Acta Cirúrgica Brasileira

01.01.2026

The effects of dutasteride and tamsulosin, alone or in association, in the kidney morphology: experimental study in rats

ABSTRACT Purpose: To evaluate the renal morphology after isolated and combined administration of dutasteride and tamsulosin in rats. Methods: Forty male rats were divided in groups: control group; D, receiving 0.5 mg/kg/day of dutasteride; T, receiving 0.4 mg/kg/day of tamsulosin …

01.01.2026

Dermalix enhances angiogenesis and collagen remodeling in an ischemic colon anastomosis rat model

ABSTRACT Purpose: To evaluate the effect of Dermalix on anastomotic healing in a rat model of ischemic colon anastomosis. Methods: Forty rats were divided into three groups: negative control (n = 10), control (n = 15), and experimental (n = 15). Only laparotomy was performed in t …

01.01.2026

RETRACTION: Atractylenolide III alleviates sepsis-mediated lung injury via inhibition of FoxO1 and VNN1 protein

01.01.2026

Study on the effect of Portulaca oleracea L. extract on chronic ulcerative colitis in rats induced by allogeneic antigen and acetic acid

ABSTRACT Purpose: To investigate the effect and mechanism of Portulaca oleracea L. (POL) extract on acetic acid and alloantigen-induced chronic ulcerative colitis in rats. Methods: Ulcerative colitis was induced in rats by sensitization with rabbit colon antigen and acetic acid. …

01.01.2026

Bone health up to five years after Roux-en-Y gastric bypass: a cross-sectional study during the COVID-19 pandemic

ABSTRACT Purpose: To evaluate bone health in obese patients undergoing surgery using the Roux-en-Y gastric bypass (RYGB) technique. Methods: In a sample of 22 obese patients undergoing RYGB surgery, evaluation of bone densitometry (BD) and plasma levels of calcium, phosphorus, ma …

01.01.2026

Naringenin improves testicular reproductive function in rats with testicular ischemia-reperfusion injury

ABSTRACT Purpose: The significant change during testicular ischemia-reperfusion is the generation of high levels of reactive oxygen species, which trigger impairment of spermatogenic cells. Naringenin, a plant-derived flavonoid, can alleviate oxidative stress. The current study w …

01.01.2026

Lower content of cerebrospinal fluid chemokines in patients with cancer cachexia

ABSTRACT Purpose: Cancer-associated cachexia (CC) is characterized by involuntary weight loss and poor prognosis. Central nervous system (CNS) inflammation has been linked to CC symptoms. This study evaluated inflammatory mediators in the cerebrospinal fluid (CSF) of patients wit …

01.01.2026

The role of TIPE2 in hemorrhagic shock-induced acute lung injury

ABSTRACT Purpose: Acute lung injury is the most severe complication of hemorrhagic shock and closely correlates with the mortality rate of hemorrhagic shock. TIPE2 is a critical regulator of inflammation and is implicated in the pathogenesis of various inflammatory diseases. Howe …

01.01.2026

Anatomical study of peroneal longus and brevis innervation and its spatial relationship with trigger points

ABSTRACT Purpose: Myofascial pain syndrome (MPS) is a common cause of chronic musculoskeletal pain. Long fibular syndrome is a symptom of lower-limb MPS. Research has associated MPS with motor end plates in the innervation zone. This study aimed to identify the anatomical entry p …

01.01.2026

Time-dependent protective effects of syringic acid following testicular torsion–detorsion: an experimental rat model

ABSTRACT Purpose: To investigate the protective effects of syringic acid (SA) against testicular ischemia–reperfusion (I/R) injury during different reperfusion periods in an experimental rat model. Methods: Forty-eight male Wistar albino rats were randomly assigned to six groups: …

01.01.2026 · 1 Zitationen

Use of polyhexamethylene biguanide on wound healing in dogs

ABSTRACT Purpose: To analyze the effects of polyhexamethylene biguanide (PHMB) on healing of clean surgical wounds in dogs. Methods: Thirty healthy, non-neutered dogs of different breeds underwent elective ovariohysterectomy or orchiectomy, and a 1-cm circular abdominal wound was …

01.01.2026

Performance of complementary therapies in controlling inflammatory signs, symptoms, and complications after lower third molar extraction: a bibliometric analysis of the top 100 most-cited articles

ABSTRACT Purpose: To conduct a bibliometric analysis of the 100 most-cited articles on the use of complementary therapies for controlling inflammatory signs, symptoms, and complications after lower third molar extraction. Methods: An electronic search was performed on the Web of …

01.01.2026

Analgesic strategies in the management of postoperative pain following uterine artery embolization for symptomatic fibroids: a systematic review

ABSTRACT Purpose: To identify and compare anesthetic and analgesic strategies employed during uterine artery embolization for symptomatic leiomyomas, assessing their effectiveness in reducing postoperative pain and opioid use and evaluating complication rates. Methods: A systemat …

01.01.2026

Investigation of the effects of nicotinamide mononucleotide on kidney damage in rats with cecal ligation and perforation sepsis model

ABSTRACT Purpose: To evaluate the protective effects of nicotinamide mononucleotide (NMN), a NAD+ precursor, on kidney tissue in rats with sepsis induced by cecal ligation and puncture model. Methods: In this study, 28 female Sprague Dawley rats were randomly divided into four eq …

01.01.2026

Effectiveness of negative-pressure wound therapy in partial-thickness and full-thickness burns: a systematic review

ABSTRACT Purpose: To evaluate the effectiveness of negative-pressure wound therapy (NPWT) in healing partial- and full-thickness burns in humans. Methods: This systematic review followed the Cochrane Handbook for Systematic Reviews of Interventions and the PRISMA checklist. Resul …

01.01.2026

Educational innovation: mobile applications as complementary tools in the training of plastic surgery residents

ABSTRACT Purpose: To identify and describe mobile applications that can serve as complementary tools in the education of plastic surgery residents. Methods: A structured literature review was conducted across MEDLINE, EMBASE, ERIC, Latin American and Caribbean Health Sciences Lit …

01.01.2026

The use of xenografts with fish skin for the treatment of burns: a systematic review and meta-analysis

ABSTRACT Purpose: To conduct a systematic literature review and meta-analysis to assess the efficacy of fish skin xenografts in burn treatment, comparing reepithelialization time, pain reduction, and the amount of analgesics used. Methods: This review was designed and conducted a …

01.01.2026

Thoracic limb simulator for veterinary vascular access training

ABSTRACT Purpose: To develop and validate a thoracic limb simulator for veterinary vascular access training (TSVT), focusing vein puncture in dogs. Methods: The simulator was designed, three-dimensional printed, and filled with silicone and resin. Five experienced veterinarians, …

01.01.2026

Comparison of the effects of direct and remote ischemic post and preconditioning in the kidney of young rats: histological and laboratory evaluation

ABSTRACT Purpose: To evaluate the effects of direct and remote ischemic preconditioning and postconditioning on kidney ischemia–reperfusion injury in young rats. Methods: This study was divided into two experimental phases: preconditioning and postconditioning. In each phase, 78 …

01.01.2026

A novel combined neutrophil-platelet score for diagnosing complicated appendicitis: a retrospective and prospective cohort study

ABSTRACT Purpose: We investigated the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) and combined them to create an inflammatory marker, the combined neutrophil-platelet score (CNPS), to serve as a diagnostic and predictive tool for complicated ap …

01.01.2026

Damage control resuscitation in resource-diverse settings: a survey-based comparison of trauma care practices worldwide

ABSTRACT Purpose: Trauma is a major global cause of death, with uncontrolled hemorrhage as its leading preventable cause. Damage control resuscitation (DCR) is a cornerstone strategy for hemorrhagic shock, yet implementation varies by resource availability. This study compared DC …

01.01.2026

Evaluation of agmatine efficacy in contrast-induced nephropathy: experimental evidence in rat model

ABSTRACT Purpose: To investigate the biochemical and histopathological efficacy of agmatine as a protective agent in experimental rat contrast-induced nephropathy (CIN) model. Methods: Twenty-eight male Sprague Dawley rats were randomized into four groups: sham (no intervention), …

01.01.2026

Evaluation of self-ligation of the spermatic cord and vas deferens in open orchiectomy of healthy adult crossbreed dogs: clinical assessment, infrared thermography, and inflammatory biomarkers

ABSTRACT Purpose: To evaluate the self-ligation of the spermatic cord and vas deferens in healthy adult dogs undergoing open orchiectomy, through clinical assessment, evaluation of acute inflammation, and surgeon satisfaction. Methods: Twenty adult male crossbreed dogs were inclu …

01.01.2026

Qualitative assessment of anal function in swine model for research in colorectal surgery: development of the swine anal function assessment table

ABSTRACT Purpose: The porcine model is widely used in preclinical studies of anorectal function due to its anatomical and physiological similarity to humans. However, appropriate behavioral and functional evaluation methods of anorectal segment are still lacking. Methods: This st …

01.01.2026

Microsurgical education for medical students: systematic review

ABSTRACT Purpose: To perform a systematic review about microsurgical training for medical students. Methods: A systematic search was conducted in several databases. Screening was performed by two independent reviewers based on predetermined criteria, following PRISMA 2020 guideli …

01.01.2026

Augmented reality in clinical skills simulation: usability and feasibility of smart glasses in a simulated environment

ABSTRACT Purpose: To assess the usability and feasibility of augmented-reality smart glasses during simulated pediatric bladder catheterization with real-time remote specialist guidance. Methods: Thirty-five critical-care graduate healthcare professionals simulated pediatric blad …

01.01.2026

Application of melamine-starch and bixin film (Bixa orellana L.) in wound healing

ABSTRACT Purpose: To evaluate through histological analysis the application of starch-melamine film and bixin (Bixa orellana L.) in wound healing in Wistar rats. Methods: Eighteen male Wistar rats were randomly assigned to three groups (n = 6 per group): Group 1 (control), cutane …

01.01.2026

Astaxanthin alleviates autophagy, inflammation, and oxidative stress in ventilator-associated lung injury rats by inhibiting MAPK/ERK1/2 pathway

ABSTRACT Purpose: Improper use of mechanical ventilation may result in ventilator-induced lung injury (VILI). This work seeks to explore the preventive impact of astaxanthin on VILI. Methods: In this study, we established the VILI rat and drug intervention model, then evaluated l …

01.01.2026

Evaluation of polymeric films and streptokinase for prevention of postoperative intra-abdominal adhesion in rabbits

ABSTRACT Purpose: To evaluate the effectiveness of polymer-based strategies for preventing intra-abdominal adhesions after small colon enterotomy and enterorrhaphy in a rabbit experimental model. Methods: Twenty-four female New Zealand White rabbits were randomly allocated into f …

01.01.2026

Hemostatic net in cervical and facial surgeries: evidence from a systematic review and meta-analysis

ABSTRACT Purpose: Hematoma remains the most frequent complication of cervicofacial surgeries. The hemostatic net (HN), a transcutaneous suture designed to minimize dead space and bleeding, has shown promise, but pooled evidence of its safety and efficacy is limited. Thus, we cond …

01.01.2026

Glaucocalyxin A enhances colonic anastomotic healing after ischemia–reperfusion: experimental findings

ABSTRACT Purpose: Glaucocalyxin A (GLA), a diterpenoid with antioxidative and anti-inflammatory properties, has shown vascular protective effects in preclinical models. This study aimed to evaluate whether GLA improves colonic anastomotic integrity following ischemia–reperfusion …

01.01.2026

Potential molecular targets on which methylene blue acts to promote its effects on cardiac electrophysiology, myocardial injury, and oxidative stress in spontaneously hypertensive rats submitted to cardiac ischemia and reperfusion

ABSTRACT Purpose: Although methylene blue (MB) has long been used to treat vasoplegic syndrome, its pharmacodynamics and cardiovascular effects remain unclear. Therefore, we decided to evaluate the potential molecular targets of MB through molecular docking and its cardioprotecti …

01.01.2026

Thymoquinone and caffeic acid phenethyl ester mitigate experimental ulcerative colitis: a biochemical and histopathological study

ABSTRACT Purpose: To establish an acetic acid-induced acute ulcerative colitis model in rats and to evaluate the clinical, biochemical, and histopathological effects of thymoquinone (TQ) and caffeic acid phenethyl ester (CAPE) in this model. Methods: Forty male Wistar albino rats …

01.01.2026

The beneficial effects of leave extract of Commiphora leptophloeos on intestinal mucositis induced by 5-fluorouracil in mice

ABSTRACT Purpose: This study aimed to evaluate the effect of oral administration of a hydroethanolic extract of Commiphora leptophloeos leaves (CLF) on the progression of 5-fluorouracil (5-FU)-induced intestinal mucositis. Methods: Female Swiss mice were orally administered CLF a …

01.01.2026

Stepwise plication of abdominal mesh technique for open abdomen closure

ABSTRACT Purpose: To present the stepwise plication of abdominal mesh (SPAM) as a standardized dynamic closure technique that combines mesh-mediated fascial traction with negative pressure wound therapy for gradual abdominal wall approximation. Methods: In this technical report, …

01.01.2026 · 3 Zitationen

Cardioprotective effects of the ranolazine in myocardial infarction mediated by stimulation of the endogenous mediators involved in ischemic preconditioning

ABSTRACT Purpose: Hypothesis centered on the idea that ranolazine could induce responses similar to ischemic preconditioning, involving nitric oxide, adenosine, bradykinin, and adenosine triphosphate (ATP)-dependent potassium channels. Methods: Ischemia-reperfusion injury was est …

01.01.2026

Development and preliminary evaluation of a camera-assisted endovascular simulator using a three-dimensional printing

ABSTRACT Purpose: This study described the development and preliminary evaluation of a simulator that combines a three-dimensional-printed vascular model with a camera-assisted system for training basic endovascular skills. Methods: A hollow mannequin torso housed a transparent, …

01.01.2026

Effects of maternal arginine supplementation during lactation on offspring growth and wound healing in an experimental rat model of intrauterine malnutrition

ABSTRACT Purpose: To evaluate the effects of maternal arginine-enriched diet during lactation, following gestational undernutrition, on offspring growth and wound healing. Methods: Pregnant Wistar rats were divided into two groups during gestation: control (C; ad libitum diet) an …

01.01.2026

Anatomical study of the innervation of the tibialis anterior muscle and its relationship with myofascial trigger points

ABSTRACT Purpose: Myofascial trigger points (MTPs) in the tibialis anterior muscle (TAM) are located in the upper third of the muscle and can be activated by various pathologies such as sprains, fractures, and muscle overload. Although the pathophysiology of MTPs is unclear, they …

01.01.2026

Effects of captopril and losartan on early wound healing in hypertensive rats

ABSTRACT Purpose: To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats. Methods: Twenty-seven paraffin-embedded skin wound samples from hypertensive rats were …

01.01.2026

The impact of steroid-impregnated polypropylene mesh on foreign body reaction in an experimental rat study

ABSTRACT Purpose: Foreign body reaction is a tissue response in which excessive reactions may lead to complications such as chronic inflammation, mesh contraction, and impaired tissue integration. The present study aimed to evaluate the effects of steroid-impregnated polypropylen …

01.01.2026

Investigation of the effects of hydroxychloroquine on rats with pulmonary contusion caused by blunt thoracic trauma

ABSTRACT Purpose: To investigate the early and late effects of hydroxychloroquine (HCQ) on inflammation, fibrosis, and apoptosis in an experimental rat model of pulmonary contusion. Methods: Thirty-five male Wistar albino rats were randomly allocated into five groups (n = 7): con …

01.01.2026

Comparative evaluation of a folkloric plant extract in a rat partial nephrectomy model

ABSTRACT Purpose: To evaluate the efficacy and safety of Ankaferd in comparison with Arista and Surgiflo in a rat zero-ischemia partial nephrectomy model. Methods: A total of 28 Wistar albino rats were randomly assigned to four groups: control, Ankaferd, Arista, and Surgiflo. Dur …

01.01.2026

Tissue perfusion and its influencing factors in epigastrial adipocutanous flaps affected by ischemia-reperfusion in rats

ABSTRACT Purpose: In reconstructive surgery, complications of flaps include thrombosis and necrosis, partly originated from ischemia-reperfusion (I/R) injury. Therefore, investigations on the factors that influence tissue perfusion are essential. We wished to investigate microcir …

01.01.2026

Vancomycin-impregnated decellularized bovine pericardium membranes coating silicone implants: in-vivo biocompatibility and antibacterial efficacy in a rat model

ABSTRACT Purpose: To evaluate the inflammatory response, fibrotic encapsulation, tissue integration, and antibacterial effectiveness of silicone implants coated with decellularized bovine pericardium membranes, with or without vancomycin impregnation. Methods: Seventy-two Wistar …

01.01.2026

Normothermic machine perfusion versus static cold storage for liver transplantation: a systematic review and meta-analysis

ABSTRACT Purpose: To compare the effectiveness of normothermic machine perfusion (NMP) with static cold storage (SCS) in preserving transplantable livers, focusing on early postoperative complications. Methods: A PRISMA 2020–compliant search of PubMed, Embase, Scopus, Cochrane Li …

01.01.2026

The impact of enoxaparin on ovarian torsion–detorsion damage in rats

ABSTRACT Purpose: This study aimed to evaluate the protective effects of enoxaparin on ovarian tissue subjected to experimental ischemia/reperfusion (I/R) injury in rats. Methods: Thirty female rats were divided into three groups: control, ischemia/reperfusion (I/R), and ischemia …

01.01.2026

Yellow wave: impact of a structured educational initiative on trauma education development

ABSTRACT Purpose: To evaluate the impact of the Yellow Wave Initiative on trauma surgery education, academic skills, career choices, and educational equity among medical students from three Brazilian medical schools. Methods: This prospective longitudinal study enrolled 58 medica …

01.01.2026

Academic bedside rounding in 10 As: the decalogue technique

ABSTRACT Purpose: To propose the 10 As decalogue technique, a structured framework for surgical bedside rounding. Methods: This narrative review and perspective piece presents a descriptive model for bedside rounding, designed for implementation in university hospitals. Literatur …

01.01.2026 · 1 Zitationen

Predictive factors of surgical difficulty in laparoscopic cholecystectomy in a secondary hospital

ABSTRACT Purpose: To identify preoperative factors predicting surgical difficulty in laparoscopic cholecystectomy at a secondary-level hospital. Methods: A retrospective study included 697 adults undergoing laparoscopic cholecystectomy from January 2021 to June 2024. Demographic, …

01.01.2026

Biocompatibility, biodegradation, and antioxidative potential of alginate-dragon’s blood sap microbeads implanted subcutaneously in mice

ABSTRACT Purpose: To evaluate alginate-dragon’s blood sap microbeads (DBSM) regarding biocompatibility, biodegradation, and antioxidative potential. Methods: Three DBSMs at concentrations of 1, 2, and 5% were developed by the drop spherification, and alginate-1% glycerin microbea …

01.01.2026

Trauma care in Brazil: a comparative study of patient characteristics at public versus private hospitals

ABSTRACT Purpose: Trauma remains a leading cause of hospital admissions worldwide, particularly in low- and middle-income countries. Brazil’s dual healthcare system reflects disparities in resource availability and clinical outcomes. This study compared epidemiological profiles o …

01.01.2026

Induced and spontaneous uterine leiomyomas in animal models: a scoping review

ABSTRACT Purpose: To map the experimental models of induced and spontaneous uterine leiomyomas (UL) in animals, describing induction techniques, evaluation methods, advantages, limitations, and research gaps. Methods: We conducted a systematic review of studies published between …