10.3390/polym8030084

Vollständiger Abstract

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<h4>Background</h4>Conventional cardiovascular risk scores do not directly characterize immune checkpoint-expression phenotypes in people with HIV. We examined patient-level alignment between SCORE2 and PD-1/PD-L1 checkpoint expression in a secondary analysis of a previously characterized parent cohort.<h4>Methods</h4>Data from 100 PWH followed at a single HIV center were analyzed. SCORE2, lipid parameters, systolic blood pressure, CD4+/CD8+ ratio, and flow-cytometric PD-1/PD-L1 expression on T-cell, B-cell, and NK-cell subsets were assessed at baseline and after 12 months. Composite immune-exhaustion indices were derived from standardized checkpoint-marker values. Discordance profiles were defined using quartile thresholds for endpoint SCORE2 and immune exhaustion.<h4>Results</h4>Smokers had higher endpoint SCORE2 than nonsmokers (median 3.5% vs. 1.0%; <i>p</i> = 0.001), but smoking was not associated with higher composite or individual checkpoint-defined exhaustion. Endpoint SCORE2 correlated with classical cardiovascular variables but not with the composite exhaustion index (ρ = 0.075; <i>p</i> = 0.468) or individual PD-1/PD-L1 markers. Discordant cardiovascular-immune profiles were observed in 10 of 96 evaluable participants (10.4%).<h4>Conclusions</h4>SCORE2 and PD-1/PD-L1 checkpoint-expression profiles showed limited contemporaneous alignment in this cohort. The identified discordant profiles are exploratory and require external validation.

Abstract: PubMed · Datensatz