, Alessandro Martorana

ePub

05.09.2026

Kristine Beate Walhovd, Anne Ingeborg Berg, Sandra Buratti, Jonas Burén, Pär Bjälkebring, Martin Fischer, Isabelle Hansson, Linda Hassing, Anna-Carin Jonsson, Lina Jonsson, Magnus Lindwall, Therese Nilsson, Andreas Segerberg, Valgeir Thorvaldsson, Mikael Landén, Alli Klapp, Martin Lövdén

Abstract Background Higher cognitive ability in late adolescence and young adulthood associate with reduced risk of dementia, but such assessments are influenced by educational selection. Whether specific cognitive abilities earlier in childhood associate with later dementia risk …

ePub

05.09.2026

Yasmine Salman, Thomas Gérard, Lara Huyghe, Lise Colmant, Vincent Malotaux, Jean-Louis Bayart, Emilien Boyer, Flo Blondiaux Pirson, Pascal Kienlen-Campard, Laurence Dricot, Renaud Lhommel, Adrian Ivanoiu, Lisa Quenon, Bernard J. Hanseeuw

ePub

05.09.2026

Hsing-Yu Hsu, Ting-Yuan Liu, Wei-Chun Wang, Ke-Wei Chen, Yih-Dih Cheng, Shih-Sheng Chang, Fuu-Jen Tsai

ePub

05.09.2026

Xiangrui Liu, Mei Chen, Yu zhuo Dan, Rui Gong, Jing Su, Kejie Deng, Hulin Long, Cheng Qiu, Lei Zhang, Yang He, Shijing Wang, Tao Qin

Abstract Objective To evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) on global cognitive function in patients with mild-to-moderate Alzheimer’s disease (AD), explore the moderating effects of different treatment parameters, and provide evidence-based …

ePub

03.09.2026

Duohao Wang, Tingting Wang, Feng Li, Chi Zhang, Wei Li, Xinyang Qi, Qun Yao, Xing Ye, Xingjian Lin, Minjie Tian, Jingping Shi

ePub

28.08.2026

Xuehui Mao, Qian Yu, Ruidan Chen, Shuyi Yu, Zhikang Cui, Hang Chen, Xiaoyi Zhao, Qingyao Li, Shiqing Cheng, Ming Li

ePub

27.08.2026

Donghe Li, Xudong Han, Ting F. A. Ang, Joseph N Palmisano, Yorghos Tripodis, Katherine W. Turk, Maureen K. O’Connor, Lee E. Goldstein, Andrew E. Budson, Wei Qiao Qiu, Michael L. Alosco, Rhoda Au, Ann C. McKee, Jesse Mez, Thor D. Stein, Lindsay A. Farrer, Gyungah R. Jun

ePub

24.08.2026

Siqi Tian, Gekang Zhao, Yi Zhang, Di Yang, Xiaodan Zhang, Yan-Zhong Chang, Guofen Gao

ePub

20.08.2026

Karin L. Meeker, Julie K. Wisch, Melissa E. Petersen, James Hall, Ganesh M. Babulal, Kristine Yaffe, Robert A. Rissman, Ann D. Cohen, Sid E. O’Bryant, Beau M. Ances, The HABS‐HD Study Team, Arthur Toga, Leigh Johnson, Meredith Braskie, Kevin King, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Matthew Borzage, Michelle Mielke, Jorge Llibre-Guerra, Carl Hill

ePub

15.08.2026

Joanna Komorowska, Sanskar Ranglani, Heather McCann, Claire E Shepherd, Michael Bratslavsky, Thomas Seymour, Sibah Hasan, Jason L. Oke, Sara Garcia-Rates, Susan A Greenfield

ePub

14.08.2026

Peter R Millar, Stephanie Doering, Babatunde Adeyemo, Saurabh Jindal, Nicole S McKay, Jeremy F Strain, Julie K Wisch, Gordon Zhaoqi An, Pete Canfield, Shaney Flores, Nicholas V Metcalf, June Roman, Carlos Cruchaga, Jason J Hassenstab, David M Holtzman, John C Morris, Brian A Gordon, Beau M Ances, Tammie LS Benzinger

ePub

14.08.2026

Sophie Mutel, Federica Ribaldi, Augusto J. Mendes, Daniele Altomare, Cecilia Boccalini, Claire Chevalier, Miguel A. Frias, Ilse Kern, Moira Marizzoni, Debora Peretti, Chen Wang, Valentina Garibotto, Aurélien Lathuilière, Giovanni B. Frisoni

Abstract Background Accurate detection of Alzheimer’s disease (AD) pathophysiological changes is crucial for research and clinical practice. While positron emission tomography (PET) imaging is an established reference standard for detecting brain amyloid and tau deposition, cereb …

ePub

12.08.2026

Heikki E. M. Lukkarinen, Antti J. Luikku, Antonios G. Dougalis, Anssi Pelkonen, Mireia Gomez-Budia, Polina Abushik, Nataliia Novosolova, Henna Jäntti, Antti-Pekka Elomaa, Aku Kaipainen, Nikolai Klimko, Paula Walle, Henna-Kaisa M. Jyrkkänen, Nils Danner, Katri Piilonen, Nora E. Firtser, Arto Immonen, Juha E. Jääskeläinen, Ross W. Paterson, Kristopher T. Kahle, Per Kristian Eide, Evan Macosko, Beth Stevens, Valtteri Julkunen, Eino Solje, Mari Takalo, Sini-Pauliina Juopperi, Susanna Kemppainen, Henna Martiskainen, Anssi Lipponen, Mikko Hiltunen, Tuomas Rauramaa, Tarja Malm, Ville Leinonen

Abstract Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathol …

ePub

11.08.2026

Federico Massa, Anastasia Lechiara, Francesca De Cesari, Virginia Pelagotti, Alessia Panza, Giulia Bozzo, Martina Urbinati, Mattia Losa, Stefano Raffa, Emanuela Maria Mobilia, Federica Maria Bozzano, Davide Visigalli, Luigi Lorenzini, Andrea Brugnolo, Nicola Girtler, Dario Arnaldi, Angelo Schenone, Antonio Uccelli, Gianmario Sambuceti, Silvia Morbelli, Giampaola Pesce, Matteo Pardini

Abstract Background In Alzheimer’s disease(AD), core CSF biomarkers incompletely predict clinical progression. Synaptic biomarkers may add prognostic information by capturing distinct biological dimensions, from synaptic injury to adaptive network function. Although correlated, n …

ePub

11.08.2026

Julie F. H. De Houwer, Wenjie Kang, Renee van Buuren, Liset de Boer, Tine Swartenbroekx, Ana Rajicic, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry-Bolder, John C. van Swieten, Lize C. Jiskoot, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Yolande A. L. Pijnenburg, Charlotte Teunissen, Jonathan D. Rohrer

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re …

ePub

08.08.2026

Xinchong Shi, Haifan Kong, Weineng Chen, Lishan Lin, Kang Yuan, Fengjuan Su, Yating Wang, Ya Zhang, Jiayi Zhou, Xianbo Zhou, Curtis B. Ashford, Feng Li, J Wesson Ashford, Michael F. Bergeron, Zhong Pei, Yifan Zheng, Wenbiao Xian

ePub

01.08.2026

Liwei Ma, Yihan Wang, Benjamin Goudey, Liang Jin, Yijun Pan

ePub

29.07.2026

Suzie Kamps, Esmé H. J. Habraken, Suzan van Amerongen, Dirk N. van Paassen, Sterre C. M. de Boer, Emma M. Coomans, Sietske A. M. Sikkes, Philip Scheltens, Rik Ossenkoppele, Everard G. B. Vijverberg

Abstract Background Repetitive head impacts (RHI) are associated with an increased risk of neurodegenerative disease, most notably chronic traumatic encephalopathy (CTE). This study characterized neuropsychological profiles of RHI-exposed individuals compared to unexposed control …

ePub

23.07.2026

Ahmed Negida, Sarah K. Lageman, Kenchiro Ono, Moinul Ahsan, Nitai Mukhopadhyay, Matthew J. Barrett

Abstract Background Cognitive fluctuations (CF) are a core feature of Lewy body dementia (LBD) that negatively impact quality of life. Despite their prevalence and negative impact, CF are challenging to identify clinically. The goal of this study was to identify easily obtainable …

ePub

21.07.2026

Sonia Bonnì, Romina Esposito, Lucia Mencarelli, Francesco Di Lorenzo, Francesco Ricci, Fulvia Di Iulio, Elena Savastano, Francesca Candeo, Francesca De Masi, Antonella Coletta, Andrea Carolina Vinci, Matteo Ferraresi, Marta Mancini, Elias Paolo Casula, Ilaria Borghi, Danny Adrian Spampinato, Michele Maiella, Alex Martino Cinnera, Martina Assogna, Matilde Bruno, Matteo Nocilli, Marica Ferrara, Marta Russo, Nevio Luigi Tagliamonte, Clarissa Ferrari, Salvatore Bertino, Rocco Salvatore Calabrò, Maria Grazia Maggio, Rosaria De Luca, Rachele Burrascano, Elvira Gjonaj, Alessio Mirabile, Paolo De Pasquale, Andrea d’Avella, Angelo Quartarone, Giacomo Koch

ePub

17.07.2026

Alya Al-Awlaqi, Lori Berckmans, Sam De Waegenaere, Sarah Vanherle, Joseph Griffis, Ilse Dewachter, Marleen Verhoye, Mohit H. Adhikari

ePub

16.07.2026

Frederika Malichova, Peter Swann, Stacey L. Kigar, Natalia Savinykh Yarkoni, Julia Goddard, Kei Onn Lai, Leonidas Chouliaras, Ajenthan Surendranathan, Lorinda Turner, George Savulich, Richard Bevan-Jones, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Edward Needham, Joanne Jones, William A. McEwan, James B. Rowe, John T. O’Brien, Maura Malpetti

Abstract Background There is increasing evidence for the role of central and peripheral inflammation across neurodegenerative disorders, with animal models and post-mortem studies identifying T-cell infiltration in the brain associated with pathology and neurodegeneration. Periph …

ePub

15.07.2026

Hamed Azami, Yuri Antonacci, Daniel M. Blumberger, Heather Brooks, Luca Faes, Corinne E. Fischer, Alastair Flint, Nathan Herrmann, Sanjeev Kumar, Damien Gallagher, Linda Mah, Benoit H. Mulsant, Nicole Schoer, Bruce G. Pollock, Tarek K. Rajji, the PACt-M. D. Study Group

ePub

15.07.2026

Jingxiang Wen, Guoyu Lan, Yuan Fu, Weiru Jiang, Bin Xu, Jing Zhang, for the Alzheimer’s Disease Neuroimaging Initiative

ePub

15.07.2026

Tik Muk, Asger Wretlind, Kourosh Hooshmand, Marc Clos-Garcia, Yue Liu, Anja Hviid Simonsen, Laura M. Winchester, Tarunveer S. Ahluwalia, Petroula Proitsi, Riccardo E. Marioni, Thomas Kümler, Steen Gregers Hasselbalch, Cristina Legido-Quigley, Alzheimer’s Disease Neuroimaging Initiative

Abstract Background Alzheimer's disease (AD) disproportionately affects women, yet existing studies have been limited to single biofluids, individual hormones, or single dementia subtypes, leaving sex-stratified profiles across the cognitive impairment spectrum poorly defined. He …

ePub

14.07.2026

Hyemin Jang, Jae Woo Kim, Jung Won Hwang, Da Woon Jeong, Jeongeun Ka, Da Min Kang, Chong Hyun Suh, Yangsean Choi, Minyoung Oh, Jae Seung Kim, Jae-Sung Lim, Jae-Hong Lee

ePub

11.07.2026

Giuseppe Mario Bentivenga, Angela Mammana, Simone Baiardi, Erica Vittoriosi, Andrea Mastrangelo, Edoardo Ruggeri, Claudia Marina Vargiu, Barbara Polischi, Michelangelo Stanzani-Maserati, Giovanni Rizzo, Roberta Pantieri, Alberto Raggi, Sabina Capellari, Piero Parchi

ePub

11.07.2026

Chaynita Dashora, Anant Bahadur Patel

Abstract Background Alzheimer’s disease (AD) is characterized by the extracellular accumulation of amyloid-β (Aβ). Brain glucose hypometabolism, an early feature of AD, reflects neuronal metabolic dysfunction before the onset of clinical symptoms. While Aβ plaques are central to …

ePub

11.07.2026

Bastiaan G J van Tol, Colin Groot, Marie R Vermeiren, Elsmarieke van de Giessen, Yolande A L Pijnenburg, Emma M Coomans, Rik Ossenkoppele

Abstract Background [ 18 F]flortaucipir tau-PET detects neurofibrillary tangle (NFT) pathology in Alzheimer’s disease (AD), one of the core pathological hallmarks of the disease. In clinical settings, tau-PET is usually interpreted qualitatively, and therefore quantitative estima …

ePub

09.07.2026

Qiang Zhang, Jordan L Schultz, Jacob E Simmering, Braedon Q Kirkpatrick, Matthew A Weber, Sydney Skuodas, Tara Hicks, Grace Pierce, Margaret Laughlin, Benu George, Aimee X Bertolli, Travis Larson, Ramasamy Thangavel, Mayu Oya, David K Meyerholz, Georgina Aldridge, Jan Fassler, Nandakumar S. Narayanan

Abstract Background Terazosin (TZ) is widely prescribed for hypertension and benign prostatic hyperplasia. Recent studies suggest that TZ enhances glycolysis and may protect against neurodegenerative diseases. Methods We tested the hypothesis that TZ is neuroprotective in Alzheim …

ePub

06.07.2026

Chun-Ting Yang, James M. Wilkins, Aaron S. Kesselheim, Dae Hyun Kim, Kueiyu Joshua Lin

ePub

03.07.2026

Tyler R. Bell, Carol E. Franz, Christine Fennema-Notestine, Erin E. Sundermann, Shelby B. Hughes, Matthew S. Panizzon, Imanuel Lerman, Jeremy A. Elman, William S. Kremen

Abstract Background Growing evidence supports chronic pain (CP) as a risk factor for Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). We examined whether CP is associated with longitudinal worsening of AD-related biomarkers, brain structure, and cognition, …

ePub

02.07.2026

Erin K. Murphy, Kathleen Hatch, Stephen Y. Wise, Oluseyi O. Fatanmi, Sarah A. Petrus, Manish Bhomia, Daniela Lecca, Barbara E. C. Knollmann-Ritschel, Daniel P. Perl, Vijay K. Singh, Diego Iacono

ePub

30.06.2026

Inge M. W. Verberk, Lotte A. de Koning, Emma M. Coomans, Calvin Trieu, Anna E. Leeuwis, Jacob Hunter, Lee Honigberg, Wiesje M. van der Flier, Everard G. B. Vijverberg, Rik Ossenkoppele, Elsmarieke van de Giessen, Charlotte E. Teunissen

Abstract Background Patients with Alzheimer’s disease (AD) with a low to intermediate tau-PET burden might benefit most from anti-amyloid treatment. Staging tau burden with plasma biomarkers would offer a scalable alternative to staging with tau-PET. This study investigated wheth …

ePub

29.06.2026 · 1 Zitationen

Noa Bregman, Nuno Pedrosa de Barros, Talya Nathan, Mori Hay Levy, Diana Sima, Simon Van Eyndhoven, Aya Bar-David, Orna Aizenstein, Dana Niry, Lilian Atlan, Anan Abu Awad, Elissa Ash, Nurit Omer, Tamara Shiner

Abstract Introduction Lecanemab, a monoclonal antibody targeting amyloid beta, has demonstrated meaningful clinical benefits in early Alzheimer’s disease (AD), yet real-world data is needed to optimize patient selection and enhance safety monitoring, particularly with respect to …

ePub

29.06.2026

Wenshan Sun, Rong Xing, Jian Zhou, Yong Li, Gelin Xu

ePub

29.06.2026

Seong-Ho Moon, Min-Ho Kim, Jae-Hong Ryoo

ePub

27.06.2026 · 1 Zitationen

Elise Saul, Léa Chauveau, Brigitte Landeau, Jade Lasserve, Blandine Montagne, Emilie Foyard, Géraldine Poisnel, Gaël Chételat, Robin de Flores, for the Medit-Ageing Research Group

ePub

25.06.2026

Yi Ye, Danyang Wang, Jiayi Han, Shiyi Li, Manlei Chen, Yueling Sun, Fangjiang Li, Hongsen Tian, Le Wang, Wei Zhao, Xinhui Ning, Qing Chen, Xiaoyi Wang, Changsheng Ma, Xiaoping Liu, Yong Zeng

ePub

22.06.2026

Chuo-Yu Lee, Chih-Wei Hsu, Ping-Tao Tseng, Yi-Ya Fang, Brendon Stubbs, Trevor Thompson, Andre F. Carvalho, Yu-Hsuan Lin, Yu-Chen Kao, Fu-Chi Yang, Tien-Wei Hsu, Chih-Sung Liang

ePub

20.06.2026 · 1 Zitationen

Anita Monteverdi, Matteo Cotta Ramusino, Francesca Conca, Alberto Augello, Chiara Totaro, Paolo A. Grasso, Anna Castelnovo, Roberta M. Lorenzi, Michele Terzaghi, Lisa M. Farina, Alfredo Costa, Anna Pichiecchio, Stefano F. Cappa, Claudia Gandini Wheeler-Kingshott, Fulvia Palesi, Egidio D’Angelo

Abstract Background Mild Cognitive Impairment (MCI) is a heterogeneous clinical condition characterized by a wide spectrum of cognitive and behavioural manifestations. Despite numerous studies, the link between neuropsychological performance and pathophysiological signatures of t …

ePub

15.06.2026

Mark Sanderson-Cimino, Alden L. Gross, Leslie S. Gaynor, Emily W. Paolillo, Rowan Saloner, Marilyn S. Albert, Liana G. Apostolova, Brooke Boersema, Adam L. Boxer, Bradley F. Boeve, Kaitlin B. Casaletto, Hilary W. Heuer, Leah K. Forsberg, Savannah R. Hallgarth, Valentina E. Diaz, Lindsay R. Clark, Ani Eloyan, Sarah Tomaszewski Farias, Pauline Maillard, Mitzi M. Gonzales, Dustin B. Hammers, Renaud La Joie, Yann Cobigo, Amy Wolf, Benjamin M. Hampstead, Dawn Mechanic-Hamilton, Bruce L. Miller, Gil D. Rabinovici, John M. Ringman, Lina M. D’Orazio, Howie J. Rosen, Sephira G. Ryman, Jillian L. Prestopnik, David P. Salmon, Glenn E. Smith, Charles DeCarli, Kumar B. Rajan, Lee-Way Jin, Jason D. Hinman, David K. Johnson

Abstract Introduction List-learning tasks (LLTs) are important for characterizing memory in Alzheimer’s disease and related dementias. However, as the Uniform Data Set Neuropsychological Battery (UDS-NB) historically did not require a specific LLT, centers have administered diffe …

ePub

10.06.2026

Midas M. Kuilman, Shahzad Ahmad, Amos C. Pomp, Frank J. Wolters, Rima Kaddurah-Daouk, M. Arfan Ikram, Mohsen Ghanbari

Abstract Background Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ) and tau pathology, neuroaxonal damage, and neuroinflammation. While blood biomarkers, such as tau, neurofilament light chain (NfL), and Aβ isoforms, reflect …

ePub

09.06.2026

Carla Canal, Kevin Aguilar, Gemma Comes, Elisenda Sanz, Mercedes Giralt, Paula Sanchis, Juan Hidalgo

ePub

01.06.2026

Simin Yang, Xiong Xiao, Yuqian Yang, Yinqian Cai, Yuxi Zou, Yanping Tang, Huihan Ma, Zelin Lai

Abstract Background Circadian rest–activity rhythm disruption and sleep–wake fragmentation are common in Alzheimer’s disease (AD) and may precede clinical diagnosis. Wrist-worn accelerometry enables objective, scalable circadian phenotyping in population cohorts. We examined whet …

Band 18Ausgabe 114.09.2026 · 184 Beiträge

ePub

14.09.2026

Sandar Aye, Signe Åhrberg, Axel C Carlsson, Jan Hasselström, Ibrahim Alshamani, Sara Wallen, Wobbie van den Hurk, Lena Lund, Alenka Jejcic, Sarah Thomas Broome, Adrià Duran Sidera, Lars Tjernberg, Linus Jönsson, Sophia Schedin-Weiss

Abstract Background Timely detection of cognitive impairment due to Alzheimer’s disease (AD) is increasingly important as disease modifying therapies become available. Current diagnostic pathways in primary health care (PHC) rely mainly on clinical assessment and brief cognitive …

ePub

27.08.2026

Claudia Schwarz, Stefan Frenzel, Till Ittermann, Ulrike Grittner, Silke M Wortha, Tina Brzoska, Hans J Grabe, Agnes Flöel, Friedrich Ihler

Abstract Background Hearing loss has been reported as a major, potentially modifiable risk factor for dementia and often co-occurs with tinnitus. Both conditions are prevalent and have been linked to brain health and cognitive decline. However, evidence from studies containing th …

ePub

22.08.2026

Eric Hatterer, Lucile Broyer, Sara Pecoraro, Fabien Cusin, Naz Simsek, John J Breve, Mathieu Clavel, Kevin L. Batenburg, Bart Klein, Thuur Zuidweg, Kristin Piché, Jeremie Bourguignon, Margot Bonnet-Gamard, Pauline Malinge, Franck Gueneau, Valery Moine, Nadia Anceriz, Krzysztof Masternak, Nicolas Fischer, Torleif Tollefsrud Gjølberg, Jenny Skjermo Telstad, Gaia Calamera, Simone Mester, Wiep Scheper, Wilma D.J. Van de Berg, Jean-Philippe Courade

ePub

14.08.2026

Madison M. Reeves, Sara Aviles Carpintero, Matteo Zanovello, Karen Jansen-West, Mei Yue, Anna Calliari, Yuping Song, Judith Dunmore, Candela Maroto Cidfuentes, Sophie Ball, Jennifer M. Kachergus, Heather E. Killeen, Bailey Rawlinson, Erica Engelberg-Cook, Michael DeTure, Gregory S. Day, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Melissa Murray, Aubrey E. Thompson, Dennis W. Dickson, Pietro Fratta, Leonard Petrucelli, Keith A. Josephs, Mercedes Prudencio

ePub

07.08.2026

Lars Frings, Joachim Brumberg, Philipp T. Meyer

Abstract Background Semantic fluency is commonly assessed in the diagnostic work-up of individuals with suspected cognitive impairment due to neurodegenerative disease. Semantic fluency has a predictive value for survival in clinical AD and in healthy elderly individuals, but it …

ePub

23.07.2026 · 1 Zitationen

Ignazio Stefano Piras, Ana Werneck Capuano, Amanda Cook Maher, Rhiana Schafer, Anna Bonfitto, Serena Song, Francis Taguinod, Felicia Goldstein, Angela Roberts, Ozioma Okonkwo, Adam Martersteck, The SuperAging Research Initiative, AR Trammell, M Parker, L Kaddoura, G Harris, A Ellison, S Saleh, D Qui, H Ahmed, J Chung, B Stark, I Ayala, C Geula, M Mesulam, A Lim, RH Swartz, K Seibert, M Kharitonova, S McDermott, C Zolliecoffer, E Addison, H Peirce, J Engelmeyer, P Timpo, R Devine, S Moore, H Whitmore, M McCarthy, K Hearns

ePub

15.07.2026

Yanin Suksangkharn, Björn Hendrik Schott, Peter Zeidman, Niklas Vockert, René Lattmann, Hartmut Schütze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Lukas Preis, Ersin Ersözlü, Josef Priller, Eike Jakob Spruth, Janna Beckmann, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Ayda Rostamzadeh, Wenzel Glanz, Enise I. Incesoy, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Annika Spottke, Marie Kronmüller, Frederic Brosseron, Falk Lüsebrink, Matthias Schmid, Luca Kleineidam, Melina Stark, Stefan Hetzer, Peter Dechent, Frank Jessen, Anne Maass, Emrah Düzel, Gabriel Ziegler

Abstract Alzheimer’s disease (AD) is characterised by the accumulation of β-amyloid (Aβ) and tau proteins, resulting in neurodegeneration and cognitive decline. Although Aβ and tau disrupt synaptic function, the association linking these molecular pathologies to network-level dys …

ePub

11.07.2026

Tamar Abzhandadze, Minh Tuan Hoang, Xinqi Bao, Madeleine Åkerman, Jakob Norgren, Belén García Pascual, Minjia Mo, Maria Eriksdotter, Hong Xu, Sara Garcia-Ptacek

Abstract Background We conceptualize the Real-World Reassessment Threshold (RWRT) as representing the smallest change that exceeds expected measurement variability while accounting for clinically expected cognitive decline over the assessment interval, whereas the minimum clinica …

ePub

10.07.2026

Benjamin Kröger, Maria M. Ekblom, Hui-Xin Wang, Charlotta Thunborg, Miia Kivipelto, Rui Wang

Abstract Background The potential link between data-driven classifications of individuals’ activity profiles and the occurrence of fall and dementia, including within-person transitions from dementia- or fall-only states to their co-occurrence over time, remains unclear. Method T …

ePub

25.06.2026 · 1 Zitationen

Boru Jin, Aitong Li, Fengling Xu, Cong Chen, Jiawen Dong, Jingjing Wang, Dantong Tang, Ying Gu, Huayan Liu

Abstract Background Plasma phosphorylated tau-217 (p-tau217) is one of the most accurate blood-based biomarkers for Alzheimer's disease (AD), yet whether its diagnostic and correlational properties vary with age at onset has not been systematically examined. Methods We measured e …

ePub

24.06.2026

Miguel A. Labrador-Espinosa, Nicolai Franzmeier, Stamatia Karagianni, Alexis Moscoso, Michael Schöll

ePub

23.06.2026

Zhengxi Zhang, Qinqin Zhang, Yang Chen, Ruijie Zeng, Meizhen Min, Haolun Sun, Yujie Lai, Yingying Shen, Yuting Yang, Ming Feng, Zi Jin, Ying Zhang, Hebei Gao, Fan Lu, Yan-Jiang Wang, Meixiao Shen

ePub

22.06.2026

Gustaf Rådman, Amanda E. Denning, Sadhana Ravikumar, Nicola Spotorno, Ranjit Ittyerah, Lisa M. Levorse, John L. Robinson, Theresa Schuck, Sydney A. Lim, Eunice Chung, Madigan Bedard, Winifred Trotman, Alejandra Bahena, María del Mar Arroyo-Jiménez, Alicia Vela, Esther Buendia, Maria Mercedes Iñiguez de Onzoño Martin, María Pilar Marcos Rabal, Mónica Muñoz-López, Rosanna K. Olsen, John A. Detre, Edward B. Lee, David A. Wolk, Daniel T. Ohm, Corey T. McMillan, Ricardo Insausti, David J. Irwin, Paul A. Yushkevich, Laura E. M. Wisse, the Alzheimer’s Disease Neuroimaging Initiative

Abstract Background Hippocampal sclerosis of aging (HS-A), a common cause of dementia, can currently only be diagnosed at autopsy. We aimed to identify and evaluate MRI metrics to distinguish HS-A from Alzheimer’s Disease neuropathologic change (ADNC) and cases with limited/no pa …

ePub

22.06.2026 · 1 Zitationen

Jinwang Ye, Yunsong Deng, Bingge Zhang, Chengjia Li, Xing Guo, Ruizhu Yue, Huali Wan, Yue Hao, Shifeng Xiao

Abstract Background Astrocytes undergo reactive transformations in response to pathological stimuli and play a critical role in neuronal loss associated with Alzheimer’s disease (AD). However, the intrinsic mechanisms through which astrocytes detect amyloid-β (Aβ) pathology and d …

ePub

22.06.2026

Hanna E. Bodde, Jackie M. Poos, Guillaume H. P. R. Kolman, Angeline Bosman, Sten P. Willemsen, Kirsten Peetoom, Yolande A. L. Pijnenburg, Raymond Koopmans, Frans R. J. Verhey, Marjolein E. de Vugt, Christian Bakker, the PRECODE Study Group, Janne M. Papma

Abstract Background Young-onset dementia (YOD), defined as dementia with symptom onset before the age of 65, is associated with distinct and often complex care needs that differ from those with late-onset dementia. Current national data on YOD incidence, prevalence, and demograph …

ePub

20.06.2026

Yage Qiu, Wentao Hu, Yao Wang, Qingyang Fu, Ying Hu, Qun Xu, Hongjiang Wei, Yan Zhou, Yawen Sun

Abstract Background White matter hyperinxtensity (WMH) and normal-appearing white matter (NAWM) are critical markers for tracking disease progression in cerebral small vessel disease (CSVD), indicative of a spectrum of white matter injury . The core pathological alteration underl …

ePub

18.06.2026

Megan Kirk, Joseph Kwon, Kalliopi Mavromati, Adam Gordon-Boyle, Kamaldeep Bhui, Ivan Koychev, Sarah Bauermeister, Apostolos Tsiachristas

Abstract Introduction Plasma biomarkers of Alzheimer’s Disease and Related Dementias (ADRD) pathology may help clarify associations between modifiable risk factors (MRFs) and cognitive and functional impairment. Methods Cross-sectional data from 1002 adults (mean age 72.0 ± 6.7) …

ePub

18.06.2026 · 1 Zitationen

Emilly V. Figueiredo, Caroline Vieira Azevedo, Arlete Rita Penitente, Vinicius R. Pedrosa, Vinicius R. Camilo da Silva, Beatriz Monteiro Longo

ePub

16.06.2026 · 1 Zitationen

Irmak Gezginer, Maria Eleni Karakatsani, Prakruti Nanda, Pranati Chalasani, Diana Kindler, Rafael Storz, Markus Belau, Ruiqing Ni, Gerhard Schratt, Xosé Luís Deán-Ben, Daniel Razansky

Abstract Background Large-scale brain network dysfunction is increasingly recognized as an important feature of Alzheimer’s disease (AD), offering insight into disease mechanisms and opportunities for targeted therapeutic intervention. The spectral features of this dysfunction re …

ePub

16.06.2026

JiMin Kim, Dohui Ku, InWook Park, Suhyun Ye, Illhwan Cho, Minseol Park, Wonbin Seo, Sunhee Lee, Hye Yun Kim, Ikyon Kim, YoungSoo Kim

ePub

13.06.2026

Brooke D. Conway Kleven, Lung-Chang Chien, Dana Surwill, Michael L. Alosco, Jennifer V. Wethe, Yorghos Tripodis, Charles H. Adler, Martha E. Shenton, Ofer Pasternak, Douglas I. Katz, Elaine Peskind, Laura J. Balcer, Inga K. Koerte, Jesse Mez, Eric M. Reiman, Robert C. Cantu, Robert A. Stern, Henrik Zetterberg, Charles Bernick, Jeffrey L. Cummings

ePub

12.06.2026

Boris-Stephan Rauchmann, James Hamet, Jesyin Lai, Homeira Kafi, Joe Rexwinkle, Matthias Brendel, Nicolai Franzmeier, Carolin Kurz, Oliver Pogarell, Johannes Levin, Günter Höglinger, Robert Perneczky

Abstract Background Dementia affects over 50 million individuals globally, predominantly due to Alzheimer’s disease (AD). Effective early detection and intervention remain clinical challenges, as there is a lack of unified, portable solutions to assess multiple biomarkers. Method …

ePub

11.06.2026

Xiao Wu, Alexey Shadrin, Gabriëlla A. M. Blokland, Sinan Guloksuz, Ole A. Andreassen, David E. J. Linden, Dennis van der Meer

ePub

10.06.2026

Vincent Bouteloup, Cécile Proust-Lima, Isabelle Pellegrin, Andrea Boizard-Moracchini, Maëva Roy, Geneviève Chêne, Vincent Planche, Carole Dufouil, MEMENTO study group, Michèle Allard, Sara Amroun, Katia Andrade, Marion Andro, Daniela Andruita, Mariam Annan, Cédric Annweiler, Pierre Anthony, Marine Marine, Christine Astier, Alexandre Augier, Nicolas Auguste, Sophie Auriacombe, Clément Aveneau, John Avet, Carole Azuar, Laurent Laurent, Olivier Bailon, Anna-Chloe Balageas, Adeline Bannier, Fabrice-Guy Barral, Jean Barre, Marie-Odile Barrellon, Nicolas Bassiere, Catherine Bayle, Olivier Beauchet, Emilie Beaufils, Michèle BECKER Schneider, Yannick Bejot, Catherine Belin, Jérémie Belin

ePub

08.06.2026

Linsong Chai, Ying Zhan, Yunshi Huang, Meifang Tian, Guangning Zhao, Jinglei Ni, Xiao Xiong, Jia Huang, Bingbing Lin

ePub

06.06.2026

Andrea Contreras-Marciales, Daniela Mezquite-Garcia, Laura A. Verdina, Ahmed Elnahrawy, Tiara Wolf, Jennifer Guergues, Priyanshi Parikh, Elle R. Hunter, Diana Hernandez Acosta, Stanley M. Stevens, Shannon E. Hill, Laura J. Blair

Abstract The accumulation of pathogenic tau protein is linked to cognitive decline and neuronal loss in Alzheimer’s disease (AD), with tau oligomers identified as particularly neurotoxic. The 51 kDa FK506-binding protein (FKBP51) stabilizes these toxic tau oligomers and has been …

ePub

04.06.2026

Qu Li, Fenqin Chen, Rui Zhan, Wenqiang Cong, Siyu Mu, Shanshan Zhong, Xin Liu, Defu Zhao, Yueren Wang, Chuansheng Zhao, Kexin Kang, Zhike Zhou

ePub

03.06.2026

Katherine R. Sadleir, Karen P. Gomez, Sidhanth Chandra, Makenna L. Ley, Ammaarah W. Khatri, Joanna Guo, Yunlu Xue, Constance L. Cepko, Robert Vassar

ePub

03.06.2026

Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire-Regatillo, Lucie Liefooghe, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Inès Gallienne, Frank Lafont, Philippe Amouyel, Karine Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki-Wullich, Pierre Yger, Jean-Charles Lambert, Devrim Kilinc, Pierre Dourlen

Abstract Background Alzheimer’s disease (AD) is associated with strong genetic predisposition and early synaptic loss that correlates with cognitive decline. While genetic determinants are thought to contribute to synaptic vulnerability, their precise role in AD pathogenesis at t …

ePub

03.06.2026

Javier Oltra, Zuzana Ištvánfyová, Grégoria Kalpouzos, Ingrid Ekström, Göran Hagman, Miia Kivipelto, Erika J Laukka

Abstract Introduction Olfactory deficits, especially in odor identification (OID), have been linked to Alzheimer’s disease (AD), likely due to regional proteinopathy and atrophy in the olfactory brain circuit. Their cognitive and biological correlates across the clinical spectrum …

ePub

30.05.2026

Huamei Lin, Ying Zhang, Ruiqing Ni, Min Wang, Jianwei Men, Jingjie Ge, Jiaying Lu, Jing Wang, Huiwei Zhang, Yunhao Yang, Zhengwei Zhang, Yuhua Zhu, Hongguang Zhao, Tzu-Chen Yen, Junlong Wang, Kuangyu Shi, Axel Rominger, Yihui Guan, Min Fang, Jintai Yu, Jiehui Jiang, Chuantao Zuo

ePub

29.05.2026 · 1 Zitationen

Zhi Geng, Wenqian Song, Chen Gao, Yun Zhu, Yue Wu, Bo Song, Haihua Guo, Jiayun Wu, Miao Fang, Yibing Yan, Shanshan Zhou, Panpan Hu, Yanghua Tian, Xingqi Wu, Kai Wang, Ling Wei

ePub

29.05.2026

Jun Jia, Guomin Xie, Wu Zheng, Chunshuang Xu, Yuxin Xia, Qiaoxia Hu, Binbin Xiang, Xinkai Zhou, Anqi Chen, Xiaoping Chen, Qinwen Wang, Yingsong Zhou, Shujun Xu

Abstract Background Alzheimer’s disease (AD) is a progressive disorder characterized by cognitive decline. Physical exercise and audiovisual stimulation have gained increasing concern for their potential to mitigate AD pathology. However, the therapeutic advantages of combining t …

ePub

28.05.2026

Alexandra L. Clark, Elizabeth Valocchi, Makenna B. McGill, Francesca V. Lopez, Catherine Chanfreau-Coffinier, Kelsey R. Thomas, Dylan J. Jester, Mark W. Logue, Victoria C. Merritt

Abstract Background Although traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer’s disease and related dementias (ADRD), not all studies have shown a clear link between TBI and ADRD, suggesting that the relationship between TBI and ADRD is complex, nua …

ePub

28.05.2026

Sergio Escamilla, Carlos Avilés-Granados, Carmen Márquez-Marco, Maximilian Keller, Irene Sánchez-Domínguez, Inmaculada Cuchillo-Ibáñez, Fernando Aguado, Henrik Zetterberg, Claus U. Pietrzik, Javier Sáez-Valero

ePub

27.05.2026 · 1 Zitationen

N. Reijner, M. Riscado Ramos, E. Jacobs, D. V. Toen, B. Tijms, A. J. M. Rozemuller, L. van der Weerd, F. Barkhof, W. D. J. van de Berg, L. E. Jonkman

Abstract Background The T1-weighted/T2-weighted ratio (T1w/T2w-ratio) has been considered as a relatively simple neuroimaging approach to map myelin content in the aging and diseased brain. However, we hypothesize that any process affecting the tissue microstructural integrity al …

ePub

27.05.2026

Elizabeth McKiernan, Peter Swann, Elijah Mak, Maria Prats-Sedano, George Savulich, Allison Bentley, Guy Williams, Li Su, John T. O’Brien

Abstract The 7T-DLB study investigated whether atrophy of individual hippocampal and amygdala subfields is present in dementia with Lewy bodies (DLB) as well as in Alzheimer’s disease (AD) in which it has previously been established. MRI at standard clinical and research field st …

ePub

25.05.2026

Myuri Ruthirakuhan, Maya Mills, Paul Rosenberg, Norman Haughey, Jacobo Mintzer, Olga Brawman-Mintzer, Suzanne Craft, Nathan Herrmann, Alan J. Lerner, Allan I. Levey, Prasad R. Padala, Anton Porsteinsson, Christopher H. van Dyck, David Shade, Krista L. Lanctôt

ePub

23.05.2026

Hanxiao Xue, Sheng Bi, Meixi Wang, Xiaohua Zhu, Feng Wang, Yong Wang, Yujie He, Yan Wang, Xiaocao Liu, Bixiao Cui, Na Li, Zhilian Zhao, Chun Zhang, Liyong Wu, Zhigang Qi, Shaozhen Yan, Jie Lu

ePub

22.05.2026 · 1 Zitationen

Andrea E. Zülke, Melanie Luppa, Christian Sander, Ronny Baber, Ronald Biemann, Kerstin Wirkner, Samira Zeynalova, Silke Zachariae, Milica Matijevic, Christoph Engel, Nigar Reyes, Andreas Hinz, Heide Glaesmer, Matthias L. Schroeter, A. Veronica Witte, Arno Villringer, Markus Löffler, Carol Brayne, Steffi G. Riedel-Heller

Abstract Background Subjective cognitive decline (SCD) is considered an early preclinical marker for Alzheimer’s disease (AD). However, prevalence estimates vary widely due to inconsistent definitions. SCD Plus criteria were proposed by experts to improve specificity for preclini …

ePub

21.05.2026

Federico Coraglia, Giordano Cecchetti, Giulia Rugarli, Edoardo G. Spinelli, Alma Ghirelli, Stefano Pisano, Elisa Canu, Massimo Filippi, Federica Agosta

Abstract Background Apolipoprotein E (ApoE) ε4 status informs risk stratification and safety management for anti-amyloid therapies, but genotyping typically requires dedicated procedures, longer turnaround times, and higher costs compared with automated laboratory assays. We eval …

ePub

21.05.2026 · 1 Zitationen

Jehyun Ahn, Jihwan Yun, Michael W. Weiner, Daeun Shin, Heekyoung Kang, Sohyun Yim, Seonghyeon Kim, Heekyoung Park, Hyemin Jang, Min Young Chun, Eun Hye Lee, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI study group

ePub

21.05.2026

Parminder Singh Reel, Salim Al-Wasity, Craig Edwards, Smarti Reel, Esma Mansouri-Benssassi, Szabolcs Suveges, Muthu Rama Krishnan Mookiah, Susan Krueger, Emanuele Trucco, Emily Jefferson, Alexander Doney, J. Douglas Steele

Abstract Background Early identification of individuals at risk of dementia is essential for preventive care and timely enrolment into disease-modifying interventions. However, most existing prediction approaches rely on invasive, costly, or research-only biomarkers that are not …

ePub

20.05.2026

Jung-Lung Hsu, Shao-Yi Huang, Hsiu-Chuan Wu, Kun-Ju Lin, Kuo-Lun Huang, Chin-Chang Huang, SangYun Kim, Ing-Tsung Hsiao

ePub

20.05.2026

Xiaoshuai Li, Xuejia Li, Mengmeng Bai, Ling Yang, Jing Chen, Jiacheng Fan, Huijing Shi, Rui Li, Xiaoliang Liang, Shun Zhang, Pengfei Zhao, Jing Li, Han Lv, Shuohua Chen, Zhenghan Yang, Zhenjian Yu, Yuntao Wu, Ying Hui, Shouling Wu, Zhenchang Wang

ePub

20.05.2026 · 4 Zitationen

Rui Bao, Wanying Shi, Hongbo Bao, Tonghua Zhang, Xueying Li, Wencai Ding, for the A4 and LEARN Study; The Health and Aging Brain Study (HABS-HD) Study Team, Sid E O’Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Braskie King, James R Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Christian Bradley, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage

Abstract Background Early detection of Alzheimer's disease (AD) pathology in cognitively unimpaired individuals is critical for preclinical intervention. Plasma biomarkers, especially phosphorylated tau217 (p-tau217), are promising predictors of amyloid-β (Aβ) accumulation. Metho …

ePub

20.05.2026

Xin Xia, Alice Clark, Niels Juul Brogaard, Alex Mourer, Anna Areovimata, Maria Eriksdotter, Henrik Zetterberg, Silke Kern, Tobias Skillbäck, Linus Jönsson

ePub

19.05.2026

Ali Jannati, Sean Tobyne, Alvaro Pascual-Leone

ePub

19.05.2026

Katelynn E. Krick, Jessica L. Chalk, Joshua T. Lykins, Hsin-Pei Wang, Chloe A. Ferguson, Syed Salman Shahid, Erica M. Weekman, Donna M. Wilcock

ePub

19.05.2026

Paul W. Estes

Abstract Digital cognitive assessments represent an important and rapidly evolving approach to detecting cognitive impairment and Alzheimer’s disease–related pathology. Jannati et al. report promising findings using a multimodal digital clock and recall assessment to identify cog …

ePub

19.05.2026 · 1 Zitationen

Zsófia Lovró, Anders Sandberg, Henrik Zetterberg, Stefan Pierrou, Riitta Parkkola, Niclas Sjögren, Mika Scheinin, Juha O. Rinne

ePub

18.05.2026

Eva Skácelíková, Martin Vyhnálek, Filip Děchtěrenko, Tomáš Nikolai, Kateřina Veverová

ePub

14.05.2026

Dan Yang, Pinyi Liu, Mengxi Han, Zhihong Ke, Yi Tan, Linjie Yu, Zheqi Hu, Chenglu Mao, Yue Cheng, Hao Zhang, Yun Zhang, Xiaolei Zhu, Yun Xu

ePub

14.05.2026

Zhiyi Wu, Qinglong Tan, Fei Xue, Zhuotong Jiang, Hongyu Zhao, Yuting Zhang, Yiming Liu, Yu Zhang, Danli Ding, Hongping Chen, Yingqi Xu, Feng Li, Chunlong Zhang

ePub

13.05.2026

Léa Renard, Clément Aveneau, Karl Götze, Olivier Varnet, Alice Dieudonné, Claire Hourrègue, Emmanuel Cognat, Julien Dumurgier, Capucine Diard, Marie-Pia d’Ortho, Claire Paquet, Agathe Vrillon

ePub

12.05.2026

Zhi Zhou, Jin Gao, Qi Wang, Qigeng Wang, Linwen Liu, Xiaojun Zhang, Can Li, Jiajin Liu, Yidan Wei, Shixiang Zhang, Ruimin Wang, Jianping Jia, Liping Fu

ePub

08.05.2026

Byung-Joon Ko, Yong-Moon Mark Park, Kyu-Na Lee, Kyungdo Han, Ga Eun Nam

ePub

08.05.2026

Aina Comas-Albertí, Albert Lladó, Diana Esteller-Gauxax, Sergi Borrego-Écija, Neus Falgàs, Farida Dakterzada, Agnès Pérez-Millan, Roger Puey, Tània Collet-Romà, Núria Guillén, Miquel Massons, Adrià Tort-Merino, Josep Maria Augé, Guadalupe Fernandez-Villullas, Bea Bosch, Raquel Ruiz-García, Laura Naranjo, Mircea Balasa, Gerard Piñol-Ripoll, Anna Antonell, Raquel Sánchez-Valle

ePub

07.05.2026 · 1 Zitationen

Rawan Tarawneh, Krista L. Moulder, Danai G. Topouza, Amrita Kar, Heng Tony Qian, Vernon S. Pankratz, Jigyasha Timsina, Erin E. Franklin, Suzanne E. Schindler, Richard J. Perrin, Beau M. Ances, Tammie L.S. Benzinger, Jason Hassenstab, John C. Morris, David M. Holtzman, Carlos Cruchaga

ePub

07.05.2026 · 2 Zitationen

Krystal K. Laing, Nela Fialova, Joanna Wardlaw, Axel Montagne

Abstract Background The E4 variant of Apolipoprotein E (APOE) is a primary genetic susceptibility risk factor for late-onset Alzheimer’s disease and has been implicated in cerebrovascular dysfunction. Preclinical mouse models are widely used to study APOE4, but cohesive understan …

ePub

02.05.2026

Ahmad Allouche, Julie Colin, Catherine Birck, Henri Schroeder, Valentin Tallandier, Marion Baldoni, Christophe Muller, Mohamed Afrassi, Nicolas Violle

ePub

01.05.2026

Daniele Urso, Alessandra Vitulli, Stefano Giannoni-Luza, Valentina Gnoni, Alessia Giugno, Eleonora Rollo, Davide Vilella, Chiara Zecca, Nicolas Ray, Giancarlo Logroscino

ePub

01.05.2026

Ramya Burra, Palash K. Malo, Hitesh Pradhan, Raghav Prasad, Pooja Rai, Thomas G. Issac, Jonas S. Sundarakumar, Siva Athreya, Rajesh Sundaresan, CBR-SANSCOG Study Team, CBR-TLSA Study Team

ePub

29.04.2026

Dan Yang, Zhihong Ke, Nihong Chen, Ling Yue, Shuai Chen, Maoyuan Jiang, Zheqi Hu, Chunming Xie, Wenhao Zhu, Jingxian Xu, Linjie Yu, Limoran Tang, Hui Zhao, Jingde Dong, Chaosheng Li, Guofang Chen, Benyan Luo, Jiewen Zhang, Yun Xu

ePub

28.04.2026 · 1 Zitationen

Daniel Andrews, Shirin Golchi, D. Louis Collins, for the Alzheimer’s Disease Neuroimaging Initiative

ePub

28.04.2026

Su Jin Chung, Minwoong Kang, Yu Jeong Park, Kyungmi Oh, Seong-Beom Koh, Sung Hoon Kang

ePub

28.04.2026 · 1 Zitationen

Martin Torp Rahbek, Helene Kildegaard, Jesper Hallas, Martin Thomsen Ernst, Lars Christian Lund

ePub

28.04.2026

Yue Zhang, Qilong Tan, Songtao Wu, Xiaolin Xu

ePub

27.04.2026

Damien Gallagher, Yejin Kang, Nathan Herrmann, Alex Kiss, Sandra E. Black, Paul Oh, Susan Marzolini, Jennifer S. Rabin, Ana Andreazza, Joel Ramirez, Fuqiang Gao, Mark Rapoport, Jinghan Jenny Chen, Kate Survilla, Danielle Vieira, Ethan Mah, Walter Swardfager, Krista L. Lanctôt

ePub

25.04.2026

Yanlu Huang, Qiong Gong, Zhuoyi Zhong, Qihao Guo

ePub

25.04.2026

Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Australian Imaging Biomarkers and Lifestyle Study, Alzheimer’s Disease Neuroimaging Initiative, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai

ePub

24.04.2026 · 1 Zitationen

Hanna Boscheck, Maxie Luft, René Mauer, Selin Senguel, Ylenia D’elia, Peter Dechent, Klaus Fliessbach, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Marie Kronmüller, Falk Lüsebrink, Lukas Preis, Boris Rauchmann, Ayda Rostamzadeh, Björn Hendrik Schott, Sebastian Sodenkamp, Eike Spruth, Sophia Stoecklein, Renat Yakupov, Gabriel Ziegler, Frederic Brosseron, Katharina Buerger, Julian Hellmann-Regen, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Stefan Teipel, Jens Wiltfang, Frank Jessen, Emrah Düzel, Sandra Röske, Michael Wagner, Franka Glöckner

Abstract Background Potentially modifiable lifestyle and psychological factors may influence Alzheimer’s disease (AD)-related brain pathology and cognitive function, thereby influencing cognitive resilience in late life. Objective This cross-sectional study investigated associati …

ePub

24.04.2026

Ben Chen, Pengbo Gao, Huanmin Liu, Danyan Xu, Qiang Wang, Mingfeng Yang, Haoye Tan, Zhidai Xiao, Shihan Tian, Zihan Wang, Youxuan Zheng, Xiaomin Zheng, Shuang Liang, Qin Liu, Jiafu Li, Xiaomei Zhong, Yuping Ning

ePub

24.04.2026

Marlies Oosthoek, Sjors G.J.G. In ’t Veld, Lisa Vermunt, Yuanqing Ye, Manon van Ingen, Marleen Koel-Simmelink, Everard G.B. Vijverberg, Satya Saxena, Steven Hersch, Michael Irizarry, Pallavi Sachdev, Charlotte E. Teunissen

ePub

22.04.2026

Siqi Xie, Yumei Liang, Yana Pang, Ying Li, Shuman Cao, Yan Li, Qi Wang, Abhay Moghekar, Marilyn Albert, Jianping Jia, BIOCARD Study team, Barbara Rodzon, Anja Soldan, Corinne Pettigrew, Leonie Farrington, Maura Grega, Michael Miller, Susumu Mori, Tilak Ratnanather, Anthony Kolasny, Hanzhang Lu, Kenichi Oishi, Laurent Younes, Sara Grace Ho, David Shade, Ann Ervin, Jennifer Jones, Hamadou Coulibaly, Mei-Cheng Wang, Yuxin Zhu, Jiangxia Wang, Juan Troncoso, David Nauen

ePub

21.04.2026

Caitlin M. Terao, Fareshte Erani, Uriel Urias, Francesca Lopez, Fini Chang, Sarah J. Banks, Paul E. Gilbert, David G. Coughlin, Katherine J. Bangen, Kelsey R. Thomas

ePub

20.04.2026

Zhiyan Chen, Yadi Liu, Huan Wang, Ke Liu, Yutong Li, Xiaohua Hu, Rui Li, Linjuan Sun

Abstract Objective Because the clinical diagnosis of Alzheimer’s disease (AD) still relies largely on cognitive decline and A/T/N biomarkers remain costly and invasive, we aimed to identify literature-derived serum microRNAs (miRNAs) associated with cognitive function in AD and t …

ePub

20.04.2026

Kazuya Kawabata, Sayuri Shima, Reiko Ohdake, Epifanio Bagarinao, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike, Atsushi Kasai, Akihiro Ueda, Mizuki Ito, Junichi Hata, Shinsuke Ishigaki, Hiroshi Toyama, Takahiko Tokuda, Akihiko Takashima, Hirohisa Watanabe

Abstract Background Path integration (PI) is a navigational computation that can be affected by aging and Alzheimer’s disease (AD). Virtual-reality PI (VR-PI) preferentially engages medial temporal circuits and can reveal subtle changes that occur prior to overt impairment. Never …

ePub

20.04.2026

Juan Castilla-Silgado, Sergio Perez-Oliveira, Paola Pinto-Hernandez, Manuel Fernandez-Sanjurjo, Maria Daniela Corte-Torres, Olaya Fernandez-Alvarez, Eduardo Iglesias-Gutierrez, Manuel Menendez-Gonzalez, Victoria Alvarez, Cristina Tomas-Zapico

ePub

18.04.2026 · 1 Zitationen

Ziyu Zhang, Chengdong Xu

ePub

18.04.2026

Weiran Zheng, Duyan Geng, Alan Wang, Zhichao Li, Aoge Liu, Shuting Chen, Qiang Wang, Chi Su, Ziyi Yan, Yue Yin, Guizhi Xu

Abstract Background The normal functioning of gamma rhythms is crucial for maintaining brain health, while their abnormalities are closely associated with various neurological disorders, particularly Alzheimer’s disease. Gamma stimulation modalities including auditory, visual, el …

ePub

17.04.2026

Núria Tort-Colet, Laura Stankeviciute, Ana Fernández-Arcos, Natalia Soldevila-Domenech, Gonzalo Sánchez-Benavides, Mahnaz Shekari, David Vállez García, Daniele Altomare, Frederik Barkhof, Mercè Boada, Christopher Buckley, Lyduine E. Collij, Anouk den Braber, Gill Farrar, Lisa Ford, Giovanni B. Frisoni, Rossella Gismondi, Juan D. Gispert, Sylke Grootoonk, Bernard J. Hanseeuw, Frank Jessen, Emma S. Luckett, Richard Manber, Marta Marquié, Anja Mett, Lisa Quenon, Craig Ritchie, Mark E. Schmidt, Michael Schöll, Andrew W. Stephens, Rik Vandenberghe, Pieter J. Visser, Robin Wolz, Oriol Grau-Rivera, the AMYPAD Consortium

ePub

15.04.2026

Chunyan Li, Jiafeng Wang, Ziwei Chen, Xiaodong Han, Cuicui Liu, Huisi Zhang, Jie Lu, Yifei Ren, Tao Gong, Yan Wang, Xiaoyu Wang, Qianqian Xie, Tingting Hou, Yongxiang Wang, Lin Cong, Grégoria Kalpouzos, Lin Song, Yifeng Du, Chengxuan Qiu

ePub

14.04.2026

Courtney H. Van Houtven, Cassie B. Ford, Elyse Couch, Megan Shepherd-Banigan, Wenhan Zhang, Emmanuelle Bélanger, Brenda L. Plassman, James R. Burke, Corinna Sorenson, Nicole DePasquale, Emily O’Brien, Eric Jutkowitz, Terrie Wetle, Valerie A. Smith

Abstract Background To explore the relationship between receipt of amyloid-β PET scan results and subsequent experiences of economic strain and financial decision-making for persons with cognitive impairment and their care partners. Methods A parallel convergent mixed-methods des …

ePub

11.04.2026

Sadaqa Zehra, Sanskriti Rai, Komal Rani, Saumitra Dey Choudhury, Himanshu Rai, Suchismita Bhowmik, Nitin Mohan, Anu Gupta, Prasun Chatterjee, Thota Jagadeshwar Reddy, Neerja Rani, Gyan Prakash Modi, Fredrik Nikolajeff, Saroj Kumar

Abstract While small extracellular vesicles (sEVs) are implicated in amyloid-β trafficking, the mechanisms governing their interaction with Aβ aggregates and plaque formation remain unresolved. Here, we report a sEVs undergo dynamic structural remodelling in response to stress, e …

ePub

11.04.2026

Jun Ki Yoo, Ju Han Kim

ePub

10.04.2026 · 2 Zitationen

Erica Andreozzi, Takuya Yagi, Kristin Wildsmith, Sumit Rawal, Kanta Horie, Peter Boyd, Eri Takahashi, Nicolas R. Barthélemy, Jagadeesh Aluri, Arnaud Charil, Anthonin Reilhac, Brian A. Gordon, Shaney Flores, David Verbel, Nicholas Sauter, Tammie L. S. Benzinger, Eric McDade, Catherine Mummery, Dominantly Inherited Alzheimer Network (DIAN), Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), Jin Zhou, Randall J. Bateman, Larisa Reyderman

ePub

10.04.2026

Leonardino A. Digma, Christina B. Young, Joseph R. Winer, Karly A. Cody, Kyan Younes, Jintao Sheng, Philip S. Insel, Robert A. Rissman, Reisa Sperling, Elizabeth C. Mormino

Abstract Background Biological Staging for Alzheimer’s disease (AD) in clinically unimpaired (CU) individuals is critical for early detection efforts. In this study, we evaluated whether Core 1 biomarkers (plasma p-tau217 and amyloid-PET) within Biological Stage A, the earliest b …

ePub

09.04.2026

Daniele Urso, Jeremy Ting, Elena Davison, Stefano Giannoni-Luza, Linh Bui, Giancarlo Logroscino

ePub

06.04.2026 · 1 Zitationen

Valentina Di Caro, Eunah Cho, Jill Thiel, Britney N. Lizama, Marleen J.A. Koel-Simmelink, Kiran Pandey, Duc Duong, Nicholas T. Seyfried, Michael Grundman, Charlotte E. Teunissen, Henrik Zetterberg, Kaj Blennow, Anthony O. Caggiano, Mary E. Hamby

Abstract Background Zervimesine (CT1812) is an investigational brain-penetrant small molecule modulator of the sigma-2 receptor (S2R/ TMEM97 ), currently in clinical development for the treatment of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) that selectively pre …

ePub

06.04.2026

Ling-Ling Li, Jie Ma, Jia-Jia Wu, Xin Xue, Yi-Yan Sun, Xu-Yun Hua, Qi-Hao Guo, Jian-Guang Xu

ePub

06.04.2026

Laure Spruyt, Tjaša Mlinarič, Nathalie Dusart, Mariska Reinartz, Marc M. Van Hulle, Stefan Sunaert, Koen Van Laere, Patrick Dupont, Rik Vandenberghe

ePub

01.04.2026

Francesca Natale, Alice Dellaria, Ida Nifo Sarrapochiello, Lucia Leone, Matteo Spinelli, Marco Rinaudo, Nicoletta Garofalo, Claudio Grassi, Salvatore Fusco

ePub

01.04.2026 · 1 Zitationen

Miao Fang, Yibing Yan, Wenqian Song, Zhi Geng, Lu Wang, Chenyang Hu, Weiqiang Li, Bo Song, Mengdan Chen, Yulong Dai, Yifan Hu, Shanshan Zhou, Haihua Guo, Gongjun Ji, Panpan Hu, Kai Wang, Xingqi Wu

ePub

01.04.2026

Zan Wang, Dandan Liu, Xueli Cai, Yingying Yang, Xinya Zheng, Guanyu Niu, Jing Jing, Yongjun Wang, Yuesong Pan, Yilong Wang

ePub

31.03.2026

Julius Opwonya, Boncho Ku, Frank van der Heide, Kun Ho Lee, Joong Il Kim, Jaeuk U. Kim

ePub

31.03.2026

Andy Delgado, Kanisa Davidson, Danitra Parker, JaLeesa Bryant, Vicki Winstead, Mustafa Yildiz, Carolyn E.Z. Pickering, Andrew M. Pickering

ePub

30.03.2026 · 2 Zitationen

Dario Bachmann, Christoph Gericke, Maha Wybitul, Antje Saake, Sandro Studer, Katrin Rauen, Esmeralda Gruber, Andreas Buchmann, Martin Hüllner, Kaj Blennow, Henrik Zetterberg, Roger M Nitsch, Christoph Hock, Valerie Treyer, Anton Gietl

ePub

30.03.2026

Hui Zhang, Chongyu Ding, Yaqian Xu, Harong Hao, Yulu Gong, Tongyan An, Zixin Hu, Yi Li, Xiaofeng Wang, Shuai Jiang, Meng Hao, Xiangwei Li

ePub

30.03.2026 · 1 Zitationen

Seung-Jae Kim, Mun-Ju Kim, Jun-Su Kim, Jaeho Jang, Wiha Choi, Hyun-ju Lee, Jeong-Heon Song, Hyang-Sook Hoe

ePub

28.03.2026 · 4 Zitationen

Jonathan Merkel, Robert Perneczky, Frank Jessen, Lutz Frölich, Olav Jansen, Sönke Peters, Daniela Berg, Jörg B. Schulz, Thorsten Bartsch

Abstract Monoclonal antibodies targeting amyloid-β are the first approved disease-modifying treatment for Alzheimer’s disease. While amyloid-targeting therapies mitigate the progression of cognitive decline in early-stage Alzheimer’s disease, they are associated with amyloid-rela …

ePub

27.03.2026

Yanchen Ma, Meng Xie, Carlos F. Ibáñez

Abstract Although protein palmitoylation has been associated with Alzheimer’s Disease (AD), it remains unclear whether or how palmitoylation of specific proteins contributes to any of the pathological features of AD. The p75 neurotrophin receptor (p75 NTR ) contributes to AD prog …

ePub

27.03.2026

Jetske van der Schaar, Wiesje M. van der Flier, Leonie N. C. Visser, Elsmarieke van de Giessen, Argonde C. van Harten, Sietske A. M. Sikkes, Mardou S. S. A. van Leeuwenstijn-Koopman, Heleen M. A. Hendriksen, Calvin Trieu, Annelien L. Bredenoord, Mariette A. van den Hoven, Eva C. A. Asscher

Abstract Background Biomarker assessments increasingly inform the diagnostic evaluation and treatment decisions in Alzheimer disease (AD). However, evidence on the impact of amyloid positron emission tomography (PET) disclosure is primarily derived from studies of cognitively uni …

ePub

27.03.2026 · 1 Zitationen

Ming Li, Qian Yu, Shuyi Yu, Qian Cheng, Shuang Wu, Yan Jin, Zhikang Cui, Hang Chen, Xiaoyi Zhao, Xiaoben Wu, Zhiming Lu

ePub

26.03.2026

Mei Li, Nianzhuang Qiu, Wenhui Niu, Chenliang Qian, Yuqiong Zhang, Wubin Yang, Fengyang Ding, Hao Wang, Xiaoyan Xu, Jie Xia, Xuehui Zhang

ePub

25.03.2026

Neelam Younas, Abrar Younas, Peter Hermann, Leticia Camila Fernandez Flores, Kathrin Dittmar, Saima Zafar, Holger Budde, Tobias J. Legler, Tayyaba Saleem, Matthias Schmitz, Inga Zerr

Abstract Background TIA-1 (T-cell intracellular antigen 1) is an RNA-binding protein central to the formation of stress granules (SGs) and modulation of inflammatory responses. Recent research has identified TIA-1 as a key player in neurodegenerative diseases, especially those in …

ePub

25.03.2026 · 1 Zitationen

Fengting Cao, Jinxi Liu, Hongchun Zuo, Xulian Lin, Yuhong Su, Chang Wang, Huixian Cui, Juan Du, Yizhou Zhang

Abstract Alzheimer’s disease (AD) shows a notable female bias in both prevalence and severity. This bias is closely linked to declining estradiol levels during menopause. Our study demonstrated that estradiol can inhibit the accelerated progression of AD caused by ovariectomy (OV …

ePub

25.03.2026

Naomi Hannaway, Angeliki Zarkali, Rohan Bhome, Ivelina Dobreva, Sabrina Kalam, George E. C. Thomas, Barbara Dymerska, Irene Gorostiaga Belio, Katie Tucker, Amanda Heslegrave, Henrik Zetterberg, Rimona S. Weil

Abstract Background Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are subtypes of Lewy body dementia (LBD) and overlap in symptoms and pathology. Glymphatic function is implicated in LBD pathophysiology due to reduced clearance of abnormal proteins. We ai …

ePub

24.03.2026 · 1 Zitationen

Andrea E. Zülke, Melanie Luppa, Laurenz Lammer, Susanne Röhr, Ronny Baber, Ronald Biemann, Kerstin Wirkner, Samira Zeynalova, Maryam Yahiaoui-Doktor, Silke Zachariae, Christoph Engel, Andreas Hinz, Heide Glaesmer, Matthias L. Schroeter, Markus Löffler, Arno Villringer, A. Veronica Witte, Frauke Beyer, Steffi G. Riedel-Heller

Abstract Background Dementia risk and changes in cognitive performance follow a social gradient, however, evidence on the respective role of socioeconomic status (SES) and lifestyle for cognitive performance is inconclusive. We investigated effects of SES and lifestyle (Lifestyle …

ePub

21.03.2026 · 1 Zitationen

Adriana Gea-González, Renata Valle-Pedroso, Inmaculada López-Font, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero, María-Salud García-Ayllón

ePub

21.03.2026 · 1 Zitationen

Beata Borgström Bolmsjö, Josef Barbosa Djärf, Danielle van Westen, Suzanne E. Schindler, Ayesha Fawad, Lyduine Collij, Ruben Smith, Niklas Mattsson-Carlgren, Erik Stomrud, Pontus Tideman, Oskar Hansson, Sebastian Palmqvist

Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia and a growing healthcare challenge. Amyloid-targeting therapies (ATT) may slow progression, but implementation is limited by logistical and economic barriers. As primary care is the first contact fo …

ePub

20.03.2026 · 5 Zitationen

Federica Agosta, Giordano Cecchetti, Edoardo G. Spinelli, Alma Ghirelli, Giulia Rugarli, Stefano Pisano, Federico Coraglia, Elisa Canu, Veronica Castelnovo, Elisa Sibilla, Anna Gilioli, Chiara Tripodi, Fabiola Freri, Alessandra Bianchi, Paolo Vezzulli, Sonia Calloni, Andrea Falini, Ana Maria Samanes Gajate, Andrea Panzacchi, Gino Pepe, Camilla Ferri, Arturo Chiti, Massimo Filippi

Abstract Background Anti-amyloid monoclonal antibodies are entering clinical practice for early symptomatic Alzheimer’s disease (AD), but European real-world data on feasibility, safety, and biomarker monitoring remain limited. We report the first year of implementation of lecane …

ePub

20.03.2026

Zainab Khurshid, Tong Tong, Oluwatosin Olayinka, John J. Farrell, Congcong Zhu, Alzheimer’s Disease Sequencing Project, Eden R. Martin, William S. Bush, Margaret A. Pericak-Vance, Li-San Wang, Gerard D. Schellenberg, Jonathan L. Haines, Kathryn L. Lunetta, Xiaoling Zhang, Lindsay A. Farrer

ePub

19.03.2026

Jie-Wen Zhang, Rong Li, Yu-Xin Niu, Si-Yuan Liu, Chen-Hong Li, Xiao-Di Hao, Sheng-Hui Wang, Shuai Chen, Feng-Yu Wang

ePub

18.03.2026 · 1 Zitationen

Andrea Valera-Barrero, Francisco Martínez-Dubarbie, Armando Guerra, Sara López-García, Carmen Lage, María Rivera-Sánchez, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Guglielmo Di Molfetta, Kaj Blennow, Nicholas J. Ashton, Henrik Zetterberg, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Marta Fernández-Matarrubia

ePub

17.03.2026 · 1 Zitationen

Jetske van der Schaar, Leonie N. C. Visser, Eva C. A. Asscher, Yolande A. L. Pijnenburg, Christa M. de Geus, Wiesje M. van der Flier, Annelien L. Bredenoord, Mariette A. van den Hoven, Ellen M. A. Smets, Sven J. van der Lee

Abstract Background While memory clinic patients express interest in diagnostic genetic testing for monogenic causes of dementia, its personal consequences remain unclear. We explored the psychosocial and behavioral impact on patients and relatives. Methods In this mixed-methods …

ePub

12.03.2026 · 2 Zitationen

Junjie Wu, Benjamin B. Risk, Taylor A. James, Nicholas T. Seyfried, David W. Loring, Felicia C. Goldstein, Allan I. Levey, James J. Lah, Deqiang Qiu

Abstract Background Non-linear alterations in brain network connectivity may represent early neural signatures of Alzheimer’s disease (AD) pathology in cognitively normal older adults. Understanding these changes and their cognitive relevance may help clarify early network vulner …

ePub

12.03.2026 · 1 Zitationen

Shayan Mostafaei, Daniel Wikström Shemer, Jonathan K. L. Mak, Ida K. Karlsson, Sara Hägg

Abstract Background Alzheimer’s disease and related dementias (ADRD) are complex, polygenic conditions with substantial public health impact. Accurate genetic risk prediction may enable earlier identification and stratification of individuals at elevated risk. Objective To evalua …

ePub

12.03.2026 · 1 Zitationen

Youn Huh, Ga Eun Nam, Kyungdo Han, Jin-Hyung Jung, Bong Seong Kim, Dohee Lee, Hyun Jin Park, Mun Young Yoo, Seo Yeon Yoon, Sung Hoon Kang, Chi Kyung Kim, Seon Mee Kim, Hye Soon Park

ePub

09.03.2026

Andre Mueller, Aleksandar Jovalekic, Marianne Chapleau, Julius Seidel, Maria Ritter, Eva-Maria Bickel, Nadine Kiessling, Emer MacSweeney, Andrew W. Stephens, Norman Koglin

ePub

07.03.2026 · 1 Zitationen

Jingmei Yang, Huitong Ding, Samad Amini, Boran Hao, Cody Karjadi, Rhoda Au, Ioannis Ch. Paschalidis

ePub

06.03.2026 · 2 Zitationen

Andrea Mastrangelo, Serena Caldera, Simone Baiardi, Franco Magliocchetti, Angela Mammana, Matilde Testa, Agustina Ranieri, Edoardo Ruggeri, Giuseppe Mario Bentivenga, Vincenzo Mastrangelo, Nicola Mometto, Caterina Ferri, Alessandro Marti, Mario Santangelo, Marco Longoni, Sara Mazzoli, Annalisa Chiari, Leonardo Biscetti, Sabina Capellari, Piero Parchi

ePub

05.03.2026

Claire J. Cadwallader, Pedro Pinheiro-Chagas, Rowan Saloner, Laura Fenton, Anna M. VandeBunte, May Lin, Albert Pham, Coty Chen, Valentina E. Diaz, Molly Olzinski, Sophia Licata, Lana Callies, Carina Lo, Jessica Buxton, Yann Cobigo, Gil Rabinovici, Joel H. Kramer, Kaitlin B. Casaletto, Emily W. Paolillo

Abstract Background Physical activity is a modifiable lifestyle factor linked to better brain health in older adults, yet the optimal parameters (e.g., frequency, duration), and person-specific interactions (e.g., age, sex), remain unclear. Methods We developed a novel algorithm …

ePub

05.03.2026 · 3 Zitationen

Yi Jayne Tan, Raziyeh Mohammadi, Seyed Ehsan Saffari, Nicole Isabella Tan, Louis SS Lim, Shermine HL Low, Louis CS Tan, Hui Jin Chiew, Kok Pin Ng, Shahul Hameed, Simon KS Ting, Adeline SL Ng

ePub

04.03.2026 · 2 Zitationen

Elijah Mak, Scott A. Przybelski, Robert I. Reid, Heather J. Wiste, Angela J. Fought, Christopher G. Schwarz, Matthew L. Senjem, Prashanthi Vemuri, Clifford R. Jack, Val J. Lowe, Ronald C. Petersen, Bradley F. Boeve, Kejal Kantarci, Alzheimer’s Disease Neuroimaging Initiative

ePub

03.03.2026

Heewon Shin, Sunhee Lee, Wonbin Seo, Seok Hyun Yoon, Illhwan Cho, Suhyun Ye, InWook Park, Soljee Yoon, MinSeol Park, Sunghyun Kim, Songmin Lee, Hye Yun Kim, Ikyon Kim, YoungSoo Kim

ePub

03.03.2026 · 2 Zitationen

Takanobu Ishiguro, Masanori Kurihara, Yoichiro Nishida, Emiko Kikkawa-Saito, Kensaku Kasuga, Naoto Takenoshita, Satomi Kubota, Yasuko Kuroha, Kenji Ishii, Meiko Hamada, Nobuo Sanjo, Kinya Ishikawa, Hisashi Nojima, Jo Kamada, Katsumi Aoyagi, Soichiro Shimizu, Hidetomo Murakami, Tetsuya Takahashi, Osamu Onodera, Takeshi Iwatsubo, Masahito Yamada, Takanori Yokota, Atsushi Iwata, Takeshi Ikeuchi

ePub

28.02.2026 · 2 Zitationen

Bon Gook Koo, Ha-Eun Seo, Yejin Yun, Daegyeom Kim, Jae Myeong Kang, Jaelim Cho, Sang-Yoon Lee, Yu Joo Lee, Kee Hyung Park, Min Jae Lee, Young Noh

ePub

28.02.2026 · 1 Zitationen

Jochen Titeca, Marta Scarioni, Matthijs Oyaert, Tim Van Langenhove

ePub

27.02.2026 · 2 Zitationen

Nelsan Pourhadi, Christina Jensen-Dahm, Thomas Munk Laursen, Christiane Gasse, Gunhild Waldemar, Janet Janbek

ePub

25.02.2026 · 1 Zitationen

M. Matos, A. Oliveira, I. Matias, A. Le Boulch, P. Ciofi, L. Dupuy, E. Huc, S. H. R. Oliet, A. Panatier

ePub

24.02.2026

Qingyue Li, Zampeta-Sofia Alexopoulou, Martin Dyrba, Elisa Mallick, Johannes Tröger, Eike Spruth, Slawek Altenstein, Claudia Bartels, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Ingo Kilimann, Sebastian Sodenkamp, Franziska Maier, Ayda Rostamzadeh, Antje Osterrath, Josef Priller, Anja Schneider, Jens Wiltfang, Christoph Laske, Björn Falkenburger, Michael Wagner, Emrah Duezel, Annika Spottke, Gabor C. Petzold, Frank Jessen, Alexandra König, Stefanie Köhler, Stefan Teipel, DELCODE, DESCRIBE study groups

Abstract Background Digital speech-based assessments provide scalable tools for detecting subtle cognitive decline. Here, we investigated whether digitally derived speech-based composite score of cognition and individual speech features were associated with alterations in functio …

ePub

24.02.2026

Wanwan Guo, Hongda Shao, Yan Zhang, Lin Liu, Hairong Zheng, Dong Liang, Jianjun Liu, Lingyan Zhang, Zhanli Hu

ePub

20.02.2026

Maria Anna Papadopoulou, Konstantina Chanoumidou, Maria Peteinareli, Electra Tsaglioti, Konstantina Michalaki, Matthieu D. Lavigne, Ioannis Charalampopoulos

ePub

19.02.2026 · 1 Zitationen

Mikko Koivumäki, Henna Martiskainen, Mari Takalo, Jenni Lehtisalo, Tiia Ngandu, FinnGen, Anniina Snellman, Mikko Hiltunen, Juha O. Rinne

Abstract Background Alzheimer’s disease (AD) has a strong genetic component, with APOE ε4 being the most established risk factor through its effects on beta-amyloid (Aβ) metabolism and microglial function. Recent genetic studies have also implicated microglial genes, such as the …

ePub

19.02.2026 · 1 Zitationen

Lifang Lv, Yuhan Jia, Chi Zhang, Qiang Gao, Huiming Han, Jiaxin Li, Zhenhua Cai, Meiqi Liu, Ying Zhang, Jinfeng Liu, Hui Zhu

Abstract Background Ferroptosis has been implicated in the pathogenesis of Alzheimer’s disease (AD), yet its upstream neuronal regulators remain unclear. This study investigated the mechanisms by which melatonin exerts neuroprotection, focusing on the glutamine transporter solute …

ePub

19.02.2026 · 9 Zitationen

Binghua Wang, Miaomiao Pan, Liu Yang, Jietian Xu, Chang Ye, Yunhan Li, Qianyi Gong, Changqian Liu, Lanfang Li, Jie Qin, Dayong Ren, Chao Zhao, Chunmin Liang

ePub

16.02.2026

Jiajia Zhang, Xuejia Jia, Haibin Li, Xiuqin Jia, Qi Yang

ePub

14.02.2026

Lewis K. Penny, Mohammad Arastoo, Richard Lofthouse, Aya Abdallah, Peter I. Imoesi, Karima Schwab, Helen Shiells, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik, Andrew Porter, Soumya Palliyil

Abstract Introduction Immunotherapy is an attractive proposition for preventing the spread of pathologic tau in Alzheimer’s disease and other tauopathies. Given that tau is heavily truncated in tauopathies, it is hypothesised that directly targeting the repeat domain which forms …

ePub

14.02.2026

Paulina Orellana, Fernando Henríquez, Felipe Cabral-Miranda, Hernán Hernandez, Pamela C L Ferreira, Bruna Bellaver, Ariel Caviedes, Matias Pizarro, Carolina Gonzalez-Silva, Nickole Marin-Diaz, Patricio Riquelme, Natalia Pozo, Francisca Damm, Felipe A. Court, Christian Gonzalez-Billault, Patricia Lillo, Daniela Thumala-Dockendorff, Mauricio Cerda, Roque Villagra, Rolando de la Cruz, Thomas Karikari, Agustín Ibañez, Henrik Zetterberg, Tharick A Pascoal, Claudia Duran-Aniotz, Andrea Slachevsky

ePub

11.02.2026

Patrick Oeckl, Samir Abu-Rumeileh, Christopher M. Weise, Markus Otto, Alzheimer’s Disease Neuroimaging Initiative

Abstract Background β-Synuclein is an emerging synaptic blood biomarker for Alzheimer´s disease (AD) and correlates with cognitive impairment, brain atrophy and amyloid/tau pathology. Longitudinal data from individual patients are missing so far but are important to evaluate how …

ePub

11.02.2026 · 2 Zitationen

Yanaika S. Hok-A-Hin, Bram Bongers, Katharina Bolsewig, Lynn Boonkamp, Daimy N. Ruiters, Afina W. Lemstra, Wiesje M. van der Flier, Yolande A.L. Pijnenburg, Marta del Campo, Charlotte E. Teunissen

ePub

10.02.2026 · 2 Zitationen

Alessandro Zilioli, Rosaleena Mohanty, Anna Rosenberg, Anna Matton, Tobias Granberg, Göran Hagman, Marco Spallazzi, Daniel Ferreira, Miia Kivipelto, Eric Westman

Abstract Background Brain atrophy subtypes are increasingly recognized in Alzheimer’s disease (AD) dementia. However, their relevance across the real-world memory clinic spectrum, from subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) to AD and non-AD deme …

ePub

10.02.2026 · 1 Zitationen

Gao-shang Chai, Tian-long Gao, Shu-guang Bi, Yu-ming Mao, Liu Yang, Fang-zhou Wang, Jia Chen, Jia-jun Wu, Juan Gong, Shan Geng, Jia-qi Yuan, Ke-yu Zhang, Hai-yan Yi, Zi-chong Lan, Yun-juan Nie, Haitao Yu

Abstract Background Physical activity (PA) is strongly associated with enhanced cognitive resilience and a lower risk of Alzheimer’s disease (AD) in the aging population. However, the molecular mechanisms linking exercise-induced neuroprotection to epigenetic remodeling remain po …

ePub

10.02.2026

Kok Pin Ng, Joanna Su Xian Chong, Firoza Lussier, Joseph Therriault, Nesrine Rahmouni, Melissa Savard, Jenna Stevenson, Tharick Pascoal, Serge Gauthier, Pedro Rosa-Neto, Juan Helen Zhou

ePub

07.02.2026 · 4 Zitationen

Wenyan Lu, Keiji Kawatani, Yingxue Ren, Toshihiko Nambara, Lin Jia, Suren Jeevaratnam, Eunmi Lee, Paula Rodriguez Martinez, Taha Izhar, Ni Wang, Ana-Caroline Raulin, Zbigniew K. Wszolek, Guojun Bu, Takahisa Kanekiyo, Yonghe Li

ePub

06.02.2026 · 1 Zitationen

Sinthujah Vigneswaran, Inge M.W. Verberk, Rebecca Z. Rousset, Mariam Gouda, Calvin Trieu, Thomas Claessen, Elsmarieke van de Giessen, Afina W. Lemstra, David Wilson, Yolande A.L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Argonde C. van Harten

ePub

06.02.2026

Thanos Tsaktanis, Laura Rudtke, Leander Ammon, Stefan Mestermann, Veit Rothhammer, Piotr Lewczuk, Juan Manuel Maler, Johannes Kornhuber, Timo Jan Oberstein

Abstract Background The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor linking environmental signals to immune regulation and neurodegeneration. While AHR agonists exert protective effects in Alzheimer’s disease (AD) models, their relevance in humans r …

ePub

06.02.2026 · 1 Zitationen

Rebecca A. Deek, Wasiu G. Balogun, Xuemei Zeng, Gallen Triana-Baltzer, Tharick A. Pascoal, Hartmuth C. Kolb, Beth Snitz, Ann D. Cohen, Thomas K. Karikari

ePub

05.02.2026 · 3 Zitationen

Jianhong Xiao, Yi Liu, Mingli Peng, Jiaying Ma, Shujing Lei, Yuexuan Chen, Shanshan Liu, Xibao Zhao, Desheng Lu, Qi Sun

Abstract Background Defective Wnt/β-catenin signaling is closely associated with the pathogenesis of Alzheimer’s disease (AD), thus validating this pathway as a therapeutic target for AD. ISX9 is a potent agonist of the Wnt/β-catenin pathway. However, it remains unknown whether I …

ePub

04.02.2026

Liwei Ma, Yihan Wang, Benjamin Goudey, Liang Jin, Yijun Pan

ePub

04.02.2026 · 2 Zitationen

Federico Bellelli, Julien Delrieu, Gabor Abellan van Kan, Alberta Peluso, Gaëlle Soriano, Bruno Vellas, Davide Angioni, Sandrine Sourdet

Abstract Background Following the positive outcomes of the Clarity-AD trial, Lecanemab received marketing authorization from the European Medicines Agency (EMA) and is expected to become available across Europe. However, the trial did not specifically evaluate frailty, making it …

ePub

02.02.2026 · 6 Zitationen

Lorenzo Gaetani, Giovanni Bellomo, Giovanna Nardi, Andrea Toja, Carla Streva, Erica Giombetti, Edoardo Guido Torrigiani, Federico Paolini Paoletti, Alfredo Villa, Alessandro Tozzi, Davide Chiasserini, Lucilla Parnetti

ePub

02.02.2026

Ana C. Valencia-Olvera, Felecia M Marottoli, Kiira Ratia, Gregory RJ Thatcher, Leon Maing Tai

Abstract Background Published data suggest that compared to APOE3 , APOE4 could increase the risk of neurodegeneration via higher cerebrovascular permeability. We recently proposed the concept that brain endothelial cell APOE is protective for cerebrovascular function in a genoty …

ePub

31.01.2026 · 1 Zitationen

Heli Jeskanen, Sami Heikkinen, Inka Kervinen, Jenni Lehtisalo, Tiia Ngandu, Roosa-Maria Willman, Jessica Rosa, Dorit Hoffmann, FinnGen, Ville Leinonen, Annakaisa Haapasalo, Mari Takalo, Henna Martiskainen, Mikko Hiltunen

Abstract Background The PLCG2 -P522R variant, which encodes a mildly hyperactive form of the PLCγ2 enzyme, has been identified as a protective genetic factor against Alzheimer’s disease (AD). Many recently discovered AD-associated microglial risk genes converge on the TREM2-PLCγ2 …

ePub

31.01.2026 · 1 Zitationen

Sean Paz, Janet D. Robishaw, Massimo Caputi

ePub

31.01.2026

Linn Öijerstedt, Sára Mravinacová, Jennie Olofsson, Louisa Azizi, Sofia Bergström, Solmaz Yazdani, Nina De Vita, Inci S. Aksoylu, Juliette Foucher, Alexander Juto, Ulf Kläppe, Peter Nilsson, Anna Månberg, Caroline Ingre

Abstract Background Cognitive impairment is a recognised feature of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Despite advances in understanding cognitive impairment in ALS, no fluid biomarkers reliably predict these changes. Prior research in Alzh …

ePub

30.01.2026

Yuting Mo, Chenglu Mao, Jialiu Jiang, Shuang Fang, Lili Huang, Zhihong Ke, Zheqi Hu, Dan Yang, Pei Xie, Ruozhu Xiong, Yun Xu

ePub

30.01.2026 · 1 Zitationen

Anshuman Swain, Narayan Datt Soni, Ryan B. Gaspar, James G. Davis, Fang Liu, Halvor Juul, Ravi Prakash Reddy Nanga, Joseph A. Baur, Ravinder Reddy

ePub

29.01.2026 · 4 Zitationen

Sung Hoon Kang, Seongmi Kim, Young Ju Kim, Heejin Yoo, Eun Hye Lee, Hyemin Jang, Daeun Shin, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L. Na, Henrick Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Theresa A. Day, Marco Duering, Seong-Beom Koh, Sang-Young Kim, Eung Yeop Kim, Sung Tae Kim, Beomseok Sohn, Sang Won Seo

ePub

29.01.2026 · 1 Zitationen

Wenying Zou, Leung-Wah Yick, Jason Shing-Cheong Kwan, Zifei Zhang, Huiwen Xue, Koon Ho Chan

ePub

27.01.2026 · 2 Zitationen

Jacqueline Chua, Suman Singh, Shiyuan Gong, Damon Wong, Bingyao Tan, An Qi Toh, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Joyce R. Chong, Mitchell K. P. Lai, Christopher Li-Hsian Chen, Leopold Schmetterer

ePub

26.01.2026 · 1 Zitationen

William Robert Kwapong, Jiahui Chen, Zheli Chen, Chunwen Zheng, Yimo Guo, Yuntao Liu, Haoran Cheng, Huihua Qiu, Xiaoqian Luan, Ip Yiu Ming Bonaventure, Carol Y. Cheung, Zhen Wang

ePub

24.01.2026 · 6 Zitationen

Xiaoduo Liu, Tao Wei, Bo Zhao, Shaojiong Zhou, Lei Liu, Yi Tang

ePub

23.01.2026

Seunghoon Lee, Min Soo Byun, Dahyun Yi, Hyejin Ahn, Gijung Jung, Joon Hyung Jung, Yoon Young Chang, Kyungtae Kim, Hyeji Choi, Jeongmin Choi, Jun‑Young Lee, Koung Mi Kang, Chul‑Ho Sohn, Yun‑Sang Lee, Yu Kyeong Kim, Dong Young Lee, KBASE Research Group

ePub

23.01.2026

Munira Kashem, Olivia Haldenby, Juwairiya Fatima Ahmad, Arshaan Asim Muhammad, Cyprian M. Mostert, Shehzad Ali

ePub

22.01.2026 · 1 Zitationen

Karl Götze, Agathe Vrillon, Manuel Sanchez, Inès Petit-Damico, Elodie Bouaziz-Amar, Sophie Lacaille, Claire Hourrègue, Emmanuel Cognat, Jacques Hugon, Théodore Decaix, Julien Dumurgier, Agathe Raynaud-Simon, Matthieu Lilamand, Claire Paquet

ePub

20.01.2026 · 1 Zitationen

Mihály Unoka, Dalida Borbála Berente-Kerestély, Melinda Becske, Andras Attila Horvath

Abstract Background Verbal fluency (VF) measures are sensitive markers of advanced cognitive decline; however, the utility of the discrepancy score remains underexplored in the early stages of cognitive decline, such as subjective cognitive decline (SCD). This study evaluated sem …

ePub

20.01.2026

Chunyan Ma, Yutong Ye, Xinyu Shi, Na Li, Zhiming Mu, Tao Tan, Huijuan Yin, Jianwu Dai, Yi Liu, Hongli Chen

ePub

19.01.2026 · 2 Zitationen

Dorsa Abdolkarimi, Yue Liu, Lachlan Gilchrist, Sara Calhas, Sheena Waters, Charles R. Marshall, Petroula Proitsi

Abstract Introduction Systemic inflammation has been identified as a key factor in neurodegeneration but the value of circulating inflammatory proteins in dementia risk prediction and their causal role has not been elucidated. Methods We leveraged proteomic data from 43,685 UK Bi …

ePub

16.01.2026 · 4 Zitationen

Yan Zhang, Fuqiang Zhang, Hanlan Yin, Yiyang Sun, Yuxiang Wang, Zhichao Ren, Jinlan Jiang, Linlin Zeng

ePub

14.01.2026 · 1 Zitationen

Heekyoung Kang, Yuna Gu, Jungah Lee, Soyeon Yoon, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Theresa A. Day, Michael W. Weiner, Daeun Shin, Sohyun Yim, Seonghyeon Kim, Hee Kyung Park, Min Young Chun, Eun Hye Lee, Jun Pyo Kim, Hee Jin Kim, Duk L. Na, Hyemin Jang, Sang Won Seo, for the ADNI and K-ROAD study group

Abstract Background We aimed to evaluate whether double cutoff strategies for plasma pTau217 across multiple assay platforms improve tau PET positivity prediction compared with single cutoffs and support cost-effective clinical use. Methods We analyzed two cohorts: K-ROAD ( n = 1 …

ePub

13.01.2026 · 3 Zitationen

Christian Weber, Daniel Wind, Patrick Petzsch, Tillmann Supprian, Alexander Dilthey, Julia Christl, Patrick Finzer

Abstract Background The oral microbiota has been associated with Alzheimer's disease (AD). However, earlier studies provided conflicting results using varying sampling methods, sequencing techniques, and statistics, as well as independent subjects. Methods To robustly identify di …

ePub

12.01.2026 · 1 Zitationen

Hongli Chen, Na Li, Na Liu, Hongyu Zhu, Chunyan Ma, Yutong Ye, Xinyu Shi, Guoshuai Luo, Xiaoxi Dong, Tao Tan, Xunbin Wei, Huijuan Yin

ePub

10.01.2026 · 2 Zitationen

Chenhui Mao, Wenjun Wang, Xinying Huang, Meiqi Wu, Yifei Wang, Tianyi Wang, Yuyue Qiu, Shanshan Chu, Wei Jin, Yuhan Jiang, Jialu Bao, Yunfan You, Yuanheng Li, Liling Dong, Feng Feng, Li Huo, Ling Qiu, Jing Gao

ePub

09.01.2026 · 5 Zitationen

Julia R. Bacci, Stamatia Karagianni, Zampeta-Sofia Alexopoulou, Shirine Moukaled, Claudia Tato-Fernández, Prithvi Arunachalam, Aram Aslanyan, Sandar Aye, Ana Sabsil Lopez Rocha, Monica Crugel, Ayesha Fawad, Aitana Sogorb-Esteve, Michael Schöll, Alexandra König, Ross W. Paterson

ePub

09.01.2026 · 2 Zitationen

Maria A. Altahona-Medina, Marina Fernandez-Alvarez, Karel M. Lopez-Vilaret, Michael D. Rugg, Jose L. Cantero, Mercedes Atienza

ePub

08.01.2026 · 4 Zitationen

Tjaša Mlinarič, Laure Spruyt, Elvira Khachatryan, Benjamin Wittevrongel, Mariska Reinartz, Koen Van Laere, Patrick Dupont, Rik Vandenberghe, Marc M. Van Hulle

ePub

08.01.2026

Dehao Yang, Shiyue Wang, Yangguang Lu, Jinrong Zhu, Jiaxuan Chen, Bo Zhang, Hejia Cai, Bingxin Teng, Ruting Wei, Zhidong Cen, Wei Luo

ePub

08.01.2026 · 2 Zitationen

V. van Gils, L. Waterink, S. C. P. M. Wimmers, J. G. M. Jelsma, M. E. de Vugt, R. Handels, S. A. M. Sikkes, W. M. van der Flier, K. Deckers, M. D. Zwan, S. Köhler, N. Janssen

Abstract Introduction Dementia risk reduction through lifestyle modification has much potential but is not yet implemented in routine clinical care. Currently, there are no preventive interventions available for memory clinic patients. Therefore, the aim of The Lifestyle Interven …

ePub

07.01.2026 · 1 Zitationen

Jang-Han Bae, Minho Choi, Kun Ho Lee, Jaeuk U. Kim

ePub

07.01.2026 · 1 Zitationen

Kamil Borkowski, Chunyuan Yin, Alida Kindt, Nuanyi Liang, Elizabeth de Lange, Colette Blach, John W. Newman, Rima Kaddurah-Daouk, Thomas Hankemeier, the Alzheimer’s Disease Neuroimaging Initiative

Abstract Mounting evidence implicates inflammation as a key factor in Alzheimer’s disease (AD) development. We previously identified pro-inflammatory soluble epoxide hydrolase (sEH) metabolites to be elevated in plasma and CSF of AD participants and to be associated with lower co …

ePub

06.01.2026 · 3 Zitationen

Viviana Brembati, Daniela Crescenti, Andrea Geviti, Elisa Rossini, Federico Angelo Cazzaniga, Fabio Moda, Elisa R. Zanier, Gisella Guerrera, Luca Battistini, Simone Baiardi, Alessandra Mandelli, Roberto Furlan, Federico Verde, Benedetta Nacmias, Chiara Adriana Elia, Maria Luisa Malosio, Alberto Imarisio, Franca Rosa Guerini, Chiara Fenoglio, Alessio Di Fonzo, Leonardo Biscetti, Margherita Squillario, Silvia Berra, Francesca Miraglia, Paolo Maria Rossini, Camillo Marra, Nicola Vanacore, Alberto Redolfi, Daniela Perani, Patrizia Spadin, Maria Cotelli, Stefano Cappa, Naike Caraglia, Fabrizio Vecchio, Pietro Tiraboschi, Federica Piras, Giovanni B. Frisoni, Cristina Muscio, Raffaele Lodi, Piero Parchi

ePub

03.01.2026

Taewon Kim, Yun Jeong Hong, Mina Kim, Yoonjong Bae, Si Baek Lee, Seong Hoon Kim, Myung Ah Lee, Eunbuel Ko, Jeong Wook Park, Dong Won Yang

The European alternative to PubMed

EUVIMED is currently in beta

Results are beta

Check original sources

Alzheimer s Research & Therapy

2026 · 239 Beiträge

Alzheimer s Research & Therapy

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

The effects of repetitive transcranial magnetic stimulation on executive functions in healthy and at-risk older adults: a systematic review and meta-analysis

Clinicopathological characteristics of Belgian SORL1 mutation carriers

Hippocampal tACS delivered at 40 Hz attenuates VTA dopamine neuron degeneration and neuropathology in a mouse model of Alzheimer’s disease

Multimodal neuromodulation in mild cognitive impairment: emerging evidence and mechanistic hypotheses

Plasma Aβ42/Aβ40 predicts longitudinal amyloid pathology and clinical progression in amyloid-PET negative individuals with subjective cognitive decline

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Predicting clinical dementia rating scores from neuropsychological testing: a machine learning study in a large clinical cohort

A short, automated speech-based assessment detects mild cognitive impairment and dementia: a multicenter study with independent external validation

Prodromal onset presentations, clinical features, and longitudinal cognitive trajectories in dementia with lewy bodies: insights from the CLIMB-DLB cohort

Childhood inductive reasoning, cardiovascular and cardiometabolic morbidity and dementia risk – a population representative cohort study across six decades

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Effect of APOE and LPA genotypes on the risk of dementia after myocardial infarction: a clinic-based cohort study

The efficacy of repetitive transcranial magnetic stimulation for mild-to-moderate Alzheimer’s disease: a systematic review and meta-analysis of global cognitive outcomes

Effects of cerebellar rTMS on cognitive function in Alzheimer’s disease: a randomized controlled fNIRS trial

Exosomal mtDNA profiles enable differential diagnosis of alzheimer’s disease across independent cohorts

Transcriptome signatures associated with cognitively unimpaired individuals with pathologically confirmed Alzheimer disease

Furin deficiency in excitatory neurons leads to cognitive dysfunction and glutamatergic synaptic impairment

Sociodemographic and comorbidity factors mediate ethno-racial differences in plasma Alzheimer’s disease biomarkers

Increases in a pivotal bioactive peptide in specific brain regions reflect the progression of pathology in Alzheimer’s disease

Network connectivity and amyloid-β align with tau in atypical Alzheimer disease subtypes

Optimal amyloid and tau CSF biomarkers for the detection of amyloid and tau PET positivity in a memory clinic population

Live brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research

A CSF NPTX2-based residual metric captures prognostic heterogeneity within a proposed compensatory framework in prodromal Alzheimer’s disease

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

MemTrax as a scalable digital triage tool for mild cognitive impairment screening: primary validation in Alzheimer’s disease and exploratory analysis in Parkinson’s disease

Neuropathological and vascular determinants of cerebral amyloid angiopathy risk: evidence from the NACC cohort

Neuropsychological profiles and behavioural correlates in individuals exposed to repetitive head impacts: findings from the NEwTON study

Resting-state EEG features of cognitive fluctuations across the Lewy body disease spectrum

Personalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol

Resting-state functional dynamics alterations relate to plasma amyloid markers and statistically explain memory impairments in the TgF344-AD model of Alzheimer’s disease

Blood-based immunophenotyping of T cell profiles in patients with neurodegenerative disorders

Three-order interactions in the alpha band of default mode network EEGs based on O-information rate: insights from aging and Alzheimer's disease

Sequential associations of myelin dysfunction with Aβ and Tau pathology in Alzheimer's disease: a dynamic myelin perturbation

Steroid hormones in Alzheimer’s disease: a molecular analysis of blood and cerebrospinal fluid

Real-world safety and implementation challenges of lecanemab therapy for Alzheimer’s disease in South Korea: a single-center experience

Analytical and clinical validation of a novel proximity extension assay-based plasma biomarker panel in a cohort of prevalent neurodegenerative dementias

In vivo evidence for soluble Aβ oligomer-driven neuronal metabolic dysfunction in 5xFAD mice

A probabilistic framework for clinicopathological Alzheimer’s disease using tau-PET

Glycolysis-enhancing α1-adrenergic antagonists have therapeutic potential in Alzheimer’s disease

Clinical outcomes after antipsychotic discontinuation in nursing home residents with dementia: a nationwide cohort study

Chronic pain as a risk factor for Alzheimer’s disease pathology: a longitudinal ADNI study

γ-radiation reduces phosphorylated-tau in rhesus macaque brains: potential implications for Alzheimer’s disease and other tauopathies

The potential of key Alzheimer’s plasma biomarkers to mimic tau PET MUBADA-based disease staging

Lecanemab in practice: AI-derived MRI predictors of benefit and Amyloid Related Imaging Abnormalities (ARIA)

Facial phenotypes in Alzheimer’s disease: from neurobiology to artificial intelligence

Smoking cessation duration and risk of Alzheimer’s disease: a nationwide cohort study in Korea

Structural and molecular determinants of medial temporal lobe network vulnerability in aging and Alzheimer’s disease

Neural changes after computerized cognitive training in coronary heart disease with mild cognitive impairment: secondary analysis of a randomized clinical trial

Real-world effectiveness of monoclonal antibody lecanemab versus acetylcholinesterase inhibitors in Alzheimer’s disease: a target trial emulation

Virtual brain and electroencephalography explain the variance of memory alterations in mild cognitive impairment

Development and validation of a harmonized memory score for multicenter Alzheimer’s disease and related dementia research

Associations of plasma metabolites with protein biomarkers linked to Alzheimer’s disease pathology in the Rotterdam Study

Chronic central-targeted Interleukin-6 overexpression promotes hippocampal and cortical neuropathology in the Tg2576 mouse model of Alzheimer’s disease

Alzheimer’s disease polygenic risk, APOE ε4 dose, and accelerometer-derived circadian rest–activity rhythms in relation to incident dementia and Alzheimer’s disease in UK Biobank: a prospective cohort study

Enhancing Alzheimer’s disease diagnosis in primary care through targeted screening of people at risk of developing dementia – study design and feasibility assessment of the PREDEM primary care study

Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP)

A third-generation, high-affinity biparatopic anti-tau antibody inhibits intracellular tau aggregation seeded by Alzheimer’s brain extracts

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer’s disease

Semantic fluency predicts survival of memory clinic patients

SuperAging is not the inverse of common-variant Alzheimer’s risk: evidence across genetic ancestries

Disruption of temporo-parietal network in Alzheimer’s disease and its association with memory impairment

Thresholds for meaningful change in Mini-Mental State Examination scores in rare dementias

Activity profiles and their associations with transitions between fall and dementia: findings from a multistate time-to-event analysis

Age-dependent diagnostic and correlational architecture of multiplex plasma biomarkers in Alzheimer’s disease: a cross-ethnic, cross-platform validation study

Clinico-biological trajectories stratified by combined tau biomarkers in preclinical Alzheimer’s disease

Outer nuclear layer thinning as an in vivo biomarker for discriminating probable FTLD-tau from probable FTLD-TDP with PET-supported subtyping

Characterizing the MRI signature of hippocampal sclerosis of aging

HDAC7 acts as an astrocytic mediator of Aβ pathology that directly engages IKK to drive astrocyte neurotoxicity and neurodegeneration in Alzheimer’s disease

The prevalence and incidence of young onset dementia in the Netherlands: a prospective study in two catchment areas

Myelin-driven structural network redundancy underlies cognition in cerebral small vessel disease

Associations of plasma biomarkers of Alzheimer’s disease pathology with modifiable risk factors and cognitive and functional outcomes: evidence from cross-sectional prediction and latent path analyses in the Bio-Hermes-001 cohort

Impact of sex differences on microglial function in Alzheimer’s disease

Transcranial pulse stimulation modulates spectral signatures of Alzheimer’s disease in the 3×Tg-AD mouse model

A small molecule modulating heterogeneous amyloid-β isoforms improves cognitive and pathological outcomes in acute and 5XFAD Alzheimer’s disease models

Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts

Estimation of positron emission tomography amyloid load and related biomarkers in Alzheimer’s disease using evoked potential tomography EEG: development and internal validation in a cross-sectional cohort

Shared genetic architecture between Alzheimer’s disease and brain morphology

Methodological approaches to account for assay changes in longitudinal biomarker analysis: insights from Alzheimer’s blood biomarkers in the MEMENTO cohort