10.3389/fpsyg.2012.00132

Vollständiger Abstract

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<h4>Background/objectives</h4>To investigate the clinical efficacy, fungal clearance rate, and impact on quality of life of fractional laser combined with amorolfine hydrochloride cream in the treatment of onychomycosis.<h4>Methods</h4>This study retrospectively analyzed 90 patients diagnosed with onychomycosis who were admitted to our hospital between November 2023 and November 2024. According to the treatment strategies received during routine clinical practice, patients were assigned to either the conventional group or the study group, with 45 cases in each group. The conventional group received amorolfine hydrochloride cream alone combined with routine nursing care, whereas the study group additionally received fractional laser therapy and targeted comprehensive nursing intervention on this basis. Comparative analyses were conducted between the two groups with respect to the fungal clearance rate, overall clinical intervention efficacy, quality-of-life scores before and after the intervention, incidence of adverse events, and nursing satisfaction.<h4>Results</h4>After the intervention, the overall clinical effective rate and fungal clearance rate in the study group (95.56 ± 3.5, 95.56 ± 3.2%) were both significantly higher than those in the conventional group (82.22 ± 4.2, 77.78 ± 4.9%) (<i>p</i> < 0.05). The degree of improvement in quality of life among patients in the study group was significantly better than that in the conventional group (<i>p</i> < 0.05). In addition, the incidence of adverse events in the study group was significantly lower than that in the conventional group (<i>p</i> < 0.05), and the overall patient satisfaction with nursing care was significantly higher than that in the conventional group (<i>p</i> < 0.05).<h4>Conclusion</h4>Compared with amorolfine hydrochloride cream alone, fractional laser combined with amorolfine hydrochloride cream is safer and more effective in the treatment of onychomycosis, improves nursing outcomes, increases the fungal clearance rate, enhances quality of life, and reduces adverse events.

Abstract: PubMed · Datensatz