Wissenschaftliches Journal · EZB
Wiley (Blackwell Publishing)
Inhaltsverzeichnis
11.09.2026
Vicente M. CabreraABSTRACT Objectives From the perspective of uniparental markers, the view of the human prehistoric settlement of America is that it resulted from a single main migration after the Last Glacial Maximum, following a long or short period of genetic isolation in Beringia. Ancient DNA …
11.09.2026
Xiaojian Feng, Zhixian Pan, Guoping LiuABSTRACT Background Inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and gout, shares systemic inflammatory features indexed by C‐reactive protein (CRP) and interleukin‐6 (IL‐6), yet the extent of their common genetic basis remains uncle …
10.09.2026
Bowen Feng, Robert Yang, Gabriella R Wang, Qiu Hu, Chuntao ZhaoABSTRACT Background Leukocyte telomere length (LTL) and epigenetic age acceleration (EAA) are widely studied biomarkers of biological aging, but their potential roles in healthspan remain unclear. We evaluated whether genetically proxied LTL and EAA show evidence of potential eff …
10.09.2026
10.1111/ahg.7005930.08.2026
Enchi Yuan, Ning Zhang, Haoyu He, Tao Zhang, Enze Chen, Qidi Zhang, Dongmei JiABSTRACT Background Variants in the MT‐TI gene, which encodes mitochondrial transfer RNA for isoleucine, have been associated with neuromuscular, cardiac, auditory, renal, and metabolic disorders, but their clinical interpretation remains difficult. Objective To integrate clinica …
23.08.2026
Paulo DarioABSTRACT Background Variant databases ClinVar and gnomAD underpin clinical variant interpretation, but their composition is skewed toward European ancestry. Whether this produces systematic disadvantages for non‐European patients with monogenic diabetes has not been examined at t …
17.08.2026
Sergio V. Flores, Patricia Lillo, Jorge Briceño‐MoyaABSTRACT Background The SOD1 gene encodes superoxide dismutase 1, an antioxidant enzyme in which pathogenic variants cause a subset of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although the clinical and molecular consequences of SOD1 variants are well …
26.07.2026
Sergio Flores Carrasco, Ángel Roco‐Videla, Jorge Briceño‐Moya, Román MontañaABSTRACT Background Early genome‐wide association studies (GWAS) of psychiatric disorders were conducted predominantly in European populations, limiting the understanding of genetic architecture across ancestries. Objectives To summarize current evidence on shared and ancestry‐sp …
24.03.2026 · 1 Zitationen
Woei‐Yuh Saw, Chee Wei Yew, Thuhairah Abdul Rahman, Mohammad Zahirul Hoque, Shuhua Xu, Chiea‐Chuen Khor, Vijay Kumar Subbiah, Yik‐Ying Teo, Boon‐Peng HohABSTRACT Previous studies have highlighted significant genetic structure among Southeast Asian populations, with Northern Borneo natives closely related to Austronesians from Taiwan and the Philippines, and Peninsular Malaysia indigenous populations potentially linked to the indi …
11.08.2026
10.1111/ahg.7005528.07.2026
Yunden Droma, Fengming Yue, Masao Ota, Nobumitsu Kobayashi, Yoshiaki Kitaguchi, Masayuki Hanaoka26.07.2026
Maajid Mohi Ud Din Malik26.07.2026
Seham S. A. Abumarzouq, Alexander Woodman, Abdel Halim DeifallaABSTRACT Background The genetic structure of the Kuwaiti population using Alu insertion variants has not been previously investigated. Objective This study aimed to examine the allele and genotype frequencies of 100 Alu insertion variants in the Kuwaiti population, determine thei …
23.07.2026
Katie Louise Saxby, Svetlana Stoma, Frank Dudbridge, Nilesh J. Samani, Matthew J. Bown, Christopher P. NelsonABSTRACT Aims There is no proven treatment to prevent the growth or rupture of abdominal aortic aneurysm (AAA). As an aneurysm enlarges over time, the risk of fatal aortic rupture increases. Metformin, a drug usually prescribed to treat Type 2 diabetes, has previously been associ …
07.07.2026
Piyash Bhattacharjee, Anika Tahsin, Abdullah Al Saba, Maisha Adiba, Tahirah Yasmin, Akio Ebihara, A. H. M. Nurun NabiABSTRACT Background Interindividual variations in vaccine‐induced immunological responses are well‐observed across different populations. This may underlie the highly polymorphic HLA molecules directly involved in antigen presentation to CD4 + T cells, leading to the generation o …
07.07.2026
Takuma Harasaki, Sachiko Miyamoto, Takahiro Yonekawa, Masaharu Isogai, Mitsuhiro Kato, Mitsuko Nakashima, Hirotomo SaitsuABSTRACT Background Pathogenic variants in L1CAM , located at Xq28, cause a spectrum of neurodevelopmental disorders of varying severity, including congenital hydrocephalus, MASA syndrome, agenesis of the corpus callosum, and intellectual disability. Material and Methods Exome se …
24.06.2026
Ying Zhang, Jing Hu, Lingyan Ren, Fangfang Li, Cheng Zhang, Juan Liu, Guiqin You, Yurong Feng, Shengwen HuangABSTRACT Objective This study aims to screen for genetic variants associated with premature ovarian insufficiency (POI) in a Chinese Miao pedigree. Methods The proband underwent whole exome sequencing (WES), and the extracted data were subjected to bioinformatics analysis using t …
11.06.2026
10.1111/ahg.7004408.06.2026
Sana Kashif Shahid, Syeda Sadia Fatima, Sabah Farhat, Shah Jabeen Khan, Mehir un Nisa IqbalABSTRACT Background Preeclampsia (PE) is a complex pregnancy disorder associated with early placental hypoxia, oxidative stress, and impaired angiogenic signaling. Melatonin and soluble tumor necrosis factor like weak inducer of apoptosis (sTWEAK) contribute to antioxidant and va …
18.05.2026
Wei Shi, Zhenhua Zhu, Minghui Wu, Wenjun Cheng, Haijun XuAbstract Background The bone–brain axis has emerged as a critical framework linking skeletal metabolism to neurodegeneration. Within this axis, bone marrow adipose tissue (BMAT) represents a unique fat depot with distinct endocrine and hematopoietic functions, yet its contributio …
12.05.2026
Mohsine‐Ali El‐Hamri, Zineb Sabky, Nada Benyahya, Oualid Abboussi, Jaber Lyahyai, Abdelaziz SeffianiABSTRACT Background and Aims Inborn errors of immunity (IEI) refer to a heterogeneous group of monogenic disorders caused by germline variants that disrupt immune function. Among these conditions, immunodeficiency 92 (IMD92), an extremely rare autosomal recessive disorder due to …
24.04.2026
Yongchao Yu, Yuan Zhu, Qian Tian, Lijuan Shao, Jiao Zeng, Dandan Xu, Xiangang MoABSTRACT Purpose Atherosclerosis (AS) is a leading cause of cardiovascular disease, and current treatments often fail to induce plaque regression. This study aims to identify novel, genetically supported therapeutic targets for AS to enable more effective drug development. Method …
14.04.2026
Emmanuel Owusu Ansah, Emmanuel Boateng Agyenim, Andrews Danquah, Stephen Kumi Addo, Daniel Sakyi Agyirifo, Kwadwo Fosu, Foster KyeiABSTRACT Background Breast cancer (BC) is a major global health concern. Although observational studies have reported an association between hypertension and BC risk, the causal nature of this relationship remains unclear. Methods We performed a univariate two‐sample Mendelian ra …
01.04.2026
10.1111/ahg.7003708.02.2026 · 2 Zitationen
Yunden Droma, Fengming Yue, Masao Ota, Nobumitsu Kobayashi, Yoshiaki Kitaguchi, Masayuki HanaokaABSTRACT Background and Aims Sherpa highlanders exhibit remarkable tolerance to hypoxia, most likely due to genetic adaptations shaped by natural selection at high altitude. This study examined the roles of endothelial PAS domain protein 1 ( EPAS1 ) and egl‐9 family hypoxia‐induc …
02.02.2026
Rachel R. Dickerson, Riku Takei, Murray Cadzow, Theodore G. Schurr, Phillip L. Wilcox, Nicola Dalbeth, Lisa K. Stamp, Rinki Murphy, Janak R. de Zoysa, Stephane E. Castel, Anne‐Katrin Emde, Kaja A. Wasik, Tony R. Merriman, Anna L. GoslingABSTRACT Background Mitochondrial proteins are encoded by both mitochondrial‐ and nuclear‐encoded genes. Because mitochondrial DNA (mtDNA) is maternally inherited, admixed individuals may have different ancestral sources for their nuclear and mitochondrial genomes. The potential …
15.01.2026
Xiawei Li, Min Wang, Xiang Zhang, Bilige, Zhiye Du, Yongqi Yang, Baotong ZhangABSTRACT Background Hepatocellular carcinoma (HCC) is a highly aggressive cancer with significant intratumoral heterogeneity, likely contributed by the differentiation of cancer stem‐like cells (CSCs) into multiple cancer cell lineages, resulting in therapeutic resistance and inc …
